Asparaginase treatment in infants with acute lymphoblastic leukemia; pharmacokinetics and asparaginase hypersensitivity in Interfant-06

Albertsen, Birgitte KlugAarhus Univ Hosp, Children & Adolescent Hlth, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark (författare)

Acute lymphoblastic leukemia (ALL) is a rare disease in infants. Asparaginase is an essential part of the treatment, and there Acute is a need to evaluate the efficiency and safety of this drug in this age group. We evaluated the pharmacokinetics of intramuscularly administered native E. coli asparaginase (Asparaginase Medac((R))) and PEG-asparaginase (Oncaspar((R))) as well as hypersensitivity reactions during treatment in Interfant-06 (www.clinicaltrials.gov: NCT01025804). All patients without hypersensitivity had sufficiently high enzyme activity levels during treatment with both preparations. Patients with hypersensitivity reactions during treatment, characterized by the presence of either or not of clinical symptoms and no measurable enzyme activity, received ineffective therapy. For optimization of the bad prognosis in infant ALL, therapeutic drug monitoring should be performed for identification of patients who should be switched to a different asparaginase preparation because of inactivation of the drug.

Harila-Saari, ArjaUppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)arjha456 (författare)
Jahnukainen, KirsiUniv Helsinki, Childrens Hosp, Helsinki, Finland;Univ Helsinki, Cent Hosp, Helsinki, Finland (författare)
Lahteenmaki, PaiviTurku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland;Turku Univ, Turku, Finland (författare)
Riikonen, PekkaKuopio Univ Hosp, Dept Pediat, Kuopio, Finland (författare)
Mottonen, MerjaUniv Oulu, PEDEGO Res Ctr, Oulu, Finland;Univ Oulu, Med Res Ctr Oulu, Oulu, Finland;Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland (författare)
Lausen, BirgitteUniv Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark (författare)
Aarhus Univ Hosp, Children & Adolescent Hlth, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, DenmarkBarnneurologi/Barnonkologi (creator_code:org_t)

Ingår i:Leukemia and Lymphoma: TAYLOR & FRANCIS LTD60:6, s. 1469-14751042-81941029-2403

Av författaren/redakt...: Albertsen, Birgi ...; Harila-Saari, Ar ...; Jahnukainen, Kir ...; Lahteenmaki, Pai ...; Riikonen, Pekka; Mottonen, Merja; visa fler...; Lausen, Birgitte; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.