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Family Mismatched A...
Family Mismatched Allogeneic Stem Cell Transplantation for Myelofibrosis : Report from the Chronic Malignancies Working Party of European Society for Blood and Marrow Transplantation
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- Raj, Kavita (författare)
- Guys & St Thomas NHS Fdn Trust, Dept Haematol Med, London, England
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- Eikema, Diderik-Jan (författare)
- EBMT Stat Unit, Dept Med Stat & Bioinformat, Leiden, Netherlands
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- McLornanl, Donal P. (författare)
- Guys & St Thomas NHS Fdn Trust, Dept Haematol Med, London, England
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- Olavarria, Eduardo (författare)
- Hammersmith Hosp London, Dept Haematol Med, London, England
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- Bloke, Henric-Jan (författare)
- EBMT Stat Unit, Dept Med Stat & Bioinformat, Leiden, Netherlands
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- Bregante, Stefania (författare)
- Osped San Martino Genova, Dept Haematol, Genoa, Italy
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- Ciceri, Fabio (författare)
- Carattere Sci San Raffaele Sci Inst, Dept Hematol & Hematopoiet, Milan, Italy
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- Passweg, Jakob (författare)
- Univ Hosp, Dept Internal Med, Basel, Switzerland
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- Ljungman, Per (författare)
- Karolinska Institutet
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- Schaap, Nicolaas (författare)
- Radboud Univ Nijmegen, Med Ctr, Dept Hematol, Nijmegen, Netherlands
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- Carlson, Kristina (författare)
- Uppsala universitet,Hematologi
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- Zuckerman, Tsila (författare)
- Rambam Med Ctr, Depatment Hematol & Bone Marrow Transplantat, Haifa, Israel
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- de Wreede, Liesbeth C. (författare)
- Deutsch Knochenmarkspenderdatei Clin Trials Unit, Dresden, Germany
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- Volin, Liisa (författare)
- Helsinki Univ Cent Hosp, Ctr Comprehens Canc, Dept Med, Helsinki, Finland
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- Koc, Yener (författare)
- Med Pk Hosp, Stem Cell Transplant Unit, Dept Oncol, Antalya, Turkey
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- Luis Diez-Martin, Jose (författare)
- Univ Complutense Med, Inst Invest Sanitaria Gregorio Maranon, Dept Hematol, Madrid, Spain
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- Brossart, Peter (författare)
- Univ Bonn, Dept Immunooncol & Rheumatol, Bonn, Germany
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- Wolf, Dominik (författare)
- Univ Bonn, Dept Immunooncol & Rheumatol, Bonn, Germany
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- Blaise, Didier (författare)
- Inst Paoli Calmettes, Transplantat & Cell Therapy Unit, Dept Oncohematol, Marseille, France
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- Di Bartolomeo, Paolo (författare)
- Osped Civile, Dept Hematol Transfus Med & Biotechnol, Marseille, France
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- Vitek, Antonin (författare)
- Inst Hematol & Blood Transfus, Prague, Czech Republic
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- Robin, Marie (författare)
- Hop St Louis, Dept Hematol & Bone Marrow Transplantat, Paris, France
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- Yakoub-Agha, Ibrahim (författare)
- Univ Lille, Lille Univ Hosp, INSERM U995, Dept Hematol, Lille, France
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- Chalandon, Yves (författare)
- Univ Geneva, Hematol Div, Hop Univ Geneve, Geneva, Switzerland
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- Kroger, Nicolaus (författare)
- Univ Hosp Eppendorf, Dept Stem Cell Transplantat, Hamburg, Germany
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 25:3, s. 522-528
- Relaterad länk:
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http://www.bbmt.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- This analysis included 56 myelofibrosis (MF) patients transplanted from family mismatched donor between 2009 and 2015 enrolled in the European Society for Blood and Marrow Transplantation database. The median age was 57 years (range, 38 to 72); 75% had primary MF and 25% had secondary MF. JAK2 V617F was mutated in 61%. Donors were HLA mismatched at 2 or more loci. Stem cells were sourced from bone marrow in 66% and peripheral blood in 34%. The median CD34(+) cell dose was 4.8 x 10(6)/kg (range, 1.7 to 22.9; n = 43). Conditioning was predominantly myeloablative in 70% and reduced intensity in the remainder. Regimens were heterogeneous with thiotepa, busulfan, fludarabine, and post-transplant cyclophosphamide used in 59%. The incidence of neutrophil engraftment by 28 days was 82% (range, 70% to 93%), at a median of 21 days (range, 19 to 23). At 2 years the cumulative incidence of primary graft failure was 9% (95% CI 1% to 16%) and secondary graft failure was 13% (95% CI 4% to 22%). The cumulative incidence of acute graft-versus-host disease (GVHD) grades II to IV and Ill to IV was 28% (95% CI 16% to 40%) and 9% (95% CI 2% to 17%) at 100 days. The cumulative incidence of chronic GVHD at 1 year was 45% (95% CI 32% to 58%), but the cumulative incidence of death without chronic GVHD by 1 year was 20% (95% CI 10% to 31%). With a median follow-up of 32 months, the 1- and 2-year overall survival was 61% (95% CI 48% to 74%) and 56% (95% CI 41% to 70%), respectively. The 1- and 2- year progression-free survival was 58% (95% CI 45% to 71%) and 43% (95% CI 28% to 58%), respectively, with a 2-year cumulative incidence of relapse of 19% 95% CI 7% to 31%). The 2-year nonrelapse mortality was 38% (95% CI 24% to 51%). This retrospective study of MF allo-SCT using family mismatched donors demonstrated feasibility of the approach, timely neutrophil engraftment in over 80% of cases, and acceptable overall and progression-free survival rates with relapse rates not dissimilar to the unrelated donor setting. However, strategies to minimize the risk of graft failure and the relatively high nonrelapse mortality need to be used, ideally in a multicenter prospective fashion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Myelofibrosis
- Haploidentical
- Mismatched related donor
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Raj, Kavita
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Eikema, Diderik- ...
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McLornanl, Donal ...
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Olavarria, Eduar ...
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Bloke, Henric-Ja ...
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Bregante, Stefan ...
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Ciceri, Fabio
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Passweg, Jakob
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Ljungman, Per
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Schaap, Nicolaas
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Carlson, Kristin ...
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Zuckerman, Tsila
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de Wreede, Liesb ...
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Volin, Liisa
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Koc, Yener
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Luis Diez-Martin ...
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Brossart, Peter
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Wolf, Dominik
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Blaise, Didier
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Di Bartolomeo, P ...
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Vitek, Antonin
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Robin, Marie
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Yakoub-Agha, Ibr ...
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Chalandon, Yves
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Kroger, Nicolaus
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