(id:"swepub:oai:DiVA.org:uu-383890")
Search: (id:"swepub:oai:DiVA.org:uu-383890") > Change in left vent...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Lind, LarsUppsala universitet,Klinisk epidemiologi (author)
Change in left ventricular geometry over 10 years in the elderly and risk of incident cardiovascular disease
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-383890
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-383890URI
- https://doi.org/10.1097/HJH.0000000000001897DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Objective: Left ventricular hypertrophy (LVH) is related to a poor prognosis. We aimed to determine how left ventricular (LV) geometry changes over time, and how this relates to future cardiovascular disease.Methods: In the Prospective Study of the Vasculature in Uppsala Seniors study, 1016 individuals were investigated with echocardiography at age 70. This was repeated after 5 and 10 years. Incident cardiovascular disease (myocardial infarction, stroke, and heart failure, n = 163) was recorded over 10 years.Results: LV mass index (LVMI) and LV end-diastolic diameter (LVEDD) progressively increased over 10 years, while LV thickness declined (P< 0.0001 for all). Adjusting for traditional cardiovascular risk factors, LVMI at baseline, but not LVEDD, was significantly associated with incident cardiovascular disease [hazard ratio (HR) 1.02, 95% confidence interval 1.003-1.03, P = 0.019]. When adding the change in LVMI, or change in LVEDD, between ages 70 and 75 years to the models and using the time between 75 and 80 as follow-up (in total 82 incident cases), neither the change in LVMI nor the change in LVEDD were significant. Using updated information on LV geometric groups, an increased risk was seen for concentric LVH as compared with the normal group following adjustment for traditional risk factors (HR 2.29, P = 0.0014, 95% confidence interval 1.38-3.82). Eccentric LVH and concentric remodeling were not associated with a statistically significant increased risk of cardiovascular disease.Conclusion: In elderly individuals without myocardial infarction, a progressive dilatation of the LV was seen over 10 years. However, the LV dilation seen over time in this age group was not associated with a major increase in risk of future cardiovascular disease.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- cardiovascular risk
- epidemiology
- left ventricular geometry
Added entries (persons, corporate bodies, meetings, titles ...)
- Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi(Swepub:uu)johasund (author)
- Uppsala universitetKlinisk epidemiologi (creator_code:org_t)
Related titles
- In:Journal of Hypertension37:2, s. 325-3300263-63521473-5598
Internet link
Find in a library
- Journal of Hypertension (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Lind, Lars
- Sundström, Johan ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- Journal of Hyper ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
