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  • Daskalakis, KosmasUppsala universitet,Endokrinkirurgi,Univ Athens, Laiko Hosp, Dept Propauped Internal Med 1, Oncol Unit, Athens, Greece,Uppsala Univ, Sweden; Univ Athens, Greece (author)

Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2018-10-02
  • SPRINGER,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-386165
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-386165URI
  • https://doi.org/10.1007/s12020-018-1773-3DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140985040URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158354URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De två första författarna delar förstaförfattarskapet.
  • Funding Agencies|Lennander Scholaship Fund
  • Objective: Our aim was to assess the prevalence of endocrine paraneoplastic syndromes (EPNS) in neuroendocrine neoplasms (NENs) and estimate its impact on patient outcomes.Design: This is a retrospective analysis of 834 patients with NENs (611 gastrointestinal, 166 thoracic, 57 of unknown and various other primary origin). We included 719 consecutive NEN patients treated at EKPA-Laiko Hospital, Athens, Greece and 115 patients with lung carcinoid (LC) treated at Uppsala University Hospital, Uppsala, Sweden. EPNS diagnosis was based on standard criteria.Methods: Twenty-one patients with EPNS were detected: 16 with ectopic Cushing's syndrome (ECS), one with hypercalcaemia due to parathyroid hormone-related protein (PTHrP) secretion, three with hypercalcitonaemia and one patient with dual secretion of calcitonin and beta-human chorionic gonadotropin (-HCG). All tumours were well-differentiated; 10 patients had Stage IV disease at diagnosis.Results: The prevalence of EPNS in the Greek cohort was 1.9%, whereas that of ECS among LC patients in both centres was 6.7%. Median overall survival (OS) for patients with EPNS was 160.7 months (95%CI, 86-235.4) and median event-free survival (EFS) was 25.9 months (95%CI, 0-57.2). Patients presenting with EPNS prior to NEN diagnosis had longer EFS compared to patients with synchronous or metachronous EPNS (log-rank P=0.013). Patients with ECS of extra-thoracic origin demonstrated shorter OS and EFS compared to patients with ECS of lung or thymic origin (log-rank P=0.001 and P<0.001, respectively). LC patients with and without ECS were comparable in 5-year and 10-year OS rates (66.7% and 33.3% versus 89.8% and 60.2%, respectively; 95%CI [189.6-300.4 months], log-rank P=0.94) and in median EFS, 67 versus 183 months, 95%CI [50.5-207.5], log-rank P=0.12).Conclusion: EPNS are relatively rare in patients with NENs and mainly concern well-differentiated tumours of the foregut. Among patients with EPNS, LC-related ECS may not adversely affect patient outcomes when diagnosed prior to NEN and effectively been treated.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Chatzelis, EleftheriosUniv Athens, Laiko Hosp, Dept Propauped Internal Med 1, Oncol Unit, Athens, Greece;251 Hellen Air Force & VA Gen Hosp, Athens, Greece (author)
  • Tsoli, MarinaUniv Athens, Laiko Hosp, Dept Propauped Internal Med 1, Oncol Unit, Athens, Greece (author)
  • Papadopoulou, NektariaLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)nekpa42 (author)
  • Dimitriadis, Georgios K.Univ Hosp Coventry & Warwickshire NHS Trust, Arden Net CoE & Human Metab Res Unit HMRU, WISDEM, Coventry CV2 2DX, W Midlands, England,Univ Hosp Coventry and Warwickshire NHS Trust, England (author)
  • Tsolakis, Apostolos V.Karolinska Institutet,Uppsala universitet,Endokrin tumörbiologi,Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden;Karolinska Univ Hosp Solna, CCK, R8 04, Stockholm, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp Solna, Sweden; Uppsala Univ, Sweden(Swepub:uu)aptso227 (author)
  • Kaltsas, GregoryUniv Athens, Laiko Hosp, Dept Propauped Internal Med 1, Oncol Unit, Athens, Greece (author)
  • Uppsala universitetEndokrinkirurgi (creator_code:org_t)

Related titles

  • In:Endocrine: SPRINGER64:2, s. 384-3921355-008X1559-0100

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  • Endocrine (Search for host publication in LIBRIS)

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