SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:uu-384473"
 

Search: id:"swepub:oai:DiVA.org:uu-384473" > Impact of COPD diag...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Larsson, KjellKarolinska Institutet (author)

Impact of COPD diagnosis timing on clinical and economic outcomes : the ARCTIC observational cohort study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-384473
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-384473URI
  • https://doi.org/10.2147/COPD.S195382DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140921359URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose: Assess the clinical and economic consequences associated with an early versus late diagnosis in patients with COPD.Patients and methods: In a retrospective, observational cohort study, electronic medical record data (2000-2014) were collected from Swedish primary care patients with COPD. COPD indicators (pneumonia, other respiratory diseases, oral corticosteroids, antibiotics for respiratory infections, prescribed drugs for respiratory symptoms, lung function measurement) registered prior to diagnosis were applied to categorize patients into those receiving early (2 or less indicators) or late diagnosis (3 or more indicators registered >90 days preceding a COPD diagnosis). Outcome measures included annual rate of and time to first exacerbation, mortality risk, prevalence of comorbidities and health care utilization.Results: More patients with late diagnosis (n=8827) than with early diagnosis (n=3870) had a recent comorbid diagnosis of asthma (22.0% vs 3.9%; P<0.0001). Compared with early diagnosis, patients with late diagnosis had a higher exacerbation rate (hazard ratio [HR] 1.89, 95% confidence interval [CI]: 1.83-1.96; P<0.0001) and shorter time to first exacerbation (HR 1.61, 95% CI: 1.54-1.69; P<0.0001). Mortality was not different between groups overall but higher for late versus early diagnosis, after excluding patients with past asthma diagnosis (HR 1.10, 95% CI: 1.02-1.18; P=0.0095). Late diagnosis was also associated with higher direct costs than early diagnosis.Conclusion: Late COPD diagnosis is associated with higher exacerbation rate and increased comorbidities and costs compared with early diagnosis. The study highlights the need for accurate diagnosis of COPD in primary care in order to reduce exacerbations and the economic burden of COPD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (author)
  • Ställberg, Björn,DocentUppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)bjsta623 (author)
  • Lisspers, Karin,Docent,1954-Uppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)kalis120 (author)
  • Olsson, PetterNovartis AB, Taby, Sweden (author)
  • Kostikas, KonstantinosNovartis Pharma AG, Basel, Switzerland (author)
  • Gruenberger, Jean-BernardNovartis Pharma AG, Basel, Switzerland (author)
  • Gutzwiller, Florian S.Novartis Pharma AG, Basel, Switzerland (author)
  • Uhde, MilicaIQVIA, Solna, Sweden (author)
  • Jorgensen, LeifIQVIA, Copenhagen, Denmark (author)
  • Johansson, GunnarUppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)gunnarjs (author)
  • Karolinska InstitutetLung- allergi- och sömnforskning (creator_code:org_t)

Related titles

  • In:The International Journal of Chronic Obstructive Pulmonary Disease14, s. 995-10081176-91061178-2005

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view