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- Ho, Ada M-CMayo Clin, Dept Psychiat & Psychol, Rochester, MN, USA (author)
Correlations between sex-related hormones, alcohol dependence and alcohol craving
- Article/chapterEnglish2019
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- Elsevier BV,2019
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-382988
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382988URI
- https://doi.org/10.1016/j.drugalcdep.2019.01.029DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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- Background: Sex-related differences in the susceptibility, progression, and treatment response in alcohol-dependent subjects have been repeatedly reported. In this study, we aimed to investigate the associations of the sex-related hormone/protein levels with alcohol dependence (AD) and alcohol craving in male and female subjects.Methods: Plasma sex-related hormones (estradiol, estrone, total testosterone, progesterone, follicle stimulated hormone [FSH], luteinizing hormone), and sex hormone binding globulin were measured by mass spectrometry or automated immunoassays from 44 recently-abstained subjects (29 males and 15 females; mean age = 45.9 ± 15.6) meeting DSM-IV-TR criteria for AD and 44 age-, sex- and race-matched non-AD controls. Conditional logistic regression was conducted to examine the association of sex-related hormone and protein levels with AD risk, accounting for matching variables. Their associations with alcohol craving scales (Penn Alcohol Craving Scale and Inventory of Drug-Taking Situations) were assessed in AD subjects.Results: Plasma FSH level was significantly higher in AD males (10.3 ± 9.8 IU/L) than control males (8.0 ± 15.9 IU/L; p = 0.005, pcorrected = 0.035). We also found a significant inverse correlation of FSH level with propensity to drink in negative emotional situations (Spearman’s rho=-.540; p = 0.021) and positive correlations between progesterone level and craving intensity (Spearman’s rho=.464; p = 0.020) and between total testosterone level and propensity to drink under temptations (adjusted for no-drinking days; β=6.496; p = 0.041) in AD males.Conclusions: These results suggest that FSH, progesterone, and testosterone levels may be associated with AD and alcohol craving in AD males. Future research is needed to replicate these findings and investigate the underlying biological mechanisms.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Beroendelära hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Substance Abuse hsv//eng
- Alcohol use disorders
- Alcohol dependence
- Craving
- Sex differences
- Sex hormones
Added entries (persons, corporate bodies, meetings, titles ...)
- Geske, Jennifer R.Mayo Clin, Dept Hlth Sci Res, Rochester, MN, USA (author)
- Bakalkin, GeorgyUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)gueba200 (author)
- Winham, Stacey J.Mayo Clin, Dept Hlth Sci Res, Rochester, MN, USA (author)
- Karpyak, Victor M.Mayo Clin, Dept Psychiat & Psychol, Rochester, MN, USA (author)
- Mayo Clin, Dept Psychiat & Psychol, Rochester, MN, USAMayo Clin, Dept Hlth Sci Res, Rochester, MN, USA (creator_code:org_t)
Related titles
- In:Drug And Alcohol Dependence: Elsevier BV197, s. 183-1900376-87161879-0046
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