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Biomarkers of Dieta...
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Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia,Natl Inst Publ Hlth & Environm, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands,Florida Int Univ, Herbert Wertheim Coll Med, Benjamin Leon Geriatr Res & Educ, Miami, FL 33199 USA,Wageningen Univ, Div Human Nutr, Wageningen, Netherlands,Univ Washington, Dept Med, Cardiovasc Hlth Study, Seattle, WA USA;Univ Washington, Dept Epidemiol, Cardiovasc Hlth Study, Seattle, WA 98195 USA;Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Study, Seattle, WA 98195 USA;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA,Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
(author)
Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality : An Individual-Level Pooled Analysis of 30 Cohort Studies
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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American Heart Association,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-387592
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-387592URI
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https://doi.org/10.1161/CIRCULATIONAHA.118.038908DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158789URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background:Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies.Methods:We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease, ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytic plan. Levels of LA and AA, measured as the percentage of total fatty acids, were evaluated linearly according to their interquintile range (ie, the range between the midpoint of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes mellitus, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available).Results:In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15198 incident cardiovascular events occurred among 68659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88-0.99), 0.78 (0.70-0.85), and 0.88 (0.79-0.98), respectively, and nonsignificantly with lower coronary heart disease risk (0.94; 0.88-1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86-0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships.Conclusions:In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wu, Jason H. Y.Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia,Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Fukuoka, Japan
(author)
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Imamura, FumiakiUniv Cambridge, MRC, Epidemiol Unit, Cambridge, England
(author)
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Del Gobbo, Liana C.Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA
(author)
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Fretts, AmandaUniv Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
(author)
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de Goede, JanetteWageningen Univ, Div Human Nutr, Wageningen, Netherlands
(author)
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Shi, PeilinTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
(author)
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Tintle, NathanDordt Coll, Dept Math & Stat, Sioux Ctr, IA USA
(author)
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Wennberg, Maria,1974-Umeå universitet,Näringsforskning,Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Umea, Sweden(Swepub:umu)mawe0024
(author)
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Aslibekyan, StellaUniv Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA
(author)
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Chen, Tzu-AnBaylor Coll Med, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA
(author)
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Otto, Marcia C. de OliveiraUniv Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA
(author)
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Hirakawa, YoichiroKyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Fukuoka, Japan
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Eriksen, Helle HojmarkAalborg Univ Hosp, Unit Epidemiol & Biostat, Aalborg, Denmark
(author)
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Kroeger, JanineGerman Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany
(author)
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Laguzzi, FedericaKarolinska Inst, Unit Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden
(author)
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Lankinen, MariaUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
(author)
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Murphy, Rachel A.Univ British Columbia, Vancouver, BC, Canada
(author)
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Prem, KieshaNatl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
(author)
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Samieri, CeciliaUniv Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, TUMR 1219, Bordeaux, France
(author)
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Virtanen, JyrkiUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
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Wood, Alexis C.Baylor Coll Med, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA
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Wong, KerryUniv Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
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Yang, Wei-SinNatl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan
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Zhou, XiaUniv Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
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Baylin, AnaUniv Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USA;Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
(author)
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Boer, Jolanda M. A.Natl Inst Publ Hlth & Environm, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands
(author)
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Brouwer, Ingeborg A.Vrije Univ, Hlth Sci, Amsterdam, Netherlands
(author)
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Campos, HanniaHarvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
(author)
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Chaves, Paulo H. M.Florida Int Univ, Herbert Wertheim Coll Med, Benjamin Leon Geriatr Res & Educ, Miami, FL 33199 USA
(author)
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Chien, Kuo-LiongNatl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan;Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
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de Faire, UlfKarolinska Inst, Unit Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden
(author)
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Djousse, LucBrigham & Womens Hosp, Boston Vet Affairs Healthcare Syst, Boston, MA 02115 USA
(author)
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Eiriksdottir, GudnyIceland Heart Assoc, Kopavogur, Iceland
(author)
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El-Abbadi, NaglaaTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA;USDA, Jean Mayer Human Nutr Res Ctr, Boston, MA USA
(author)
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Forouhi, Nita G.Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England,Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
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Gaziano, J. MichaelBrigham & Womens Hosp, Boston Vet Affairs Healthcare Syst, Boston, MA 02115 USA
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Geleijnse, Johanna M.Wageningen Univ, Div Human Nutr, Wageningen, Netherlands
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Gigante, BrunaKarolinska Inst, Unit Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden
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Giles, GrahamUniv Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
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Guallar, EliseoJohns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Div Environm Epidemiol, Baltimore, MD USA
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Gudnason, VilmundurIceland Heart Assoc, Kopavogur, Iceland
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Harris, TamaraNIA, Bethesda, MD 20892 USA
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Harris, William S.Univ South Dakota, Dept Internal Med, Sanford Sch Med, Sioux Falls, SD USA;OmegaQuant Analyt LLC, Sioux Falls, SD USA
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Helmer, CatherineUniv Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, TUMR 1219, Bordeaux, France
(author)
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Hellenius, Mai-LisKarolinska Univ Hosp, Karolinska Inst, Cardiol Unit, Dept Med, Stockholm, Sweden
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Hodge, AllisonUniv Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
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Hu, Frank B.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
(author)
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Jacques, Paul F.Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA;USDA, Jean Mayer Human Nutr Res Ctr, Boston, MA USA
(author)
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Jansson, Jan-HåkanUmeå universitet,Avdelningen för medicin,Research Unit Skellefteå, Umeå University, Umeå, Sweden.,Umea Univ, Dept Publ Hlth & Clin Med, Res Unit Skelleftea, Umea, Sweden(Swepub:umu)jaja0006
(author)
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Kalsbeek, AnyaDordt Coll, Dept Math & Stat, Sioux Ctr, IA USA
(author)
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Khaw, Kay-TeeUniv Cambridge, Dept Publ Hlth & Primary Care, Sch Clin Med, Cambridge, England
(author)
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Koh, Woon-PuayNatl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Duke NUS Med Sch, Singapore, Singapore
(author)
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Laakso, MarkkuUniv Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland
(author)
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Leander, KarinKarolinska Inst, Unit Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden
(author)
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Lin, Hung-JuNatl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
(author)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
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Luben, RobertUniv Cambridge, Dept Publ Hlth & Primary Care, Sch Clin Med, Cambridge, England
(author)
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Luo, JuhuaIndiana Univ, Dept Epidemiol & Biostat, Bloomington, IN USA
(author)
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McKnight, BarbaraUniv Washington, Dept Biostat, Sch Publ Hlth, Seattle, WA 98195 USA
(author)
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Mursu, JaakkoUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
(author)
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Ninomiya, ToshiharuKyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Fukuoka, Japan
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Overvad, KimAarhus Univ, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark;Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark
(author)
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Psaty, Bruce M.Univ Washington, Dept Med, Cardiovasc Hlth Study, Seattle, WA USA;Univ Washington, Dept Epidemiol, Cardiovasc Hlth Study, Seattle, WA 98195 USA;Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Study, Seattle, WA 98195 USA;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA
(author)
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Rimm, EricHarvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
(author)
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Schulze, Matthias B.German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany
(author)
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Siscovick, DavidNew York Acad Med, New York, NY USA
(author)
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Nielsen, Michael SkjelboAalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark
(author)
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Smith, Albert, VIceland Heart Assoc, Kopavogur, Iceland
(author)
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Steffen, Brian T.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
(author)
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Steffen, LynUniv Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
(author)
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Sun, QiHarvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
(author)
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Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi(Swepub:uu)johasund
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Tsai, Michael Y.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
(author)
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Tunstall-Pedoe, HughUniv Dundee, Cardiovasc Epidemiol Unit, Inst Cardiovasc Res, Dundee, Scotland
(author)
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Uusitupa, Matti I. J.Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
(author)
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van Dam, Rob M.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
(author)
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Veenstra, JennaDordt Coll, Dept Math & Stat, Sioux Ctr, IA USA
(author)
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Verschuren, W. M. MoniqueNatl Inst Publ Hlth & Environm, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands,Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia;Univ Dundee, Cardiovasc Epidemiol Unit, Inst Cardiovasc Res, Dundee, Scotland;Univ Oxford, George Inst Global Hlth, Oxford, England
(author)
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Wareham, NickUniv Cambridge, MRC, Epidemiol Unit, Cambridge, England
(author)
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Willett, WalterHarvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
(author)
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Woodward, MarkUniv New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia;Univ Dundee, Cardiovasc Epidemiol Unit, Inst Cardiovasc Res, Dundee, Scotland;Univ Oxford, George Inst Global Hlth, Oxford, England
(author)
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Yuan, Jian-MinUniv Pittsburgh, Div Canc Control & Populat Sci, UPMC Hillman Canc, Pittsburgh, PA 15260 USA;Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA
(author)
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Micha, RenataTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
(author)
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Lemaitre, Rozenn N.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
(author)
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Mozaffarian, DariushTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
(author)
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Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser
(author)
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Wareham, Nicholas
(author)
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Uppsala universitetKlinisk nutrition och metabolism
(creator_code:org_t)
Related titles
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In:Circulation: American Heart Association139:21, s. 2422-24360009-73221524-4539
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Marklund, Matti
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Wu, Jason H. Y.
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Imamura, Fumiaki
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Del Gobbo, Liana ...
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Fretts, Amanda
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de Goede, Janett ...
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Shi, Peilin
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Tintle, Nathan
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Wennberg, Maria, ...
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Chen, Tzu-An
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Otto, Marcia C. ...
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Hirakawa, Yoichi ...
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Eriksen, Helle H ...
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Kroeger, Janine
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Laguzzi, Federic ...
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Lankinen, Maria
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Murphy, Rachel A ...
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Prem, Kiesha
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Samieri, Cecilia
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Virtanen, Jyrki
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Wood, Alexis C.
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Wong, Kerry
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Yang, Wei-Sin
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Zhou, Xia
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Baylin, Ana
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Boer, Jolanda M. ...
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Brouwer, Ingebor ...
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Campos, Hannia
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Chaves, Paulo H. ...
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Chien, Kuo-Liong
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de Faire, Ulf
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Djousse, Luc
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Eiriksdottir, Gu ...
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El-Abbadi, Nagla ...
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Forouhi, Nita G.
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Gaziano, J. Mich ...
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Geleijnse, Johan ...
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Gigante, Bruna
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Giles, Graham
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Guallar, Eliseo
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Gudnason, Vilmun ...
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Harris, Tamara
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Harris, William ...
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Helmer, Catherin ...
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Hellenius, Mai-L ...
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Hodge, Allison
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Hu, Frank B.
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Jacques, Paul F.
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Jansson, Jan-Håk ...
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Kalsbeek, Anya
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Khaw, Kay-Tee
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Koh, Woon-Puay
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Laakso, Markku
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Leander, Karin
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Lin, Hung-Ju
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Lind, Lars
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Luben, Robert
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Luo, Juhua
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McKnight, Barbar ...
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Mursu, Jaakko
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Ninomiya, Toshih ...
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Overvad, Kim
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Psaty, Bruce M.
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Rimm, Eric
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Schulze, Matthia ...
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Siscovick, David
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Nielsen, Michael ...
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Smith, Albert, V
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Steffen, Brian T ...
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Steffen, Lyn
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Sun, Qi
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Sundström, Johan ...
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Tsai, Michael Y.
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Tunstall-Pedoe, ...
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Uusitupa, Matti ...
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van Dam, Rob M.
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Veenstra, Jenna
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Verschuren, W. M ...
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Wareham, Nick
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Willett, Walter
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Woodward, Mark
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Yuan, Jian-Min
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Micha, Renata
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Lemaitre, Rozenn ...
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Risérus, Ulf, 19 ...
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