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Biomarkers of Dieta...
Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality : An Individual-Level Pooled Analysis of 30 Cohort Studies
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- Marklund, Matti (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia,Natl Inst Publ Hlth & Environm, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands,Florida Int Univ, Herbert Wertheim Coll Med, Benjamin Leon Geriatr Res & Educ, Miami, FL 33199 USA,Wageningen Univ, Div Human Nutr, Wageningen, Netherlands,Univ Washington, Dept Med, Cardiovasc Hlth Study, Seattle, WA USA;Univ Washington, Dept Epidemiol, Cardiovasc Hlth Study, Seattle, WA 98195 USA;Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Study, Seattle, WA 98195 USA;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA,Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
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- Wu, Jason H. Y. (författare)
- Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia,Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Fukuoka, Japan
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- Imamura, Fumiaki (författare)
- Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England
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visa fler...
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- Del Gobbo, Liana C. (författare)
- Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA
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- Fretts, Amanda (författare)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
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- de Goede, Janette (författare)
- Wageningen Univ, Div Human Nutr, Wageningen, Netherlands
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- Shi, Peilin (författare)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
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- Tintle, Nathan (författare)
- Dordt Coll, Dept Math & Stat, Sioux Ctr, IA USA
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- Wennberg, Maria, 1974- (författare)
- Umeå universitet,Näringsforskning,Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Umea, Sweden
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- Aslibekyan, Stella (författare)
- Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA
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- Chen, Tzu-An (författare)
- Baylor Coll Med, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA
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- Otto, Marcia C. de Oliveira (författare)
- Univ Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA
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- Hirakawa, Yoichiro (författare)
- Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Fukuoka, Japan
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- Eriksen, Helle Hojmark (författare)
- Aalborg Univ Hosp, Unit Epidemiol & Biostat, Aalborg, Denmark
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- Kroeger, Janine (författare)
- German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany
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- Laguzzi, Federica (författare)
- Karolinska Inst, Unit Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden
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- Lankinen, Maria (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
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- Murphy, Rachel A. (författare)
- Univ British Columbia, Vancouver, BC, Canada
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- Prem, Kiesha (författare)
- Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
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- Samieri, Cecilia (författare)
- Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, TUMR 1219, Bordeaux, France
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- Virtanen, Jyrki (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
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- Wood, Alexis C. (författare)
- Baylor Coll Med, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA
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- Wong, Kerry (författare)
- Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
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- Yang, Wei-Sin (författare)
- Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan
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- Zhou, Xia (författare)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
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- Baylin, Ana (författare)
- Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USA;Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
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- Boer, Jolanda M. A. (författare)
- Natl Inst Publ Hlth & Environm, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands
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- Brouwer, Ingeborg A. (författare)
- Vrije Univ, Hlth Sci, Amsterdam, Netherlands
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- Campos, Hannia (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
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- Chaves, Paulo H. M. (författare)
- Florida Int Univ, Herbert Wertheim Coll Med, Benjamin Leon Geriatr Res & Educ, Miami, FL 33199 USA
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- Chien, Kuo-Liong (författare)
- Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan;Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
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- de Faire, Ulf (författare)
- Karolinska Inst, Unit Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden
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- Djousse, Luc (författare)
- Brigham & Womens Hosp, Boston Vet Affairs Healthcare Syst, Boston, MA 02115 USA
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- Eiriksdottir, Gudny (författare)
- Iceland Heart Assoc, Kopavogur, Iceland
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- El-Abbadi, Naglaa (författare)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA;USDA, Jean Mayer Human Nutr Res Ctr, Boston, MA USA
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- Forouhi, Nita G. (författare)
- Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England,Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
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- Gaziano, J. Michael (författare)
- Brigham & Womens Hosp, Boston Vet Affairs Healthcare Syst, Boston, MA 02115 USA
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- Geleijnse, Johanna M. (författare)
- Wageningen Univ, Div Human Nutr, Wageningen, Netherlands
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- Gigante, Bruna (författare)
- Karolinska Inst, Unit Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden
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- Giles, Graham (författare)
- Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
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- Guallar, Eliseo (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Div Environm Epidemiol, Baltimore, MD USA
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- Gudnason, Vilmundur (författare)
- Iceland Heart Assoc, Kopavogur, Iceland
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- Harris, Tamara (författare)
- NIA, Bethesda, MD 20892 USA
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- Harris, William S. (författare)
- Univ South Dakota, Dept Internal Med, Sanford Sch Med, Sioux Falls, SD USA;OmegaQuant Analyt LLC, Sioux Falls, SD USA
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- Helmer, Catherine (författare)
- Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, TUMR 1219, Bordeaux, France
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- Hellenius, Mai-Lis (författare)
- Karolinska Univ Hosp, Karolinska Inst, Cardiol Unit, Dept Med, Stockholm, Sweden
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- Hodge, Allison (författare)
- Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
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- Hu, Frank B. (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
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- Jacques, Paul F. (författare)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA;USDA, Jean Mayer Human Nutr Res Ctr, Boston, MA USA
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- Jansson, Jan-Håkan (författare)
- Umeå universitet,Avdelningen för medicin,Research Unit Skellefteå, Umeå University, Umeå, Sweden.,Umea Univ, Dept Publ Hlth & Clin Med, Res Unit Skelleftea, Umea, Sweden
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- Kalsbeek, Anya (författare)
- Dordt Coll, Dept Math & Stat, Sioux Ctr, IA USA
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- Khaw, Kay-Tee (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Sch Clin Med, Cambridge, England
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- Koh, Woon-Puay (författare)
- Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Duke NUS Med Sch, Singapore, Singapore
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- Laakso, Markku (författare)
- Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland
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- Leander, Karin (författare)
- Karolinska Inst, Unit Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden
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- Lin, Hung-Ju (författare)
- Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
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- Lind, Lars (författare)
- Uppsala universitet,Klinisk epidemiologi
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- Luben, Robert (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Sch Clin Med, Cambridge, England
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- Luo, Juhua (författare)
- Indiana Univ, Dept Epidemiol & Biostat, Bloomington, IN USA
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- McKnight, Barbara (författare)
- Univ Washington, Dept Biostat, Sch Publ Hlth, Seattle, WA 98195 USA
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- Mursu, Jaakko (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
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- Ninomiya, Toshiharu (författare)
- Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Fukuoka, Japan
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- Overvad, Kim (författare)
- Aarhus Univ, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark;Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark
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- Psaty, Bruce M. (författare)
- Univ Washington, Dept Med, Cardiovasc Hlth Study, Seattle, WA USA;Univ Washington, Dept Epidemiol, Cardiovasc Hlth Study, Seattle, WA 98195 USA;Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Study, Seattle, WA 98195 USA;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA
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- Rimm, Eric (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
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- Schulze, Matthias B. (författare)
- German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany
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- Siscovick, David (författare)
- New York Acad Med, New York, NY USA
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- Nielsen, Michael Skjelbo (författare)
- Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark
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- Smith, Albert, V (författare)
- Iceland Heart Assoc, Kopavogur, Iceland
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- Steffen, Brian T. (författare)
- Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
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- Steffen, Lyn (författare)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
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- Sun, Qi (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
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- Sundström, Johan, Professor, 1971- (författare)
- Uppsala universitet,Klinisk epidemiologi
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- Tsai, Michael Y. (författare)
- Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
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- Tunstall-Pedoe, Hugh (författare)
- Univ Dundee, Cardiovasc Epidemiol Unit, Inst Cardiovasc Res, Dundee, Scotland
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- Uusitupa, Matti I. J. (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
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- van Dam, Rob M. (författare)
- Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
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- Veenstra, Jenna (författare)
- Dordt Coll, Dept Math & Stat, Sioux Ctr, IA USA
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- Verschuren, W. M. Monique (författare)
- Natl Inst Publ Hlth & Environm, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands,Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia;Univ Dundee, Cardiovasc Epidemiol Unit, Inst Cardiovasc Res, Dundee, Scotland;Univ Oxford, George Inst Global Hlth, Oxford, England
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- Wareham, Nick (författare)
- Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England
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- Willett, Walter (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
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- Woodward, Mark (författare)
- Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia;Univ Dundee, Cardiovasc Epidemiol Unit, Inst Cardiovasc Res, Dundee, Scotland;Univ Oxford, George Inst Global Hlth, Oxford, England
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- Yuan, Jian-Min (författare)
- Univ Pittsburgh, Div Canc Control & Populat Sci, UPMC Hillman Canc, Pittsburgh, PA 15260 USA;Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA
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- Micha, Renata (författare)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
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- Lemaitre, Rozenn N. (författare)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
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- Mozaffarian, Dariush (författare)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
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- Risérus, Ulf, 1967- (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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Wareham, Nicholas (författare)
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(creator_code:org_t)
- American Heart Association, 2019
- 2019
- Engelska.
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Ingår i: Circulation. - : American Heart Association. - 0009-7322 .- 1524-4539. ; 139:21, s. 2422-2436
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background:Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies.Methods:We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease, ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytic plan. Levels of LA and AA, measured as the percentage of total fatty acids, were evaluated linearly according to their interquintile range (ie, the range between the midpoint of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes mellitus, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available).Results:In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15198 incident cardiovascular events occurred among 68659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88-0.99), 0.78 (0.70-0.85), and 0.88 (0.79-0.98), respectively, and nonsignificantly with lower coronary heart disease risk (0.94; 0.88-1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86-0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships.Conclusions:In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- arachidonic acid
- biomarkers
- cardiovascular diseases
- diet
- epidemiology
- linoleic acid
- primary prevention
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- Av författaren/redakt...
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Marklund, Matti
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Wu, Jason H. Y.
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Imamura, Fumiaki
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Del Gobbo, Liana ...
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Fretts, Amanda
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de Goede, Janett ...
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visa fler...
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Shi, Peilin
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Tintle, Nathan
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Wennberg, Maria, ...
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Aslibekyan, Stel ...
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Chen, Tzu-An
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Otto, Marcia C. ...
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Hirakawa, Yoichi ...
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Eriksen, Helle H ...
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Kroeger, Janine
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Laguzzi, Federic ...
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Lankinen, Maria
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Murphy, Rachel A ...
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Prem, Kiesha
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Samieri, Cecilia
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Virtanen, Jyrki
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Wood, Alexis C.
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Wong, Kerry
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Yang, Wei-Sin
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Zhou, Xia
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Baylin, Ana
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Boer, Jolanda M. ...
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Brouwer, Ingebor ...
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Campos, Hannia
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Chaves, Paulo H. ...
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Chien, Kuo-Liong
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de Faire, Ulf
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Djousse, Luc
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Eiriksdottir, Gu ...
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El-Abbadi, Nagla ...
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Forouhi, Nita G.
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Gaziano, J. Mich ...
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Geleijnse, Johan ...
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Gigante, Bruna
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Giles, Graham
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Guallar, Eliseo
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Gudnason, Vilmun ...
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Harris, Tamara
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Harris, William ...
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Helmer, Catherin ...
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Hellenius, Mai-L ...
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Hodge, Allison
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Hu, Frank B.
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Jacques, Paul F.
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Jansson, Jan-Håk ...
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Kalsbeek, Anya
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Khaw, Kay-Tee
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Koh, Woon-Puay
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Laakso, Markku
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Leander, Karin
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Lin, Hung-Ju
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Lind, Lars
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Luben, Robert
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Luo, Juhua
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McKnight, Barbar ...
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Mursu, Jaakko
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Ninomiya, Toshih ...
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Overvad, Kim
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Psaty, Bruce M.
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Rimm, Eric
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Schulze, Matthia ...
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Siscovick, David
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Nielsen, Michael ...
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Smith, Albert, V
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Steffen, Brian T ...
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Steffen, Lyn
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Sun, Qi
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Sundström, Johan ...
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Tsai, Michael Y.
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Tunstall-Pedoe, ...
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Uusitupa, Matti ...
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van Dam, Rob M.
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Veenstra, Jenna
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Verschuren, W. M ...
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Wareham, Nick
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Willett, Walter
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Woodward, Mark
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Yuan, Jian-Min
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Micha, Renata
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Lemaitre, Rozenn ...
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Mozaffarian, Dar ...
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Risérus, Ulf, 19 ...
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Wareham, Nichola ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Circulation
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Uppsala universitet
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