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Prevalence of and R...
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Mwaiswelo, Richard
(författare)
Prevalence of and Risk Factors Associated with Polymerase Chain Reaction-Determined Plasmodium falciparum Positivity on Day 3 after Initiation of Artemether-Lumefantrine Treatment for Uncomplicated Malaria in Bagamoyo District, Tanzania
- Artikel/kapitelEngelska2019
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American Society of Tropical Medicine and Hygiene,2019
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-389947
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-389947URI
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https://doi.org/10.4269/ajtmh.18-0729DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141393620URI
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https://res.slu.se/id/publ/99582URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Prevalence of and risk factors associated with polymerase chain reaction (PCR)-determined Plasmodium falciparum positivity were assessed on day 3 after initiation of treatment, pre-implementation and up to 8 years post-deployment of artemether-lumefantrine as first-line treatment for uncomplicated malaria in Bagamoyo district, Tanzania. Samples originated from previously reported trials conducted between 2006 and 2014. Cytochrome b-nested PCR was used to detect malaria parasites from blood samples collected on a filter paper on day 3. Chi-square and McNemar chi-squared tests, logistic regression models, and analysis of variance were used as appropriate. Primary outcome was based on the proportion of patients with day 3 PCR-determined P. falciparum positivity. Overall, 256/584 (43.8%) of screened patients had day 3 PCR-determined positivity, whereas only 2/584 (0.3%) had microscopy-determined asexual parasitemia. Day 3 PCR-determined positivity increased from 28.0% (14/50) in 2006 to 74.2% (132/178) in 2007-2008 and declined, thereafter, to 36.0% (50/139) in 2012-2013 and 27.6% (60/217) in 2014. When data were pooled, pretreatment microscopy-determined asexual parasitemia ≥ 100,000/µL, hemoglobin < 10 g/dL, age < 5 years, temperature ≥ 37.5°C, and year of study 2007-2008 and 2012-2013 were significantly associated with PCR-determined positivity on day 3. Significant increases in P. falciparum multidrug resistance gene 1 N86 and P. falciparum chloroquine resistant transporter K76 across years were not associated with PCR-determined positivity on day 3. No statistically significant association was observed between day 3 PCR-determined positivity and PCR-adjusted recrudescence. Day 3 PCR-determined P. falciparum positivity remained common in patients treated before and after implementation of artemether-lumefantrine in Bagamoyo district, Tanzania. However, its presence was associated with pretreatment characteristics. Trials registration numbers: NCT00336375, ISRCTN69189899, NCT01998295, and NCT02090036.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ngasala, BillyUppsala universitet,Internationell barnhälsa och nutrition,Department of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania(Swepub:uu)bilng827
(författare)
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Jovel, Irina
(författare)
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Xu, Weiping
(författare)
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Larsson, Erik
(författare)
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Malmberg, MajaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Institutionen för husdjursgenetik (HGEN),Department of Biomedical Science and Veterinary Public Health,Department of Animal Breeding and Genetics(Swepub:slu)97433
(författare)
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Gil, Jose PedroKarolinska Institutet,Uppsala universitet,Internationell barnhälsa och nutrition,Drug Resistance Unit, Division of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)jospe411
(författare)
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Premji, Zul
(författare)
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Mmbando, Bruno P.
(författare)
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Mårtensson, Andreas,1963-Uppsala universitet,Internationell barnhälsa och nutrition(Swepub:uu)andma331
(författare)
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Uppsala universitetInternationell barnhälsa och nutrition
(creator_code:org_t)
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Sveriges lantbruksuniversitet
Sammanhörande titlar
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Ingår i:American Journal of Tropical Medicine and Hygiene: American Society of Tropical Medicine and Hygiene100:5, s. 1179-11860002-96371476-1645
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Ngasala, Billy
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Jovel, Irina
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Xu, Weiping
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Larsson, Erik
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Malmberg, Maja
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Gil, Jose Pedro
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