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Posterior reversibl...
Posterior reversible encephalopathy syndrome in children with acute lymphoblastic leukemia : Clinical characteristics, risk factors, course, and outcome of disease
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- Anastasopoulou, Stavroula (author)
- Karolinska Institutet
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- Eriksson, Mats A. (author)
- Karolinska Institutet
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- Heyman, Mats (author)
- Karolinska Institutet
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- Wang, Chen (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden
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- Niinimäki, Riitta (author)
- Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland;Univ Oulu, PEDEGO Res Unit, Oulu, Finland
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- Mikkel, Sirje (author)
- Univ Tartu, Dept Hematol & Oncol, Tartu, Estonia
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- Vaitkeviciene, Goda E. (author)
- Vilnius Univ Hosp Santaros Klin, Childrens Hosp, Vilnius, Lithuania;Vilnius Univ, Vilnius, Lithuania
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- Johannsdottir, Inga Maria (author)
- Oslo Univ Hosp, Dept Pediat Hematol Oncol, Oslo, Norway
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- Myrberg, Ida Hed (author)
- Karolinska Institutet
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- Jonsson, Olafur Gisli (author)
- Univ Iceland, Dept Pediat, Reykjavik, Iceland
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- Als-Nielsen, Bodil (author)
- Rigshosp, Univ Hosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark
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- Schmiegelow, Kjeld (author)
- Rigshosp, Univ Hosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark
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- Banerjee, Joanna (author)
- Univ Helsinki, Childrens Hosp, Dept Pediat Hematol Oncol & Stem Cell Transplanta, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland
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- Harila-Saari, Arja H. (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Ranta, Susanna (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-12-27
- 2019
- English.
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In: Pediatric Blood & Cancer. - : WILEY. - 1545-5009 .- 1545-5017. ; 66:5
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Posterior reversible encephalopathy syndrome (PRES) is a distinct entity with incompletely known predisposing factors. The aim of this study is to describe the incidence, risk factors, clinical course, and outcome of PRES in childhood acute lymphoblastic leukemia (ALL).Procedure: Patients aged 1.0 to 17.9 years diagnosed with ALL from July 2008 to December 2015 and treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol were included. Patients with PRES were identified in the prospective NOPHO leukemia toxicity registry, and clinical data were collected from the medical records.Results: The study group included 1378 patients, of whom 52 met the criteria for PRES. The cumulative incidence of PRES at one month was 1.7% (95% CI, 1.1-2.5) and at one year 3.7% (95% CI, 2.9-4.9). Older age (hazard ratios [HR] for each one-year increase in age 1.1; 95% CI, 1.0-1.2, P = 0.001) and T-cell immunophenotype (HR, 2.9; 95% CI, 1.6-5.3, P = 0.0005) were associated with PRES. Central nervous system (CNS) involvement (odds ratios [OR] = 2.8; 95% CI, 1.2-6.5, P = 0.015) was associated with early PRES and high-risk block treatment (HR = 2.63; 95% CI, 1.1-6.4, P = 0.033) with late PRES. At follow-up of the PRES patients, seven patients had epilepsy and seven had neurocognitive difficulties.Conclusion: PRES is a neurotoxicity in the treatment of childhood ALL with both acute and long-term morbidity. Older age, T-cell leukemia, CNS involvement and high-risk block treatment are risk factors for PRES.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- ALL
- neuroimaging
- PRES
- seizures
Publication and Content Type
- ref (subject category)
- art (subject category)
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Anastasopoulou, ...
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Eriksson, Mats A ...
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Heyman, Mats
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Wang, Chen
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Niinimäki, Riitt ...
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Mikkel, Sirje
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Vaitkeviciene, G ...
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Johannsdottir, I ...
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Myrberg, Ida Hed
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Jonsson, Olafur ...
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Als-Nielsen, Bod ...
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Schmiegelow, Kje ...
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Banerjee, Joanna
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Harila-Saari, Ar ...
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Ranta, Susanna
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Pediatric Blood ...
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Uppsala University
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Karolinska Institutet