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A Peripheral Blood ...
A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease
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- Ma, Jiantao (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Tufts Univ, Nutr Data Sci, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
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- Nano, Jana (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Neuherberg, Germany;German Ctr Diabet Res, Munich, Germany
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- Ding, Jingzhong (author)
- Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA
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- Zheng, Yinan (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
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- Hennein, Rachel (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
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- Liu, Chunyu (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Boston Univ, Dept Biostat, Boston, MA 02215 USA
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- Speliotes, Elizabeth K. (author)
- Univ Michigan, Sch Med, Ann Arbor, MI USA
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- Huan, Tianxiao (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
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- Song, Ci (author)
- Uppsala universitet,Molekylär epidemiologi,NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
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- Mendelson, Michael M. (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Harvard Med Sch, Dept Cardiol, Boston Childrens Hosp, Boston, MA 02115 USA
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- Joehanes, Roby (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
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- Long, Michelle T. (author)
- Boston Univ, Sch Med, Dept Med, Gastroenterol Sect, Boston, MA 02118 USA
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- Liang, Liming (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
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- Smith, Jennifer A. (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
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- Reynolds, Lindsay M. (author)
- Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA
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- Ghanbari, Mohsen (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Razavi Khorasan, Iran
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- Muka, Taulant (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
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- van Meurs, Joyce B. J. (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
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- Alferink, Louise J. M. (author)
- Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
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- Franco, Oscar H. (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
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- Dehghan, Abbas (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Imperial Coll London, Dept Biostat & Epidemiol, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England
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- Ratliff, Scott (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
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- Zhao, Wei (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
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- Bielak, Lawrence (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
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- Kardia, Sharon L. R. (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
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- Peyser, Patricia A. (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
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- Ning, Hongyan (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
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- VanWagner, Lisa B. (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA;Northwestern Univ, Dept Med, Feinberg Sch Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA
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- Lloyd-Jones, Donald M. (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
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- Carr, John Jeffrey (author)
- Vanderbilt Univ, Med Ctr, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA
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- Greenland, Philip (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
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- Lichtenstein, Alice H. (author)
- Tufts Univ, USDA, Human Nutr Res Ctr Aging, Cardiovasc Nutr Lab, Boston, MA 02111 USA
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- Hu, Frank B. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
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- Liu, Yongmei (author)
- Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA
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- Hou, Lifang (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
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- Murad, Sarwa Darwish (author)
- Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
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- Levy, Daniel (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
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(creator_code:org_t)
- AMER DIABETES ASSOC, 2019
- 2019
- English.
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In: Diabetes. - : AMER DIABETES ASSOC. - 0012-1797 .- 1939-327X. ; 68:5, s. 1073-1083
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of hepatic fat. We conducted epigenome-wide association studies of hepatic fat in 3,400 European ancestry (EA) participants and in 401 Hispanic ancestry and 724 African ancestry participants from four population-based cohort studies. Hepatic fat was measured using computed tomography or ultrasound imaging and DNA methylation was assessed at >400,000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ monocytes using a commercial array. We identified 22 CpGs associated with hepatic fat in EA participants at a false discovery rate <0.05 (corresponding P = 6.9 x 10(-6)) with replication at Bonferroni-corrected P < 8.6 x 10(-4). Mendelian randomization analyses supported the association of hypomethylation of cg08309687 (LINC00649) with NAFLD (P = 2.5 x 10(-4)). Hypomethylation of the same CpG was also associated with risk for new-onset T2D (P = 0.005). Our study demonstrates that a peripheral blood-derived DNA methylation signature is robustly associated with hepatic fat accumulation. The hepatic fat-associated CpGs may represent attractive biomarkers for T2D. Future studies are warranted to explore mechanisms and to examine DNA methylation signatures of NAFLD across racial/ethnic groups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Diabetes
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To the university's database
- By the author/editor
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Ma, Jiantao
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Nano, Jana
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Ding, Jingzhong
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Zheng, Yinan
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Hennein, Rachel
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Liu, Chunyu
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show more...
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Speliotes, Eliza ...
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Huan, Tianxiao
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Song, Ci
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Mendelson, Micha ...
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Joehanes, Roby
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Long, Michelle T ...
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Liang, Liming
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Smith, Jennifer ...
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Reynolds, Lindsa ...
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Ghanbari, Mohsen
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Muka, Taulant
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van Meurs, Joyce ...
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Alferink, Louise ...
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Franco, Oscar H.
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Dehghan, Abbas
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Ratliff, Scott
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Zhao, Wei
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Bielak, Lawrence
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Kardia, Sharon L ...
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Peyser, Patricia ...
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Ning, Hongyan
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VanWagner, Lisa ...
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Lloyd-Jones, Don ...
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Carr, John Jeffr ...
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Greenland, Phili ...
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Lichtenstein, Al ...
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Hu, Frank B.
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Liu, Yongmei
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Hou, Lifang
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Murad, Sarwa Dar ...
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Levy, Daniel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Diabetes
- By the university
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Uppsala University