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NETest liquid biops...
NETest liquid biopsy is diagnostic of small intestine and pancreatic neuroendocrine tumors and correlates with imaging
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- Malczewska, Anna (författare)
- Med Univ Silesia, Dept Endocrinol & Neuroendocrine Tumors, Dept Pathophysiol & Endocrinol, Katowice, Poland
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- Witkowska, Magdalena (författare)
- Med Univ Silesia, Dept Endocrinol & Neuroendocrine Tumors, Dept Pathophysiol & Endocrinol, Katowice, Poland
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- Makulik, Karolina (författare)
- Med Univ Silesia, Dept Endocrinol & Neuroendocrine Tumors, Dept Pathophysiol & Endocrinol, Katowice, Poland
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- Bocian, Agnes (författare)
- Med Univ Silesia, Dept Endocrinol & Neuroendocrine Tumors, Dept Pathophysiol & Endocrinol, Katowice, Poland
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- Walter, Agata (författare)
- Med Univ Silesia, Dept Endocrinol & Neuroendocrine Tumors, Dept Pathophysiol & Endocrinol, Katowice, Poland
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- Pilch-Kowalczyk, Joanna (författare)
- Med Univ Silesia, Dept Radiol & Nucl Med, Katowice, Poland
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- Zajecki, Wojciech (författare)
- Med Univ Silesia, Dept Pathol Zabrze, Katowice, Poland
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- Bodei, Lisa (författare)
- Mem Sloan Kettering Canc Ctr, Mol Imaging & Therapy Serv, Dept Radiol, 1275 York Ave, New York, NY 10021 USA
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- Öberg, Kjell, 1946- (författare)
- Uppsala universitet,Endokrin tumörbiologi
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- Kos-Kudla, Beata (författare)
- Med Univ Silesia, Dept Endocrinol & Neuroendocrine Tumors, Dept Pathophysiol & Endocrinol, Katowice, Poland
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(creator_code:org_t)
- BIOSCIENTIFICA LTD, 2019
- 2019
- Engelska.
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Ingår i: Endocrine Connections. - : BIOSCIENTIFICA LTD. - 2049-3614. ; 8:4, s. 442-453
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Introduction: Current monoanalyte biomarkers are ineffective in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). NETest, a novel multianalyte signature, provides molecular information relevant to disease biology. Aim(s): Independently validate NETest to diagnose GEP-NETs and identify progression in a tertiary referral center. Materials and methods: Cohorts are 67 pancreatic NETs (PNETs), 44 small intestine NETs (SINETs) and 63 controls. Well-differentiated (WD) PNETs, n = 62, SINETs, all (n = 44). Disease extent assessment at blood draw: anatomical (n = 110) CT (n = 106), MRI (n = 7) and/or functional Ga-68-SSA-PET/CT (n = 69) or F-18-FDG-PET/CT (n = 8). Image-positive disease (IPD) was defined as either CT/MRI or Ga-68-SSA-PET/CT/F-18-FDG-PET/CT-positive. Both CT/MRI and Ga-68-SSA-PET/CT negative diagnosis in WD-NETs was considered image-negative disease (IND). NETest (normal: 20): PCR (spotted plate s). Data: mean +/- SD. Results: Diagnosis: NETest was significantly increased in NETs (n = 111; 26 +/- 21) vs controls (8 +/- 4, p < 0.0001). Seventy-five (42 PNET, 33 SINET) were image positive. Eleven (8 PNET, 3 SINET; all WD) were IND. In IPD, NETest was significantly high er (36 +/- 22) vs IND (8 +/- 7, P < 0.0001). NETest accuracy, sensitivity and specificity are 97, 99 and 95%, respectively. Concordance with imaging: NETest was 92% (101/110) concordant with anatomical imaging, 94% (65/69) with Ga-68-SSA-PET/CT and 96% (65/68) dual modality (CT/MRI and Ga-68-SSA-PET/CT). In 70 CT/MRI positive, NETest was elevated in all (37 +/- 22). In 40 CT/MRI negative, NETest was normal (11 +/- 10) in 31. In 56 Ga-68-SSA-PET/CT positive, NETest was elevated (36 +/- 22) in 55. In 13 Ga-68-SSA-PET/CT negative, NETest was normal (9 +/- 8) in ten. Disease status: NETest was significantly higher in progressive (61 +/- 26; n = 11) vs stable disease (29 +/- 14; n = 64; P < 0.0001) (RECIST 1.1). Conclusion: NETest is an effective diagnostic for PNETs and SINETs. Elevated NETest is as effective as imaging in diagnosis and accurately identifies progression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- NETest
- liquid biopsy
- biomarker
- gastroenteropancreatic
- imaging
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- ref (ämneskategori)
- art (ämneskategori)
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Malczewska, Anna
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Witkowska, Magda ...
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Makulik, Karolin ...
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Bocian, Agnes
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Walter, Agata
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Pilch-Kowalczyk, ...
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Zajecki, Wojciec ...
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Bodei, Lisa
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Öberg, Kjell, 19 ...
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Kos-Kudla, Beata
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