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Focal traumatic bra...
Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord
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- Kononenko, Olga (author)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Watanabe, Hiroyuki (author)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Stålhandske, Lada (author)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Zarelius, Ann (author)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Clausen, Fredrik, 1973- (author)
- Uppsala University,Uppsala universitet,Neurokirurgi
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- Yakovleva, Tatiana (author)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Bakalkin, Georgy (author)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Marklund, Niklas (author)
- Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Neurokirurgi,Lund Univ, Dept Clin Sci Neurosurg, Skane Univ Hosp, EA Blocket,4th Floor,Box 188, S-22100 Lund, Sweden,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Forskargrupper vid Lunds universitet,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research,Lund University Research Groups
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- IOS PRESS, 2019
- 2019
- English.
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In: Restorative Neurology and Neuroscience. - : IOS PRESS. - 0922-6028 .- 1878-3627. ; 37:2, s. 87-96
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Abstract
Subject headings
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- Background/Objectives: Motor impairment induced by traumatic brain injury (TBI) may be mediated through changes in spinal molecular systems regulating neuronal plasticity. We assessed whether a focal controlled cortical impact (CCI) TBI in the rat alters expression of the Tgfb1, c-Fos, Bdnf and Gap43 neuroplasticity genes in lumbar spinal cord.Approach/Methods: Adult male Sprague-Dawley rats (n = 8) were subjected to a right-side CCI over the anterior sensorimotor hindlimb representation area or sham-injury (n=8). Absolute expression levels of Tgfb1, c-Fos, Bdnf, and Gapd43 genes were measured by droplet digital PCR in ipsi- and contralesional, dorsal and ventral quadrants of the L4 and L5 spinal cord. The neuronal activity marker c-Fos was analysed by immunohistochemistry in the dorsal L4 and L5 segments. The contra- vs. ipsilesional expression pattern was examined as the asymmetry index, AI.Results: The Tgfb1 mRNA levels were significantly higher in the CCI vs. sham-injured rats, and in the contra- vs. ipsilesional dorsal domains in the CCI group. The number of c-Fos-positive cells was elevated in the L4 and L5 segments; and on the contralesional compared to the ipsilesional side in the CCI group. The c-Fos AI in the dorsal laminae was significantly increased by CCI.Conclusions: The results support the hypothesis that focal TBI induces plastic alterations in the lumbar spinal cord that may contribute to either motor recovery or maladaptive motor responses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Traumatic brain injury
- Tgfb1
- c-Fos
- spinal cord
- plasticity
- c-Fos
- plasticity
- spinal cord
- Tgfb1
- Traumatic brain injury
Publication and Content Type
- ref (subject category)
- art (subject category)
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