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Sökning: WFRF:(Flor Herta) > (2019) > Bleich Stefan > Allele-Specific Met...

  • Tay, NicoleKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)

Allele-Specific Methylation of SPDEF : A Novel Moderator of Psychosocial Stress and Substance Abuse

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • AMER PSYCHIATRIC PUBLISHING, INC,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-381924
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-381924URI
  • https://doi.org/10.1176/appi.ajp.2018.17121360DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140616158URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: Psychosocial stress is a key risk factor for substance abuse among adolescents. Recently, epigenetic processes such as DNA methylation have emerged as potential mechanisms that could mediate this relationship. The authors conducted a genome-wide methylation analysis to investigate whether differentially methylated regions are associated with psychosocial stress in an adolescent population.Methods: A methylome-wide analysis of differentially methylated regions was used to examine a sample of 1,287 14-year-old adolescents (50.7% of them female) from the European IMAGEN study. The Illumina 450k array was used to assess DNA methylation, pyrosequencing was used for technical replication, and linear regression analyses were used to identify associations with psychosocial stress and substance use (alcohol and tobacco). Findings were replicated by pyrosequencing a test sample of 413 participants from the IMAGEN study.Results: Hypermethylation in the sterile alpha motif/pointed domain containing the ETS transcription factor (SPDEF) gene locus was associated with a greater number of stressful life events in an allele-dependent way. Among individuals with the minor G-allele, SPDEF methylation moderated the association between psychosocial stress and substance abuse. SPDEF methylation interacted with lifetime stress in gray matter volume in the right cuneus, which in turn was associated with the frequency of alcohol and tobacco use. SPDEF was involved in the regulation of trans-genes linked to substance use.Conclusions: Taken together, the study findings describe a novel epigenetic mechanism that helps explain how psychosocial stress exposure influences adolescent substance abuse.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Macare, ChristineKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Liu, YunFudan Univ, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Sch Basic Med Sci, Shanghai, Peoples R China (författare)
  • Ruggeri, BarbaraKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Jia, TianyeKarolinska Institutet (författare)
  • Chu, CongyingKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Biondo, FrancescaKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Ing, AlexKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Luo, QiangFudan Univ, Sch Life Sci, Shanghai, Peoples R China;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China (författare)
  • Sarkisyan, DaniilUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)dansa302 (författare)
  • Banaschewski, TobiasHeidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany (författare)
  • Barker, Gareth J.Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Bokde, Arun L. W.Trinity Coll Dublin, Discipline Psychiat, Sch Med, Dublin, Ireland;Trinity Coll Dublin, Trinity Coll, Inst Neurosci, Dublin, Ireland (författare)
  • Bromberg, UliUniv Med Ctr Hamburg Eppendorf, Hamburg, Germany (författare)
  • Büchel, ChristianUniv Med Ctr Hamburg Eppendorf, Hamburg, Germany (författare)
  • Quinlan, Erin BurkeKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Desrivieres, SylvaneKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Flor, HertaHeidelberg Univ, Dept Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Univ Mannheim, Dept Psychol, Sch Social Sci, Mannheim, Germany (författare)
  • Frouin, VincentUniv Paris Saclay, NeuroSpin, Gif Sur Yvette, France (författare)
  • Garavan, HughUniv Vermont, Dept Psychiat, Burlington, VT USA;Univ Vermont, Dept Psychol, Burlington, VT 05405 USA (författare)
  • Gowland, PennyUniv Nottingham, Sir Peter Mansfield Imaging Ctr Sch Phys, Nottingham, England (författare)
  • Heinz, AndreasUniv Med Berlin, Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Berlin, Germany (författare)
  • Ittermann, BerndPhys Tech Bundesanstalt, Berlin, Germany (författare)
  • Martinot, Jean-LucUniv Paris 05, Univ Paris Sud Paris Saclay, Unit 1000 Neuroimaging & Psychiat, DIGITEO Labs,INSERM, Gif Sur Yvette, France;Cochin Hosp, Maison Solenn, Paris, France (författare)
  • Artiges, EricUniv Paris Saclay, Univ Paris Sud, DIGITEO Labs, INSERM, Gif Sur Yvette, France;Orsay Hosp, Dept Psychiat, Orsay, France (författare)
  • Nees, FraukeTrinity Coll Dublin, Discipline Psychiat, Sch Med, Dublin, Ireland;Trinity Coll Dublin, Trinity Coll, Inst Neurosci, Dublin, Ireland;Heidelberg Univ, Dept Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Nees German Res Fdn, Bonn, Germany (författare)
  • Orfanos, Dimitri PapadopoulosUniv Paris Saclay, NeuroSpin, Gif Sur Yvette, France (författare)
  • Paus, TomasUniv Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil, Hosp & Dept Psychol, Toronto, ON, Canada;Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil, Dept Psychiat, Toronto, ON, Canada (författare)
  • Poustka, LuiseUniv Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Gottingen, Germany;Med Univ Vienna, Clin Child & Adolescent Psychiat, Vienna, Austria (författare)
  • Hohmann, SarahHeidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany (författare)
  • Fröhner, Juliane H.Tech Univ Dresden, Dept Psychiat, Dresden, Germany;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany (författare)
  • Smolka, Michael N.Tech Univ Dresden, Dept Psychiat, Dresden, Germany;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany (författare)
  • Walter, HenrikUniv Med Berlin, Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Berlin, Germany (författare)
  • Whelan, RobertTrinity Coll Dublin, Sch Psychol, Dublin, Ireland;Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland (författare)
  • Frieling, HelgeHannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany (författare)
  • Bleich, StefanHannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany (författare)
  • Barker, Edward D.Kings Coll London, Ctr Neuroimaging Sci, Inst Psychiat Psychol & Neurosci, London, England (författare)
  • Syvänen, Ann-Christine,1950-Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)anncsyva (författare)
  • Rüegg, JoelleKarolinska Institutet (författare)
  • Ekström, Tomas J.Karolinska Inst, Dept Clin Neurosci, Ctr Mol Med, Stockholm, Sweden (författare)
  • Bakalkin, GeorgyUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)gueba200 (författare)
  • Schumann, GunterKings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England (författare)
  • Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, EnglandFudan Univ, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Sch Basic Med Sci, Shanghai, Peoples R China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Psychiatry: AMER PSYCHIATRIC PUBLISHING, INC176:2, s. 146-1550002-953X1535-7228

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