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Exploring the use o...
Exploring the use of amine modified mesoporous magnesium carbonate for the delivery of salicylic acid in topical formulations: : in vitro cytotoxicity and drug release studies
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- Vall, Maria (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Ferraz, Natalia, 1976- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Cheung, Ocean (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Strömme, Maria, 1970- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Zardán Gómez de la Torre, Teresa (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
- 2019-05-11
- 2019
- Engelska.
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Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 24:9
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Salicylic acid (SA) has for a long time been used to treat various skin disorders due to its anti-inflammatory, bacteriostatic, and antifungal properties. In the present work, mesoporous magnesium carbonate (MMC), a promising drug carrier, was modified with 3-aminopropyl-triethoxysilane to enable loading of SA. The amine modified MMC (aMMC) was successfully loaded with 8 wt.% of SA via a solvent evaporation method. SA was later completely released from the carrier in less than 15 min. Furthermore, the cytotoxicity of the functionalized material was evaluated. aMMC was found to be non-toxic for human dermal fibroblast cells with particle concentration of up to 1000 µg/mL when exposed for 48 h. The presented results form the basis of future development of aMMC as a potential carrier for SA in dermatological applications.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Nyckelord
- mesoporous; magnesium carbonate; amine functionalization; cytotoxicity; salicylic acid; drug release
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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