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Menopausal hormone ...
Menopausal hormone therapy and breast cancer risk : effect modification by body mass through life
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- Sandvei, Marie Søfteland (författare)
- Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway; Nordland Hosp Bodo, Dept Canc & Palliat Care, Bodo, Norway; Univ Tromso, Dept Clin Med, Tromso, Norway
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- Vatten, Lars J. (författare)
- Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway
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- Bjelland, Elisabeth Krefting (författare)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Akershus Univ Hosp, Dept Obstet & Gynecol, Lorenskog, Norway
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- Eskild, Anne (författare)
- Akershus Univ Hosp, Dept Obstet & Gynecol, Lorenskog, Norway; Univ Oslo, Inst Clin Med, Campus Ahus, Oslo, Norway
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- Hofvind, Solveig (författare)
- Canc Registry Norway, Inst Populat Based Res, Oslo, Norway
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- Ursin, Giske (författare)
- Canc Registry Norway, Inst Populat Based Res, Oslo, Norway; Univ Oslo, Inst Basic Med Sci, Oslo, Norway; Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA
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- Opdahl, Signe (författare)
- Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway
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(creator_code:org_t)
- 2018-08-06
- 2019
- Engelska.
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Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 34:3, s. 267-278
- Relaterad länk:
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https://www.duo.uio....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- It is not known whether increased breast cancer risk caused by menopausal hormone therapy (HT) depends on body mass patterns through life. In a prospective study of 483,241 Norwegian women aged 50–69 years at baseline, 7656 women developed breast cancer during follow-up (2006–2013). We combined baseline information on recalled body mass in childhood/adolescence and current (baseline) body mass index (BMI) to construct mutually exclusive life-course body mass patterns. We assessed associations of current HT use with breast cancer risk according to baseline BMI and life-course patterns of body mass, and estimated relative excess risk due to interaction (RERI). Within all levels of baseline BMI, HT use was associated with increased risk. Considering life-course body mass patterns as a single exposure, we used women who “remained at normal weight” through life as the reference, and found that being “overweight as young” was associated with lower risk (hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.76–0.94), whereas women who “gained weight” had higher risk (HR 1.20, 95% CI 1.12–1.28). Compared to never users of HT who were “overweight as young”, HT users who either “remained at normal weight” or “gained weight” in adulthood were at higher risk than expected when adding the separate risks (RERI 0.52, 95% CI 0.09–0.95, and RERI 0.37, 95% CI − 0.07–0.80), suggesting effect modification. Thus, we found that women who remain at normal weight or gain weight in adulthood may be more susceptible to the risk increasing effect of HT compared to women who were overweight as young.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Breast cancer
- Menopausal hormone therapy
- Body-mass index
- Epidemiology
- Cohort study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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