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Genetic variant pre...
Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer
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- Bien, Stephanie A. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Su, Yu-Ru (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Conti, David V. (författare)
- Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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visa fler...
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- Harrison, Tabitha A. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Qu, Conghui (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Guo, Xingyi (författare)
- Vanderbilt Univ, Sch Med, Div Epidemiol, Nashville, TN 37232 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Lu, Yingchang (författare)
- Vanderbilt Univ, Sch Med, Div Epidemiol, Nashville, TN 37232 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Albanes, Demetrius (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Auer, Paul L. (författare)
- Karolinska Institutet
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- Banbury, Barbara L. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Berndt, Sonja I. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Bezieau, Stephane (författare)
- CHU Hotel Dieu, F-44093 Nantes, France;CHU Nantes, Serv Genet Med, F-44093 Nantes, France;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA,Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Brenner, Hermann (författare)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany;Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany;German Canc Consortium DKTK, D-69120 Heidelberg, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Buchanan, Daniel D. (författare)
- Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia;Univ Melbourne, Dept Pathol, Colorectal Oncogen Grp, Melbourne, Vic 3010, Australia;Royal Melbourne Hosp, Genet Med & Familial Canc Ctr, Parkville, Vic 3010, Australia;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Caan, Bette J. (författare)
- Kaiser Permanente Med Care Program Northern Calif, Div Res, Oakland, CA 94612 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Campbell, Peter T. (författare)
- Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Carlson, Christopher S. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA,Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Chan, Andrew T. (författare)
- Harvard Med Sch, Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Chang-Claude, Jenny (författare)
- German Canc Res Ctr, Div Canc Epidemiol, Unit Genet Epidemiol, D-69120 Heidelberg, Germany;Univ Canc Ctr Hamburg, Univ Med Ctr Hamburg, Genet Tumour Epidemiol Grp, D-20246 Hamburg, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Chen, Sai (författare)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Connolly, Charles M. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA,Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Easton, Douglas F. (författare)
- Univ Cambridge, Dept Publ Hlth, Cambridge, England;Univ Cambridge, Primary Care Sch Clin Med, Cambridge, England;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Feskens, Edith J. M. (författare)
- Wageningen Univ & Res, Div Human Nutr, Wageningen, Netherlands;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Gallinger, Steven (författare)
- Univ Toronto, Lunenfeld Tanenbaum Res Inst, Mt Sinai Hosp, Toronto, ON ON 1X5, Canada;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Giles, Graham G. (författare)
- Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Gunter, Marc J. (författare)
- Aarhus Univ, Sect Epidemiol, Dept Publ Hlth, Aarhus, Denmark;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Hampe, Jochen (författare)
- Univ Hosp Dresden, Med Dept 1, TU Dresden, D-01307 Dresden, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Huyghe, Jeroen R. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Hoffmeister, Michael (författare)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Hudson, Thomas J. (författare)
- Ontario Inst Canc Res, Toronto, ON, Canada;AbbVie Inc, 1500 Seaport Blvd, Redwood City, CA 94063 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Jacobs, Eric J. (författare)
- Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Jenkins, Mark A. (författare)
- Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Kampman, Ellen (författare)
- Wageningen Univ & Res, Div Human Nutr, Wageningen, Netherlands;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Kang, Hyun Min (författare)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Kuehn, Tilman (författare)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Kury, Sebastien (författare)
- CHU Hotel Dieu, F-44093 Nantes, France;CHU Nantes, Serv Genet Med, F-44093 Nantes, France;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Lejbkowicz, Flavio (författare)
- Natl Israeli Canc Control Ctr, Clalit Hlth Serv, IL-34361 Haifa, Israel;Carmel Hosp, Dept Community Med & Epidemiol, IL-34361 Haifa, Israel;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Le Marchand, Loic (författare)
- Univ Hawaii, Canc Ctr, Honolulu, HI 96813 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Milne, Roger L. (författare)
- Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Li, Li (författare)
- Case Western Reserve Univ, Dept Family Med & Community Hlth, Cleveland, OH 44106 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA,H Lee Moffitt Canc Ctr & Res Inst Inc, Dept Canc Epidemiol, Tampa, FL 33612 USA;H Lee Moffitt Canc Ctr & Res Inst Inc, Dept Gastrointestinal Oncol, Tampa, FL 33612 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA,Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Li, Christopher I. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Lindblom, Annika (författare)
- Karolinska Univ, Hosp Solna, Dept Clin Genet, S-17177 Stockholm, Sweden;Karolinska Inst Solna, Dept Mol Med & Surg, S-17177 Stockholm, Sweden;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Lindor, Noralane M. (författare)
- Mayo Clin Arizona, Dept Hlth Sci Res, Scottsdale, AZ 85259 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Martin, Vicente (författare)
- Univ Leon, Biomed Inst IBIOMED, Leon, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- McNeil, Caroline E. (författare)
- Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Melas, Marilena (författare)
- Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA,Huntsman Canc Inst, Populat Sci, Salt Lake City, UT 84112 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Moreno, Victor (författare)
- CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain;Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Barcelona 08028, Spain;Univ Barcelona, E-08007 Barcelona, Spain;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Newcomb, Polly A. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Offit, Kenneth (författare)
- Mem Sloan Kettering Canc Ctr, Clin Genet Serv, Dept Med, New York, NY 10065 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Pharaoh, Paul D. P. (författare)
- Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Potter, John D. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Qu, Chenxu (författare)
- Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Riboli, Elio (författare)
- Imperial Coll London, Sch Publ Hlth, London, England;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Rennert, Gad (författare)
- Natl Israeli Canc Control Ctr, Clalit Hlth Serv, IL-34361 Haifa, Israel;Carmel Hosp, Dept Community Med & Epidemiol, IL-34361 Haifa, Israel;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Sala, Nuria (författare)
- Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Program, Unit Nutr & Canc, Barcelona 08908, Spain;Catalan Inst Oncol IDIBELL, Mol Epidemiol Grp, Translat Res Lab, Barcelona 08908, Spain;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Schafmayer, Clemens (författare)
- Univ Hosp Schleswig Holstein, Dept Gen & Thorac Surg, Campus Kiel, D-24118 Kiel, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Scacheri, Peter C. (författare)
- Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Schmit, Stephanie L. (författare)
- H Lee Moffitt Canc Ctr & Res Inst Inc, Dept Canc Epidemiol, Tampa, FL 33612 USA;H Lee Moffitt Canc Ctr & Res Inst Inc, Dept Gastrointestinal Oncol, Tampa, FL 33612 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Severi, Gianluca (författare)
- Inst Cancerol Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Slattery, Martha L. (författare)
- Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Smith, Joshua D. (författare)
- Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Trichopoulou, Antonia (författare)
- Hellen Hlth Fdn, 13 Kaisareias & Alexandroupoleos, Athens 11527, Greece;Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutrit Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Med Sch, Mikras Asias 11527, Greece;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Tumino, Rosario (författare)
- Azienda Sanit Prov Ragusa, Dept Prevent, Affiliat Canc Registry, Ragusa, Italy;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Ulrich, Cornelia M. (författare)
- Huntsman Canc Inst, Populat Sci, Salt Lake City, UT 84112 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- van Duijnhoven, Franzel J. B. (författare)
- Wageningen Univ & Res, Div Human Nutr, Wageningen, Netherlands;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- van Guelpen, Bethany (författare)
- Umeå universitet,Patologi,Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, USA,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Weinstein, Stephanie J. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- White, Emily (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Wolk, Alicja (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst Solna, Inst Environm Med, S-17177 Stockholm, Sweden;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Woods, Michael O. (författare)
- Mem Univ Newfoundland, Fac Med, Discipline Genet, St John, NF A1B 3V6, Canada;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Wu, Anna H. (författare)
- Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Abecasis, Goncalo R. (författare)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Casey, Graham (författare)
- Inst Cancerol Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Nickerson, Deborah A. (författare)
- Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Gruber, Stephen B. (författare)
- Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Hsu, Li (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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- Zheng, Wei (författare)
- Vanderbilt Univ, Sch Med, Div Epidemiol, Nashville, TN 37232 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA;Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA
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- Peters, Ulrike (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA
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(creator_code:org_t)
- 2019-02-28
- 2019
- Engelska.
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Ingår i: Human Genetics. - : Springer. - 0340-6717 .- 1432-1203. ; 138:4, s. 307-326
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational method PrediXcan uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured transcriptomes. In this study, we used reference datasets from colon (n=169) and whole blood (n=922) transcriptomes to test CRC association with genetically determined expression levels in a genome-wide analysis of 12,186 cases and 14,718 controls. Three novel associations were discovered from colon transverse models at FDR0.2 and further evaluated in an independent replication including 32,825 cases and 39,933 controls. After adjusting for multiple comparisons, we found statistically significant associations using colon transcriptome models with TRIM4 (discovery P=2.2x10(-4), replication P=0.01), and PYGL (discovery P=2.3x10(-4), replication P=6.7x10(-4)). Interestingly, both genes encode proteins that influence redox homeostasis and are related to cellular metabolic reprogramming in tumors, implicating a novel CRC pathway linked to cell growth and proliferation. Defining CRC risk regions as one megabase up- and downstream of one of the 56 independent risk variants, we defined 44 non-overlapping CRC-risk regions. Among these risk regions, we identified genes associated with CRC (P<0.05) in 34/44 CRC-risk regions. Importantly, CRC association was found for two genes in the previously reported 2q25 locus, CXCR1 and CXCR2, which are potential cancer therapeutic targets. These findings provide strong candidate genes to prioritize for subsequent laboratory follow-up of GWAS loci. This study is the first to implement PrediXcan in a large colorectal cancer study and findings highlight the utility of integrating transcriptome data in GWAS for discovery of, and biological insight into, risk loci.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Bien, Stephanie ...
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Su, Yu-Ru
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Conti, David V.
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Harrison, Tabith ...
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Qu, Conghui
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Guo, Xingyi
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visa fler...
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Lu, Yingchang
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Albanes, Demetri ...
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Auer, Paul L.
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Banbury, Barbara ...
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Berndt, Sonja I.
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Bezieau, Stephan ...
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Brenner, Hermann
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Buchanan, Daniel ...
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Caan, Bette J.
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Campbell, Peter ...
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Carlson, Christo ...
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Chan, Andrew T.
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Chang-Claude, Je ...
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Chen, Sai
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Connolly, Charle ...
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Easton, Douglas ...
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Feskens, Edith J ...
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Gallinger, Steve ...
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Giles, Graham G.
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Gunter, Marc J.
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Hampe, Jochen
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Huyghe, Jeroen R ...
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Hoffmeister, Mic ...
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Hudson, Thomas J ...
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Jacobs, Eric J.
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Jenkins, Mark A.
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Kampman, Ellen
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Kang, Hyun Min
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Kuehn, Tilman
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Kury, Sebastien
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Lejbkowicz, Flav ...
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Le Marchand, Loi ...
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Milne, Roger L.
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Li, Li
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Li, Christopher ...
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Lindblom, Annika
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Lindor, Noralane ...
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Martin, Vicente
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McNeil, Caroline ...
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Melas, Marilena
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Moreno, Victor
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Newcomb, Polly A ...
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Offit, Kenneth
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Pharaoh, Paul D. ...
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Potter, John D.
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Qu, Chenxu
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Riboli, Elio
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Rennert, Gad
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Sala, Nuria
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Schafmayer, Clem ...
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Scacheri, Peter ...
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Schmit, Stephani ...
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Severi, Gianluca
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Slattery, Martha ...
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Smith, Joshua D.
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Trichopoulou, An ...
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Tumino, Rosario
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Ulrich, Cornelia ...
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van Duijnhoven, ...
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van Guelpen, Bet ...
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Weinstein, Steph ...
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White, Emily
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Wolk, Alicja
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Woods, Michael O ...
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Wu, Anna H.
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Abecasis, Goncal ...
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Casey, Graham
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Nickerson, Debor ...
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Gruber, Stephen ...
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Hsu, Li
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Zheng, Wei
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Peters, Ulrike
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Human Genetics
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Karolinska Institutet