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Allele-Specific Met...
Allele-Specific Methylation of SPDEF : A Novel Moderator of Psychosocial Stress and Substance Abuse
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- Tay, Nicole (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Macare, Christine (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Liu, Yun (författare)
- Fudan Univ, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Sch Basic Med Sci, Shanghai, Peoples R China
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visa fler...
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- Ruggeri, Barbara (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Jia, Tianye (författare)
- Karolinska Institutet
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- Chu, Congying (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Biondo, Francesca (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Ing, Alex (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Luo, Qiang (författare)
- Fudan Univ, Sch Life Sci, Shanghai, Peoples R China;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China
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- Sarkisyan, Daniil (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Banaschewski, Tobias (författare)
- Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany
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- Barker, Gareth J. (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Bokde, Arun L. W. (författare)
- Trinity Coll Dublin, Discipline Psychiat, Sch Med, Dublin, Ireland;Trinity Coll Dublin, Trinity Coll, Inst Neurosci, Dublin, Ireland
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- Bromberg, Uli (författare)
- Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
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- Büchel, Christian (författare)
- Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
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- Quinlan, Erin Burke (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Desrivieres, Sylvane (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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- Flor, Herta (författare)
- Heidelberg Univ, Dept Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Univ Mannheim, Dept Psychol, Sch Social Sci, Mannheim, Germany
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- Frouin, Vincent (författare)
- Univ Paris Saclay, NeuroSpin, Gif Sur Yvette, France
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- Garavan, Hugh (författare)
- Univ Vermont, Dept Psychiat, Burlington, VT USA;Univ Vermont, Dept Psychol, Burlington, VT 05405 USA
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- Gowland, Penny (författare)
- Univ Nottingham, Sir Peter Mansfield Imaging Ctr Sch Phys, Nottingham, England
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- Heinz, Andreas (författare)
- Univ Med Berlin, Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Berlin, Germany
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- Ittermann, Bernd (författare)
- Phys Tech Bundesanstalt, Berlin, Germany
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- Martinot, Jean-Luc (författare)
- Univ Paris 05, Univ Paris Sud Paris Saclay, Unit 1000 Neuroimaging & Psychiat, DIGITEO Labs,INSERM, Gif Sur Yvette, France;Cochin Hosp, Maison Solenn, Paris, France
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- Artiges, Eric (författare)
- Univ Paris Saclay, Univ Paris Sud, DIGITEO Labs, INSERM, Gif Sur Yvette, France;Orsay Hosp, Dept Psychiat, Orsay, France
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- Nees, Frauke (författare)
- Trinity Coll Dublin, Discipline Psychiat, Sch Med, Dublin, Ireland;Trinity Coll Dublin, Trinity Coll, Inst Neurosci, Dublin, Ireland;Heidelberg Univ, Dept Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Nees German Res Fdn, Bonn, Germany
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- Orfanos, Dimitri Papadopoulos (författare)
- Univ Paris Saclay, NeuroSpin, Gif Sur Yvette, France
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- Paus, Tomas (författare)
- Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil, Hosp & Dept Psychol, Toronto, ON, Canada;Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil, Dept Psychiat, Toronto, ON, Canada
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- Poustka, Luise (författare)
- Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Gottingen, Germany;Med Univ Vienna, Clin Child & Adolescent Psychiat, Vienna, Austria
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- Hohmann, Sarah (författare)
- Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany
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- Fröhner, Juliane H. (författare)
- Tech Univ Dresden, Dept Psychiat, Dresden, Germany;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany
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- Smolka, Michael N. (författare)
- Tech Univ Dresden, Dept Psychiat, Dresden, Germany;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany
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- Walter, Henrik (författare)
- Univ Med Berlin, Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Berlin, Germany
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- Whelan, Robert (författare)
- Trinity Coll Dublin, Sch Psychol, Dublin, Ireland;Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland
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- Frieling, Helge (författare)
- Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany
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- Bleich, Stefan (författare)
- Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany
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- Barker, Edward D. (författare)
- Kings Coll London, Ctr Neuroimaging Sci, Inst Psychiat Psychol & Neurosci, London, England
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- Syvänen, Ann-Christine, 1950- (författare)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Rüegg, Joelle (författare)
- Karolinska Institutet
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- Ekström, Tomas J. (författare)
- Karolinska Inst, Dept Clin Neurosci, Ctr Mol Med, Stockholm, Sweden
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- Bakalkin, Georgy (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Schumann, Gunter (författare)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med, Inst Psychiat, London, England;Kings Coll London, SGDP Ctr, Inst Psychiat, London, England
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(creator_code:org_t)
- AMER PSYCHIATRIC PUBLISHING, INC, 2019
- 2019
- Engelska.
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Ingår i: American Journal of Psychiatry. - : AMER PSYCHIATRIC PUBLISHING, INC. - 0002-953X .- 1535-7228. ; 176:2, s. 146-155
- Relaterad länk:
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https://ajp.psychiat...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: Psychosocial stress is a key risk factor for substance abuse among adolescents. Recently, epigenetic processes such as DNA methylation have emerged as potential mechanisms that could mediate this relationship. The authors conducted a genome-wide methylation analysis to investigate whether differentially methylated regions are associated with psychosocial stress in an adolescent population.Methods: A methylome-wide analysis of differentially methylated regions was used to examine a sample of 1,287 14-year-old adolescents (50.7% of them female) from the European IMAGEN study. The Illumina 450k array was used to assess DNA methylation, pyrosequencing was used for technical replication, and linear regression analyses were used to identify associations with psychosocial stress and substance use (alcohol and tobacco). Findings were replicated by pyrosequencing a test sample of 413 participants from the IMAGEN study.Results: Hypermethylation in the sterile alpha motif/pointed domain containing the ETS transcription factor (SPDEF) gene locus was associated with a greater number of stressful life events in an allele-dependent way. Among individuals with the minor G-allele, SPDEF methylation moderated the association between psychosocial stress and substance abuse. SPDEF methylation interacted with lifetime stress in gray matter volume in the right cuneus, which in turn was associated with the frequency of alcohol and tobacco use. SPDEF was involved in the regulation of trans-genes linked to substance use.Conclusions: Taken together, the study findings describe a novel epigenetic mechanism that helps explain how psychosocial stress exposure influences adolescent substance abuse.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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Tay, Nicole
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Macare, Christin ...
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Liu, Yun
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Ruggeri, Barbara
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Jia, Tianye
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Chu, Congying
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visa fler...
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Biondo, Francesc ...
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Ing, Alex
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Luo, Qiang
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Sarkisyan, Danii ...
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Banaschewski, To ...
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Barker, Gareth J ...
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Bokde, Arun L. W ...
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Bromberg, Uli
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Büchel, Christia ...
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Quinlan, Erin Bu ...
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Desrivieres, Syl ...
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Flor, Herta
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Frouin, Vincent
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Garavan, Hugh
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Gowland, Penny
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Heinz, Andreas
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Ittermann, Bernd
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Martinot, Jean-L ...
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Artiges, Eric
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Nees, Frauke
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Orfanos, Dimitri ...
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Paus, Tomas
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Poustka, Luise
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Hohmann, Sarah
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Fröhner, Juliane ...
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Smolka, Michael ...
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Walter, Henrik
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Whelan, Robert
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Frieling, Helge
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Bleich, Stefan
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Barker, Edward D ...
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Syvänen, Ann-Chr ...
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Rüegg, Joelle
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Ekström, Tomas J ...
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Bakalkin, Georgy
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Schumann, Gunter
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American Journal ...
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Uppsala universitet
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Karolinska Institutet