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Constitutive seroto...
Constitutive serotonin transporter reduction resembles maternal separation with regard to stress-related gene expression
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- Comasco, Erika, 1982- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Comasco: Neuropsykofarmakologi
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- Schijven, Dick (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- de Maeyer, Hanne (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Science for Life Laboratory, SciLifeLab
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- Vrettou, Maria (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Comasco: Neuropsykofarmakologi
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- Nylander, Ingrid, 1957- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Sundström-Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Reproduktiv hälsa
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- Olivier, Jocelien D. A., 1978- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Department Neurobiology, Unit Behavioural Neuroscience, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen 9712 CP, The Netherlands
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(creator_code:org_t)
- 2019-01-07
- 2019
- Engelska.
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Ingår i: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 10:7, s. 3132-3142
- Relaterad länk:
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https://pure.mpg.de/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Interactive effects between allelic variants of the serotonin transporter (5-HTT) promoter-linked polymorphic region (5-HTTLPR) and stressors on depression symptoms have been documented, as well as questioned, by meta-analyses. Translational models of constitutive 5-htt reduction and experimentally controlled stressors often led to inconsistent behavioral and molecular findings and often did not include females. The present study sought to investigate the effect of 5-htt genotype, maternal separation, and sex on the expression of stress-related candidate genes in the rat hippocampus and frontal cortex. The mRNA expression levels of Avp, Pomc, Crh, Crhbp, Crhr1, Bdnf, Ntrk2, Maoa, Maob, and Comt were assessed in the hippocampus and frontal cortex of 5-htt± and 5-htt+/+ male and female adult rats exposed, or not, to daily maternal separation for 180 min during the first 2 postnatal weeks. Gene- and brain region-dependent, but sex-independent, interactions between 5-htt genotype and maternal separation were found. Gene expression levels were higher in 5-htt+/+ rats not exposed to maternal separation compared with the other experimental groups. Maternal separation and 5-htt+/− genotype did not yield additive effects on gene expression. Correlative relationships, mainly positive, were observed within, but not across, brain regions in all groups except in non-maternally separated 5-htt+/+ rats. Gene expression patterns in the hippocampus and frontal cortex of rats exposed to maternal separation resembled the ones observed in rats with reduced 5-htt expression regardless of sex. These results suggest that floor effects of 5-htt reduction and maternal separation might explain inconsistent findings in humans and rodents.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Frontal cortex
- hippocampus
- maternal separation
- serotonin transporter
- gene expression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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