Sökning: id:"swepub:oai:DiVA.org:uu-387208" >
Cardiovascular Effe...
-
Nielsen, RoniAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ Hosp, Dept Endocrinol & Metab, Aarhus, Denmark
(författare)
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
-
LIPPINCOTT WILLIAMS & WILKINS,2019
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-387208
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-387208URI
-
https://doi.org/10.1161/CIRCULATIONAHA.118.036459DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
BACKGROUND: Myocardial utilization of 3-hydroxybutyrate (3-OHB) is increased in patients with heart failure and reduced ejection fraction (HFrEF). However, the cardiovascular effects of increased circulating plasma-3-OHB levels in these patients are unknown. Consequently, the authors' aim was to modulate circulating 3-OHB levels in HFrEF patients and evaluate: (1) changes in cardiac output (CO); (2) a potential doseresponse relationship between 3-OHB levels and CO; (3) the impact on myocardial external energy efficiency (MEE) and oxygen consumption (MVO 2); and (4) whether the cardiovascular response differed between HFrEF patients and age-matched volunteers.METHODS: Study 1: 16 chronic HFrEF patients (left ventricular ejection fraction: 37 +/- 3%) were randomized in a crossover design to 3-hour of 3-OHB or placebo infusion. Patients were monitored invasively with a Swan-Ganz catheter and with echocardiography. Study 2: In a doseresponse study, 8 HFrEF patients were examined at increasing 3-OHB infusion rates. Study 3 to 4: 10 HFrEF patients and 10 age-matched volunteers were randomized in a crossover design to 3-hour 3-OHB or placebo infusion. MEE and MVO 2 were evaluated using 11C-acetate positron emission tomography.RESULTS: 3-OHB infusion increased circulating levels of plasma 3-OHB from 0.4 +/- 0.3 to 3.3 +/- 0.4 mM (P< 0.001). CO rose by 2.0 +/- 0.2 L/min (P< 0.001) because of an increase in stroke volume of 20 +/- 2 mL (P< 0.001) and heart rate of 7 +/- 2 beats per minute (bpm) (P< 0.001). Left ventricular ejection fraction increased 8 +/- 1% (P< 0.001) numerically. There was a dose-response relationship with a significant CO increase of 0.3 L/min already at plasma-3-OHB levels of 0.7 mM (P< 0.001). 3-OHB increased MVO 2 without altering MEE. The response to 3-OHB infusion in terms of MEE and CO did not differ between HFrEF patents and age-matched volunteers.CONCLUSIONS: 3-OHB has beneficial hemodynamic effects in HFrEF patients without impairing MEE. These beneficial effects are detectable in the physiological concentration range of circulating 3-OHB levels. The hemodynamic effects of 3-OHB were observed in both HFrEF patients and age-matched volunteers. 3-OHB may potentially constitute a novel treatment principle in HFrEF patients.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Møller, NielsAarhus Univ Hosp, Dept Endocrinol & Metab, Aarhus, Denmark;Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark
(författare)
-
Gormsen, Lars C.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark;Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark
(författare)
-
Tolbod, Lars PoulsenAarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
(författare)
-
Hansson, Nils HenrikAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
(författare)
-
Sörensen, JensUppsala universitet,Radiologi,Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark(Swepub:uu)jenssore
(författare)
-
Harms, Hendrik JohannesAarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
(författare)
-
Frøkiaer, JørgenAarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
(författare)
-
Eiskjaer, HansAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
(författare)
-
Jespersen, Nichlas RiiseAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark
(författare)
-
Mellemkjaer, SorenAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
(författare)
-
Lassen, Thomas RavnAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark
(författare)
-
Pryds, KasperAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark
(författare)
-
Bøtker, Hans ErikAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark
(författare)
-
Wiggers, HenrikAarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark
(författare)
-
Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ Hosp, Dept Endocrinol & Metab, Aarhus, DenmarkAarhus Univ Hosp, Dept Endocrinol & Metab, Aarhus, Denmark;Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Circulation: LIPPINCOTT WILLIAMS & WILKINS139:18, s. 2129-21410009-73221524-4539
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Nielsen, Roni
-
Møller, Niels
-
Gormsen, Lars C.
-
Tolbod, Lars Pou ...
-
Hansson, Nils He ...
-
Sörensen, Jens
-
visa fler...
-
Harms, Hendrik J ...
-
Frøkiaer, Jørgen
-
Eiskjaer, Hans
-
Jespersen, Nichl ...
-
Mellemkjaer, Sor ...
-
Lassen, Thomas R ...
-
Pryds, Kasper
-
Bøtker, Hans Eri ...
-
Wiggers, Henrik
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Circulation
- Av lärosätet
-
Uppsala universitet