Sökning: onr:"swepub:oai:DiVA.org:uu-381764" >
PET/MRI of glucose ...
-
Lundström, ElinUppsala universitet,Radiologi
(författare)
PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
2021-07-22
-
Springer Nature,2021
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-381764
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-381764URI
-
https://doi.org/10.1038/s41598-021-87768-wDOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Title in dissertation list of papers: PET/MRI of glucose uptake, lipid content and perfusion in human brown adipose tissue.
-
This study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MRglu) and changes in lipid content, perfusion and arterial blood volume (V-A) within cervical-supraclavicular fat (sBAT). Twelve volunteers underwent PET/MRI at baseline, during cold exposure and reheating. For each temperature condition, perfusion and V-A were quantified with dynamic [O-15]water-PET, and FF, with water-fat MRI. MRglu was assessed with dynamic [F-18]fluorodeoxyglucose-PET during cold exposure. sBAT was defined using anatomical criteria, and its subregion sBAT(HI), by MRglu>11 mu mol/100 cm(3)/min. For all temperature conditions, sBAT-FF correlated negatively with sBAT-MRglu (rho <=- 0.87). After 3 h of cold, sBAT-FF decreased (- 2.13 percentage points) but tended to normalize during reheating although sBAT(HI)-FF remained low. sBAT-perfusion and sBAT-V-A increased during cold exposure (perfusion:+5.2 ml/100 cm(3)/min, V-A:+4.0 ml/100 cm(3)). sBAT-perfusion remained elevated and sBAT-V-A normalized during reheating. Regardless of temperature condition during the Cooling-reheating protocol, sBAT-FF could predict the cold-induced sBAT-MRglu. The FF decreases observed after reheating were mainly due to lipid consumption, but could potentially be underestimated due to intracellular lipid replenishment. The influence of perfusion and V-A, on the changes in FF observed during cold exposure, could not be ruled out.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Andersson, JonathanUppsala universitet,Radiologi(Swepub:uu)jonan358
(författare)
-
Engström, MathiasGE Healthcare
(författare)
-
Lubberink, MarkUppsala universitet,Radiologi,Uppsala Univ Hosp, Med Phys, Uppsala, Sweden.(Swepub:uu)marklubb
(författare)
-
Strand, Robin,1978-Uppsala universitet,Avdelningen för visuell information och interaktion,Radiologi(Swepub:uu)rostr275
(författare)
-
Ahlström, Håkan,1953-Uppsala universitet,Radiologi,BioVenture Hub, Antaros Med, Mölndal, Sweden.(Swepub:uu)hakanahl
(författare)
-
Kullberg, Joel,1979-Uppsala universitet,Radiologi,BioVenture Hub, Antaros Med, Mölndal, Sweden.(Swepub:uu)jokul377
(författare)
-
Uppsala universitetRadiologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Scientific Reports: Springer Nature112045-2322
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lundström, Elin
-
Andersson, Jonat ...
-
Engström, Mathia ...
-
Lubberink, Mark
-
Strand, Robin, 1 ...
-
Ahlström, Håkan, ...
-
visa fler...
-
Kullberg, Joel, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Radiologi och bi ...
- Artiklar i publikationen
-
Scientific Repor ...
- Av lärosätet
-
Uppsala universitet