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Thirteen weeks of s...
Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults : the PROVIDE study
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- Liberman, Keliane (author)
- VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium
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- Njemini, Rose (author)
- VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium
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- Luiking, Yvette (author)
- Nutricia Res, Nutricia Adv Med Nutr, Utrecht, Netherlands
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- Forti, Louis N. (author)
- VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium
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- Verlaan, Sjors (author)
- Vrije Univ Amsterdam, Med Ctr, Sect Gerontol & Geriatr, Dept Internal Med, Amsterdam, Netherlands
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- Bauer, Juergen M. (author)
- Heidelberg Univ, Ctr Geriatr Med, Heidelberg, Germany
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- Memelink, Robert (author)
- VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium;Amsterdam Univ Appl Sci, Fac Sports & Nutr, Amsterdam, Netherlands
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- Brandt, Kirsten (author)
- Newcastle Univ, Inst Cellular Med, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
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- Donini, Lorenzo M. (author)
- Sapienza Univ Rome, Sect Med Pathophysiol Endocrinol & Human Nutr, Dept Expt Med, Rome, Italy
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- Maggio, Marcello (author)
- Univ Parma, Sect Geriatr, Dept Med & Surg, Parma, Italy
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- Mets, Tony (author)
- VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium
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- Wijers, Sander L. J. (author)
- Nutricia Res, Nutricia Adv Med Nutr, Utrecht, Netherlands
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- Sieber, Cornel (author)
- Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany
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- Cederholm, Tommy (author)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Geriatrik
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- Bautmans, Ivan (author)
- VUB, Frailty Ageing Res Grp FRIA, Laarbeeklaan 103, B-1090 Brussels, Belgium
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(creator_code:org_t)
- 2019-05-02
- 2019
- English.
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In: Aging Clinical and Experimental Research. - : SPRINGER. - 1594-0667 .- 1720-8319. ; 31:6, s. 845-854
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Abstract
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- Background A chronic low-grade infammatory profle (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for efects of nutritional supplementation on CLIP is limited. Aim To investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein afected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis. Methods Sarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4–9) and a body mass index of 20–30 kg/m2 were randomly allocated to two daily servings of active (n=137, including 20 g of whey protein, 3 g of leucine and 800 IU VitD) or isocaloric control product (n=151) for a double-blind period of 13 weeks. At baseline and after 13 weeks, circulating interleukin (IL)-8, IL-1 receptor antagonist (RA), soluble tumor-necrosis-factor receptor (sTNFR)1, IL-6, high-sensitivity C-reactive protein, pre-albumin and 25-hydroxyvitamin(OH) D were measured. Data-analysis included repeated measures analysis of covariance (corrected for dietary VitD intake) and linear regression. Results IL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p=0.006 and p<0.001, respectively). For IL-6 a signifcant time × treatment interaction (p=0.046) was observed, with no signifcant change over time in the active group (p=0.155) compared to control (signifcant increase p=0.012). IL-8 showed an overall signifcant decrease (p=0.03). The change in pre-albumin was a signifcant predictor for changes in IL-6 after 13 weeks. Conclusions We conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- Vitamin D
- Leucine
- Whey proteins
- Dietary supplements
- Cytokines
- Aged
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Liberman, Kelian ...
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Njemini, Rose
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Luiking, Yvette
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Forti, Louis N.
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Verlaan, Sjors
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Bauer, Juergen M ...
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show more...
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Memelink, Robert
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Brandt, Kirsten
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Donini, Lorenzo ...
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Maggio, Marcello
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Mets, Tony
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Wijers, Sander L ...
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Sieber, Cornel
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Cederholm, Tommy
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Bautmans, Ivan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
- Articles in the publication
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Aging Clinical a ...
- By the university
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Uppsala University
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Karolinska Institutet