Molecular clocks reduce plasmid loss rates: The R1 case

• Plasmids control their replication so that the replication frequency per plasmid copy responds to the number of plasmid copies per cell. High sensitivity amplification in replication response to copy number deviations generally reduces variation in copy n

Keyword

R1; plasmid; regulation; stochastic; kinetics; COPY-NUMBER CONTROL; ESCHERICHIA-COLI; ANTISENSE RNA; BACTERIAL PLASMIDS; MATHEMATICAL-MODEL; REPLICATION; STABILITY; GROWTH; INSTABILITY; INHIBITION

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art (subject category)