Sökning: WFRF:(Erlandsson Anna)
> (2015-2019) >
Tumour regression a...
-
Erlandsson, JohanKarolinska Institutet
(författare)
Tumour regression after radiotherapy for rectal cancer - Results from the randomised Stockholm III trial
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
-
ELSEVIER IRELAND LTD,2019
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-385962
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-385962URI
-
https://doi.org/10.1016/j.radonc.2019.03.016DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:140958607URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Background and purpose: Neoadjuvant radiotherapy (RT) in rectal cancer induces tumour regression with a possible complete response (pCR). The optimal fractionation and timing to surgery is not established. The Stockholm III trial randomly assigned 840 patients to 5 x 5 Gy surgery within one week (SRT), 5 x 5 Gy with surgery after 4-8 weeks, and 2 Gy x 25 with surgery after 4-8 weeks (LRT-delay). The aim of this substudy was to assess tumour regression and correlation to survival. Material and methods: All available microscopy slides were assessed by one pathologist, blinded to treatment, regarding tumour regression, graded according to the Dworak system (TRG), TNM-stage and other standard histopathology characteristics. Patients' data were collected from the Swedish ColoRectal Cancer Registry. Outcomes were TRG, pCR-rates, overall survival (OS) and time to recurrence (TTR). Results: 318, 285 and 94 patients were included in the SRT, SRT-delay and LRT-delay groups. Median follow up was 5.7 years. There were significantly lower tumour stages after SRT-delay. pCR was seen in 1 (0.3%), 29 (10.4%) and 2 (2.2%) patients in SRT, SRT-delay and LRT-delay, respectively. The pCR and Dworak grade 4 were associated with superior survival. pCR vs no-pCR Hazard Ratio (95% Confidence Interval) OS: 0.51 (0.26-0.99) p = 0.046, TTR: 0.27 (0.09-0.86) p = 0.027. Conclusion: SRT-delay induces pCR in about 10% of the patients and is in this aspect superior to 25 x 2 Gy. A complete tumour response, TRG 4 using the Dworak system, or a pCR, is associated with superior OS and TTR.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Lorinc, EsterSkane Univ Hosp, Dept Pathol & Cytol, Div Pathol Lund, Lund, Sweden;Dept Clin Sci, Div Oncol & Pathol, Barngatan 2B, SE-22185 Lund, Sweden
(författare)
-
Ahlberga, MadeleneKarolinska Inst, Dept Mol Med & Surg, Solna, Sweden;Karolinska Univ Hosp, Dept Colorectal Canc, Stockholm, Sweden;Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, S-17176 Stockholm, Sweden
(författare)
-
Pettersson, DavidKarolinska Inst, Dept Mol Med & Surg, Solna, Sweden;Norrtalje Sjukhus, Dept Surg, Norrtalje, Sweden;TioHundra AB, Kirurgmottagningen, Box 905, S-76129 Norrtalje, Sweden
(författare)
-
Holm, TorbjornKarolinska Institutet
(författare)
-
Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim
(författare)
-
Martling, AnnaKarolinska Institutet
(författare)
-
Karolinska InstitutetSkane Univ Hosp, Dept Pathol & Cytol, Div Pathol Lund, Lund, Sweden;Dept Clin Sci, Div Oncol & Pathol, Barngatan 2B, SE-22185 Lund, Sweden
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Radiotherapy and Oncology: ELSEVIER IRELAND LTD135, s. 178-1860167-81401879-0887
Internetlänk
Hitta via bibliotek
Till lärosätets databas