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  • Miao, LingchaoUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (author)

The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-kappa B and MAPK activation

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • ELSEVIER SCI LTD,2019
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-382803
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382803URI
  • https://doi.org/10.1016/j.foodchem.2019.04.005DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Portulaca oleracea L. (Purslane) has great potential as food and traditional drugs in several countries. The purpose of this study was to evaluate the anti-inflammatory effects of purslane extract on lipopolysaccharide (LPS)stimulated RAW 264.7 cells. Purslane extracts significantly reduced LPS-induced synthesis of NO in a dose-dependent manner, as well as the expression levels of iNOS and COX-2. The productions of TNF-alpha and IL-6 were also significantly reduced at the higher dose of 400 mu g/ml. Meanwhile, the expression levels of P65, p-P65, p-MEK and p-I kappa B-alpha were inhibited dose-dependently. The nuclear translocation of P65 was partially prevented by the extract, which explained the inhibition of NF-kappa B pathway. In addition, three reported flavonoids, named luteolin, kaempferol and quercitrin, were identified in the extract, which might be responsible for its anti-inflammatory effects. Above all, our research has partially proved that purslane could be considered as a natural anti-inflammatory agent in further applications.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Tao, HongxunUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (author)
  • Peng, YuUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (author)
  • Wang, ShengpengUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (author)
  • Zhong, ZhangfengUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (author)
  • El-Seedi, HeshamUppsala universitet,Farmakognosi(Swepub:uu)heels173 (author)
  • Dragan, SimonaUniv Med & Farm Timisoara, 2 Eftimie Murgu Sq, Timisoara 300041, Romania (author)
  • Zengin, GokhanSelcuk Univ, Sci Fac, Dept Biol, Konya, Turkey (author)
  • Cheang, Wai SanUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (author)
  • Wang, YitaoUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (author)
  • Xiao, JianboUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (author)
  • Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R ChinaFarmakognosi (creator_code:org_t)

Related titles

  • In:Food Chemistry: ELSEVIER SCI LTD290, s. 239-2450308-81461873-7072

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