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Dietary Nitrate Red...
Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II-Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity
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- Guimaraes, Drielle D. (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden;Univ Fed Paraiba, Ctr Biotechnol, Joao Pessoa, Paraiba, Brazil
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- Cruz, Josiane C. (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden;Univ Fed Paraiba, Ctr Biotechnol, Joao Pessoa, Paraiba, Brazil
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- Carvalho-Galvao, Alynne (författare)
- Univ Fed Paraiba, Ctr Biotechnol, Joao Pessoa, Paraiba, Brazil
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- Zhuge, Zhengbing (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Marques, Stefanne M. (författare)
- Univ Fed Goias, Dept Physiol Sci, Goiania, Go, Brazil
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- Naves, Lara M. (författare)
- Univ Fed Goias, Dept Physiol Sci, Goiania, Go, Brazil
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- Persson, Erik (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Weitzberg, Eddie (författare)
- Karolinska Institutet
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- Lundberg, Jon O. (författare)
- Karolinska Institutet
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- Balarini, Camille M. (författare)
- Univ Fed Paraiba, Ctr Biotechnol, Joao Pessoa, Paraiba, Brazil;Univ Fed Paraiba, Hlth Sci Ctr, Joao Pessoa, Paraiba, Brazil
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- Pedrino, Gustavo R. (författare)
- Univ Fed Goias, Dept Physiol Sci, Goiania, Go, Brazil
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- Braga, Valdir A. (författare)
- Univ Fed Paraiba, Ctr Biotechnol, Joao Pessoa, Paraiba, Brazil
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- Carlstrom, Mattias (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2019
- 2019
- Engelska.
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Ingår i: Hypertension. - : Lippincott Williams & Wilkins. - 0194-911X .- 1524-4563. ; 73:4, s. 839-848
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Several experimental and clinical studies have shown that dietary nitrate supplementation can increase nitric oxide bioavailability. In the oral cavity, commensal bacteria reduce nitrate to nitrite, which is subsequently absorbed into the circulation where reduction to nitric oxide by enzymatic systems occur. Although it is well-known that boosting the nitrate-nitrite-nitric oxide pathway can improve cardiovascular, renal, and metabolic functions and that sympathoexcitation contributes to the development of the same disorders, the potential effects of dietary nitrate on sympathetic activity remain to be elucidated. In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension. Multiple in vivo approaches were combined, that is, Wistar rats orally treated with the nitric oxide synthase inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester, 0.5 g/L) and implanted with subcutaneous osmotic minipump for continuous delivery of Ang II (120 ng/kg per minute; 14 days). Simultaneously, rats were supplemented with sodium nitrate (10 mmol/L) or placebo (sodium chloride; 10 mmol/L) in the drinking water. Blood pressure, heart rate, and renal sympathetic nerve activity were recorded. In placebo-treated rats, Ang II+ L-NAME treatment-induced arterial hypertension, which was linked with reduced spontaneous baroreflex sensitivity and increased renal sympathetic nerve activity, as well as upregulation of AT 1 Rs (Ang II type-1 receptors) in the rostral ventrolateral medulla. Supplementation with nitrate normalized the expression of AT 1 Rs in rostral ventrolateral medulla and reduced sympathetic nerve activity, which was associated with attenuated development of hypertension. In conclusion, chronic dietary nitrate supplementation blunted the development of hypertension via mechanisms that involve reduction of sympathetic outflow.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- angiotensin II
- blood pressure
- hypertension
- kidney
- nitric oxide
- sodium nitrate
- sympathethic activity
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Guimaraes, Driel ...
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Cruz, Josiane C.
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Carvalho-Galvao, ...
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Zhuge, Zhengbing
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Marques, Stefann ...
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Naves, Lara M.
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visa fler...
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Persson, Erik
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Weitzberg, Eddie
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Lundberg, Jon O.
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Balarini, Camill ...
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Pedrino, Gustavo ...
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Braga, Valdir A.
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Carlstrom, Matti ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Fysiologi
- Artiklar i publikationen
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Hypertension
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Uppsala universitet
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Karolinska Institutet