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Tissue-based diagno...
Tissue-based diagnosis of systemic amyloidosis : Experience of the informal diagnostic center at Uppsala University Hospital
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- Vesterlund Damjanovic, Justina (författare)
- Uppsala Univ Hosp, Clin Pathol, Uppsala, Sweden.;Uppsala Univ, Dept Genet Immunol & Pathol, Uppsala, Sweden.
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- Ihse, Elisabet, 1977- (författare)
- Uppsala universitet,Geriatrik,Uppsala Univ Hosp, Clin Pathol, Uppsala, Sweden.;Uppsala Univ, Dept Genet Immunol & Pathol, Uppsala, Sweden.
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- Thelander, Ulrika (författare)
- Uppsala Univ Hosp, Clin Pathol, Uppsala, Sweden.;Uppsala Univ, Dept Genet Immunol & Pathol, Uppsala, Sweden.
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- Zancanaro, Alice (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Uppsala Univ, Dept Genet Immunol & Pathol, Uppsala, Sweden.
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- Westermark, Gunilla (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Med Cell Biol, Uppsala, Sweden.
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- Westermark, Per (författare)
- Uppsala universitet,Neuroonkologi och neurodegeneration,Uppsala Univ Hosp, Clin Pathol, Uppsala, Sweden.;Uppsala Univ, Dept Genet Immunol & Pathol, Uppsala, Sweden.
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Uppsala Univ Hosp, Clin Pathol, Uppsala, Sweden;Uppsala Univ, Dept Genet Immunol & Pathol, Uppsala, Sweden. Geriatrik (creator_code:org_t)
- 2022-09-27
- 2022
- Engelska.
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Ingår i: Upsala Journal of Medical Sciences. - : UPSALA MED SOC. - 0300-9734 .- 2000-1967. ; 127:1
- Relaterad länk:
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https://doi.org/10.4...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- Diagnosis of systemic amyloidosis is a clinical challenge and usually relies on a tissue biopsy. We have developed diagnostic methods based on the presence of amyloid deposits in abdominal subcutaneous fat tissue. This tissue is also used to determine the biochemical type of amyloidosis, performed by western blot and immunohistochemical analyses with the aid of in-house developed rabbit antisera and mouse monoclonal antibodies. Mass spectrometric methods are under development for selected cases. The diagnostic outcome for 2018-2020 was studied. During this period, we obtained 1,562 biopsies, of which 1,397 were unfixed subcutaneous fat tissue with varying degrees of suspicion of systemic amyloidosis. Of these, 440 contained amyloid deposits. The biochemical nature of the amyloid was determined by western blot analysis in 319 specimens and by immunohistochemistry in further 51 cases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Amyloidosis
- systemic
- monoclonal antibodies
- subcutaneous fat tissue
- biopsy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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