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Sökning: id:"swepub:oai:DiVA.org:uu-389985" > Cell of origin in d...

  • Tessier-Cloutier, BasileUniv British Columbia, Anat Pathol & Lab Med, Vancouver, BC, Canada (författare)

Cell of origin in diffuse large B-cell lymphoma in systemic lupus erythematosus : molecular and clinical factors associated with survival

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-05-04
  • BMJ PUBLISHING GROUP,2019
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-389985
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-389985URI
  • https://doi.org/10.1136/lupus-2019-000324DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background SLE is associated with increased risk of diffuse large B-cell lymphoma (DLBCL). DLBCL is routinely classified by cell of origin (COO), with germinal centre B-cell (GCB) being more common and indicating better prognosis in the general population. We studied COO subtyping in patients with SLE diagnosed with DLBCL and their survival. Patients and methods We evaluated 20 cases of SLE with DLBCL. Immunohistochemistry analysis was performed (BCL2, MYC, BCL6, CD10, CD20, FOXP1, GCET1, MUM1) in tissue microarrays. We examined associations between molecular and clinical features, including overall survival. Results Of the 20 DLBCL SLE cases, 12/20 cases (60%) were classified as non-GCB using Hans or Choi algorithms. MYC and BCL2 protein expression was positive in 6/20 (30%) and 8/20 (40%) SLE cases, respectively, with 2/20 (10%) co-expressing both markers. Seven (7/20) had only extranodal involvement at DLBCL diagnosis. As expected, non-GCB cases had worse survival. Cases presenting exclusively with extranodal disease were associated with shorter SLE duration and better survival despite higher BCL2 protein expression. Conclusions We present novel data characterising DLBCL in SLE. Sixty per cent of the DLBCL in patients with SLE were non-GCB. The nodal and extranodal distribution in SLE was similar to what is known in the general population, but extranodal disease occurred more often with short SLE duration and was associated with longer overall survival. More research on cancer in SLE is the key to further understanding the complex interplay between cancer and the immune system.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Twa, David D. W.Univ British Columbia, Fac Med, Vancouver, BC, Canada (författare)
  • Baecklund, Eva,1956-Uppsala universitet,Reumatologi(Swepub:uu)evaba786 (författare)
  • Gascoyne, RandyUniv British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada;British Columbia Canc Agcy, Pathol Dept, Vancouver, BC, Canada;British Columbia Canc Agcy, Ctr Lymphoid Canc, Vancouver, BC, Canada (författare)
  • Johnson, Nathalie A.Sir Mortimer B Davis Jewish Hosp, Dept Med, Montreal, PQ, Canada (författare)
  • Backlin, CarinMed Univ South Carolina, Dept Rheumatol & Immunol, Charleston, SC 29425 USA (författare)
  • Kamen, Diane L.Med Univ South Carolina, Med, Charleston, SC 29425 USA (författare)
  • Clarke, Ann E.Univ Calgary, Calgary, AB, Canada (författare)
  • Ramsey-Goldman, RosalindNorthwestern Univ, Med Rheumatol, Chicago, IL 60611 USA (författare)
  • Lee, Jennifer L. F.McGill Univ, Hlth Ctr, Div Clin Epidemiol, Montreal, PQ, Canada (författare)
  • Farinha, PedroUniv British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada;British Columbia Canc Agcy, Pathol Dept, Vancouver, BC, Canada;British Columbia Canc Agcy, Ctr Lymphoid Canc, Vancouver, BC, Canada (författare)
  • Bernatsky, SashaMcGill Univ, Hlth Ctr, Div Clin Epidemiol, Montreal, PQ, Canada;McGill Univ, Dept Med, Montreal, PQ, Canada (författare)
  • Univ British Columbia, Anat Pathol & Lab Med, Vancouver, BC, CanadaUniv British Columbia, Fac Med, Vancouver, BC, Canada (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Lupus Science and Medicine: BMJ PUBLISHING GROUP6:12053-8790

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