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  • Cedernaes, JonathanUppsala universitet,Transplantation och regenerativ medicin,Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Elsevier BV,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-384072
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-384072URI
  • https://doi.org/10.1016/j.cmet.2019.01.023DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De 2 första författarna delar förstaförfattarskapet.
  • The alignment of fasting and feeding with the sleep/ wake cycle is coordinated by hypothalamic neurons, though the underlying molecular programs remain incompletely understood. Here, we demonstrate that the clock transcription pathway maximizes eating during wakefulness and glucose production during sleep through autonomous circadian regulation of NPY/AgRP neurons. Tandem profiling of whole-cell and ribosome-bound mRNAs in morning and evening under dynamic fasting and fed conditions identified temporal control of activity-dependent gene repertoires in AgRP neurons central to synaptogenesis, bioenergetics, and neurotransmitter and peptidergic signaling. Synaptic and circadian pathways were specific to whole-cell RNA analyses, while bioenergetic pathways were selectively enriched in the ribosome-bound transcriptome. Finally, we demonstrate that the AgRP clock mediates the transcriptional response to leptin. Our results reveal that time-of-day restriction in transcriptional control of energy-sensing neurons underlies the alignment of hunger and food acquisition with the sleep/wake state.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Huang, WenyuNorthwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Ramsey, Kathryn MoynihanNorthwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Waldeck, NathanNorthwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Cheng, LeiNorthwestern Univ, Weinberg Coll Arts & Sci, Evanston, IL 60208 USA (author)
  • Marcheva, BilianaNorthwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Omura, ChiakiNorthwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Kobayashi, YumikoNorthwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Peek, Clara BienNorthwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Levine, Daniel C.Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Dhir, RavindraUniv Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA (author)
  • Awatramani, RajNorthwestern Univ, Dept Neurol, Feinberg Sch Med, Chicago, IL 60611 USA;Northwestern Univ, Ctr Genet Med, Feinberg Sch Med, Chicago, IL 60611 USA (author)
  • Bradfield, Christopher A.Univ Wisconsin, McArdle Lab Canc Res, Med Sch, Madison, WI 53706 USA (author)
  • Wang, Xiaozhong A.Northwestern Univ, Weinberg Coll Arts & Sci, Dept Mol Sci, Evanston, IL 60208 USA (author)
  • Takahashi, Joseph S.UT Southwestern Med Ctr, Dept Neurosci, Dallas, TX 75390 USA;UT Southwestern Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA (author)
  • Mokadem, MohamadUniv Iowa, Div Gastroenterol & Hepatol, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA (author)
  • Ahima, Rexford S.Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA (author)
  • Bass, JosephNorthwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA (author)
  • Uppsala universitetTransplantation och regenerativ medicin (creator_code:org_t)

Related titles

  • In:Cell Metabolism: Elsevier BV29:5, s. 1078-1091.e51550-41311932-7420

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