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Sökning: WFRF:(AlAjmi Mohamed F.) > Biogenesis of ZnO n...

Biogenesis of ZnO nanoparticles using Pandanus odorifer leaf extract : anticancer and antimicrobial activities

Hussain, Afzal (författare)
King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia
Oves, Mohammad (författare)
King Abdulaziz Univ, Ctr Excellence Environm Studies, Jeddah 21589, Saudi Arabia
Alajmi, Mohamed F. (författare)
King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia
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Hussain, Iqbal (författare)
Jubail Ind Coll, Dept Gen Studies, Jubail Ind City 31961, Jubail, Saudi Arabia
Amir, Samira (författare)
Alfaisal Univ, Dept Chem, Coll Sci & Gen Studies, Riyadh 11451, Saudi Arabia
Ahmed, Jahangeer (författare)
King Saud Univ, Dept Chem, Coll Sci, Riyadh 11451, Saudi Arabia
Rehman, Md Tabish (författare)
King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia
El-Seedi, Hesham (författare)
Uppsala universitet,Farmakognosi
Ali, Imran (författare)
Taibah Univ, Dept Chem, Coll Sci, Al Medina Al Munawara 41477, Saudi Arabia;Jamia Millia Islamia, Dept Chem, New Delhi, India
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 (creator_code:org_t)
2019
2019
Engelska.
Ingår i: RSC Advances. - : ROYAL SOC CHEMISTRY. - 2046-2069. ; 9:27, s. 15357-15369
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The continuously increasing incidence rates of cancer and infectious diseases are open threats to the sustainable survival of animals and humans. In the last two decades, the demands of nanomaterials as modern therapeutic agents have increased. In this study, biogenic zinc oxide nanoparticles (ZnO NPs) were developed from aqueous Pandanus odorifer leaf extract (POLE) and characterized using modern methods and tools, such as electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy and UV-vis spectroscopy, which indicated the formation of very pure, spherical NPs approximately 90 nm in size. The anticancer activity of the ZnO NPs was evaluated by MTT and neutral red uptake (NRU) assays in MCF-7, HepG2 and A-549 cells at different doses (1, 2, 5, 10, 25, 50, 100 g ml(-1)). Moreover, the morphology of the treated cancer cells was examined by phase contrast microscopy. The results suggest that the synthesized ZnO NPs inhibited the growth of the cells when applied a concentration from 50-100 g ml(-1). Moreover, the biogenic ZnO NPs were analysed as an antimicrobial agent against pathogenic bacteria. The highest antibacterial activity was observed against Gram-positive Bacillus subtilis (26 nm) and Gram-negative Escherichia coli (24 mm) at 50 g per well. Complete bacterial growth (100%) vanished 100% upon treatment with ZnO NPs at 85 g ml(-1). Overall, POLE mediated derived biogenic ZnO NPs could serve as a significant anticancer and antimicrobial agent and be used in the development of novel drugs and skin care products.

Ämnesord

NATURVETENSKAP  -- Kemi -- Annan kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)

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