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  • Rönnberg, ElinKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Solna, Sweden (författare)

Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated Functions

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-06-19
  • FRONTIERS MEDIA SA,2019
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-390195
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390195URI
  • https://doi.org/10.3389/fimmu.2019.01361DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141170834URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma. Mast cells are one of the major targets of IL-33, to which they respond by secreting cytokines. Most studies performed thus far have investigated the acute effects of IL-33 on mast cells. In the current study, we investigated how acute vs. prolonged exposure of mast cells to IL-33 and TSLP affects mediator synthesis and IgE-mediated activation.Methods: Human lung mast cells (HLMCs), cord blood-derived mast cells (CBMCs), and the ROSA mast cell line were used for this study. Receptor expression and the levels of mediators were measured after treatment with IL-33 and/or TSLP.Results: IL-33 induced the release of cytokines. Prolonged exposure to IL-33 increased while TSLP reduced intracellular levels of tryptase. Acute IL-33 treatment strongly potentiated IgE-mediated activation. In contrast, 4 days of exposure to IL-33 decreased IgE-mediated activation, an effect that was accompanied by a reduction in Fc epsilon RI expression.Conclusion: We show that IL-33 plays dual roles in mast cells, in which its acute effects include cytokine release and the potentiation of IgE-mediated degranulation, whereas prolonged exposure to IL-33 reduces IgE-mediated activation. We conclude that mast cells act quickly in response to the alarmin IL-33 to initiate an acute inflammatory response, whereas extended exposure to IL-33 during prolonged inflammation reduces IgE-mediated responses. This negative feedback effect suggests the presence of a novel regulatory pathway that modulates IgE-mediated human mast cell responses.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ghaib, AvanKarolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Solna, Sweden;Univ Sulaimani, Coll Med, Dept Microbiol, Sulaimani, Iraq (författare)
  • Ceriol, CarlosKarolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Solna, Sweden (författare)
  • Enoksson, MattiasKarolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Solna, Sweden (författare)
  • Arock, MichelCNRS, UMR 8113, Ecole Normale Super Cachan, Mol & Cellular Oncol,LBPA, Cachan, France;Grp Hosp Pitie Salpetriere, Lab Cent Hematol, Paris, France (författare)
  • Säfholm, JesperKarolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Asthma & Allergy Res, Solna, Sweden (författare)
  • Orre, Ann-Charlotte (författare)
  • Al-Ameri, MamdohKarolinska Institutet (författare)
  • Adner, MikaelKarolinska Institutet (författare)
  • Dahlen, Sven-ErikKarolinska Institutet (författare)
  • Ekoff, MariaKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Solna, Sweden (författare)
  • Nilsson, GunnarUppsala universitet,Hematologi,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Solna, Sweden(Swepub:uu)gunnarns (författare)
  • Karolinska InstitutetKarolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Solna, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Immunology: FRONTIERS MEDIA SA101664-3224

Internetlänk

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