Search: (WFRF:(Ahima Rexford S)) >
Transcriptional Bas...
Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron
-
- Cedernaes, Jonathan (author)
- Uppsala universitet,Transplantation och regenerativ medicin,Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
- Huang, Wenyu (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
- Ramsey, Kathryn Moynihan (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
show more...
-
- Waldeck, Nathan (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
- Cheng, Lei (author)
- Northwestern Univ, Weinberg Coll Arts & Sci, Evanston, IL 60208 USA
-
- Marcheva, Biliana (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
- Omura, Chiaki (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
- Kobayashi, Yumiko (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
- Peek, Clara Bien (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
- Levine, Daniel C. (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
- Dhir, Ravindra (author)
- Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
-
- Awatramani, Raj (author)
- Northwestern Univ, Dept Neurol, Feinberg Sch Med, Chicago, IL 60611 USA;Northwestern Univ, Ctr Genet Med, Feinberg Sch Med, Chicago, IL 60611 USA
-
- Bradfield, Christopher A. (author)
- Univ Wisconsin, McArdle Lab Canc Res, Med Sch, Madison, WI 53706 USA
-
- Wang, Xiaozhong A. (author)
- Northwestern Univ, Weinberg Coll Arts & Sci, Dept Mol Sci, Evanston, IL 60208 USA
-
- Takahashi, Joseph S. (author)
- UT Southwestern Med Ctr, Dept Neurosci, Dallas, TX 75390 USA;UT Southwestern Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA
-
- Mokadem, Mohamad (author)
- Univ Iowa, Div Gastroenterol & Hepatol, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA
-
- Ahima, Rexford S. (author)
- Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA
-
- Bass, Joseph (author)
- Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 29:5, s. 1078-1091.e5
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The alignment of fasting and feeding with the sleep/ wake cycle is coordinated by hypothalamic neurons, though the underlying molecular programs remain incompletely understood. Here, we demonstrate that the clock transcription pathway maximizes eating during wakefulness and glucose production during sleep through autonomous circadian regulation of NPY/AgRP neurons. Tandem profiling of whole-cell and ribosome-bound mRNAs in morning and evening under dynamic fasting and fed conditions identified temporal control of activity-dependent gene repertoires in AgRP neurons central to synaptogenesis, bioenergetics, and neurotransmitter and peptidergic signaling. Synaptic and circadian pathways were specific to whole-cell RNA analyses, while bioenergetic pathways were selectively enriched in the ribosome-bound transcriptome. Finally, we demonstrate that the AgRP clock mediates the transcriptional response to leptin. Our results reveal that time-of-day restriction in transcriptional control of energy-sensing neurons underlies the alignment of hunger and food acquisition with the sleep/wake state.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Cedernaes, Jonat ...
-
Huang, Wenyu
-
Ramsey, Kathryn ...
-
Waldeck, Nathan
-
Cheng, Lei
-
Marcheva, Bilian ...
-
show more...
-
Omura, Chiaki
-
Kobayashi, Yumik ...
-
Peek, Clara Bien
-
Levine, Daniel C ...
-
Dhir, Ravindra
-
Awatramani, Raj
-
Bradfield, Chris ...
-
Wang, Xiaozhong ...
-
Takahashi, Josep ...
-
Mokadem, Mohamad
-
Ahima, Rexford S ...
-
Bass, Joseph
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Cell Metabolism
- By the university
-
Uppsala University