Search: WFRF:(Pasaniuc Bogdan) >
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Wu, LangVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA;Univ Hawaii Manoa, Canc Epidemiol Div, Populat Sci Pacific Program, Univ Hawaii Canc Ctr, Honolulu, HI 96822 USA
(author)
Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk : A Transcriptome-Wide Association Study in over 140,000 European Descendants
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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AMER ASSOC CANCER RESEARCH,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-390910
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390910URI
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https://doi.org/10.1158/0008-5472.CAN-18-3536DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141308026URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Genome-wide association study-identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain unknown. To discover novel prostate cancer genetic loci and possible causal genes at previously identified risk loci, we performed a transcriptome-wide association study in 79,194 cases and 61,112 controls of European ancestry. Using data from the Genotype-Tissue Expression Project, we established genetic models to predict gene expression across the transcriptome for both prostate models and cross-tissue models and evaluated model performance using two independent datasets. We identified significant associations for 137 genes at P < 2.61 x 10(-6), a Bonferroni-corrected threshold, including nine genes that remained significant at P < 2.61 x 10(-6) after adjusting for all known prostate cancer risk variants in nearby regions. Of the 128 remaining associated genes, 94 have not yet been reported as potential target genes at known loci. We silenced 14 genes and many showed a consistent effect on viability and colony-forming efficiency in three cell lines. Our study provides substantial new information to advance our understanding of prostate cancer genetics and biology. Significance: This study identifies novel prostate cancer genetic loci and possible causal genes, advancing our understanding of the molecular mechanisms that drive prostate cancer.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wang, JifengVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA;Fifth Peoples Hosp Shanghai, Dept Urol, Shanghai, Peoples R China
(author)
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Cai, QiuyinVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
(author)
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Cavazos, Taylor B.Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
(author)
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Emami, Nima C.Univ Calif San Francisco, Program Biol & Med Informat, San Francisco, CA 94143 USA;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
(author)
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Long, JirongVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
(author)
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Shu, Xiao-OuVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
(author)
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Lu, YingchangVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
(author)
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Guo, XingyiVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
(author)
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Bauer, Joshua A.Vanderbilt Univ, Dept Biochem, Sch Med, Nashville, TN 37203 USA;Vanderbilt Univ, Sch Med, Vanderbilt Inst Chem Biol, High Throughput Screening Facil, Nashville, TN 37203 USA
(author)
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Pasaniuc, BogdanUniv Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
(author)
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Penney, Kathryn L.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard Med Sch, Channing Div Network Med, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA
(author)
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Freedman, Matthew L.Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA;Broad Inst, Cambridge, MA USA
(author)
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Kote-Jarai, ZsofiaInst Canc Res, Div Genet & Epidemiol, London, England;Royal Marsden NHS Fdn Trust, London, England;Inst Canc Res, London, England
(author)
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Witte, John S.Univ Calif San Francisco, Program Biol & Med Informat, San Francisco, CA 94143 USA;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
(author)
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Haiman, Christopher A.Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA;Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA
(author)
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Eeles, Rosalind A.Inst Canc Res, Div Genet & Epidemiol, London, England;Royal Marsden NHS Fdn Trust, London, England;Inst Canc Res, London, England
(author)
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Zheng, WeiVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
(author)
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Benlloch, SaraInst Canc Res, London, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England
(author)
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Henderson, Brian E.Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA
(author)
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Conti, David, VUniv Southern Calif, Dept Prevent Med, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA
(author)
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Schumacher, Fredrick R.Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA;Univ Hosp Cleveland, Seidman Canc Ctr, Cleveland, OH 44106 USA
(author)
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Easton, DouglasUniv Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England
(author)
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Al Olama, Ali AminUniv Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England;Univ Cambridge, Dept Clin Neurosci, Cambridge, England
(author)
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Muir, KennethUniv Manchester, Div Populat Hlth Hlth Serv Res & Primary Care, Oxford Rd, Manchester, Lancs, England;Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England
(author)
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Berndt, Sonja, INCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
(author)
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Chanock, StephenNCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
(author)
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Albanes, DemetriusNCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
(author)
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Weinstein, StephanieNCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
(author)
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Koutros, StellaNCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
(author)
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Wildund, FredrikKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
(author)
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Gronberg, HenrikKarolinska Institutet
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Gapstur, Susan M.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
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Stevens, Victoria L.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
(author)
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Tangen, Catherine M.Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA
(author)
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Batra, JyotsnaQueensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia;Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia
(author)
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Clements, JudithAustralian Prostate Canc Res Ctr BioResource APCB, Translat Res Inst, Brisbane, Qld, Australia
(author)
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Pashayan, NoraUCL, Dept Appl Hlth Res, London, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Lab, Cambridge, England
(author)
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Schleutker, JohannaUniv Turku, Inst Biomed, Kiinamyllynkatu 10, FI-20014 Turku, Finland;Turku Univ Hosp, Tyks Microbiol & Genet, Dept Med Genet, Turku, Finland
(author)
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Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Div Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden(Swepub:uu)alwol516
(author)
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West, CatharineUniv Manchester, Christie Hosp NHS Fdn Trust, Manchester Acad Hlth Sci,Div Canc Sci, Radiotherapy Related Res,Manchester NIHR Biomed R, Manchester, Lancs, England
(author)
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Mucci, LoreleiHarvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
(author)
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Cancel-Tassin, GeraldineTenon Hosp, CeRePP, Paris, France;UPMC Sorbonne Univ, GRC ONCOTYPE URO 5, Tenon Hosp, 4 Rue Chine, Paris, France
(author)
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Sorensen, Karina DalsgaardAarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark;Aarhus Univ, Dept Clin Med, Aarhus, Denmark
(author)
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Grindedal, Eli MarieOslo Univ Hosp, Dept Med Genet, Oslo, Norway
(author)
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Neal, David E.Univ Cambridge, Dept Oncol, Addenbrookes Hosp, Cambridge, England;Canc Res UK Cambridge Res Inst, Li Ka Shing Ctr, Cambridge, England
(author)
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Hamdy, Freddie C.Univ Oxford, Nuffield Dept Surg Sci, Oxford, England;Univ Oxford, Fac Med Sci, John Radcliffe Hosp, Oxford, England
(author)
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Donovan, Jenny L.Univ Bristol, Sch Social & Community Med, Bristol, Avon, England
(author)
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Travis, Ruth C.Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England
(author)
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Hamilton, Robert J.Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada
(author)
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Rosenstein, Bany S.Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
(author)
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Lu, Yong-JieQueen Mary Univ London, Ctr Mol Oncol, Barts Canc Inst, John Vane Sci Ctr, London, England
(author)
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Giles, Graham G.Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia
(author)
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Kibel, Adam S.Brigham & Womens Hosp, Div Urol Surg, 75 Francis St, Boston, MA 02115 USA
(author)
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Vega, AnaIDIS, Fdn Publ Galega Med Xenom SERGAS, Grp Med Xenom, CIBERER, Santiago De Compostela, Spain
(author)
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Kogevinas, ManolisBarcelona Inst Global Hlth ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain;CIBERESP, Madrid, Spain;IMIM Hosp del Mar Res Inst, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain
(author)
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Park, Jong Y.H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA
(author)
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Stanford, Janet L.Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
(author)
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Newcomb, Lisa F.Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA;Univ Washington, Dept Urol, Seattle, WA 98195 USA
(author)
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Cybulski, CezaryPomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland
(author)
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Nordestgaard, Borge G.Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark;Copenhagen Univ Hosp, Dept Clin Biochem, Herlev & Gentofte Hosp, Herlev, Denmark
(author)
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Brenner, HermannGerman Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTZ, Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany
(author)
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Maier, ChristianUniv Hosp Ulm, Inst Human Genet, Ulm, Germany
(author)
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Kim, JeriUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
(author)
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John, Esther M.Stanford Univ, Dept Med Oncol, Sch Med, Stanford, CA USA;Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA
(author)
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Teixeira, Manuel R.Portuguese Oncol Inst Porto, Dept Genet, Porto, Portugal;Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal
(author)
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Neuhausen, Susan L.City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA
(author)
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De Ruyck, KimUniv Ghent, Fac Med & Hlth Sci, Basic Med Sci, Ghent, Belgium
(author)
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Razack, AzadUniv Malaya, Dept Surg, Fac Med, Kuala Lumpur, Malaysia
(author)
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Gamulin, MarijaUniv Med Ctr Hamburg Eppendorf, Inst Human Genet, Hamburg, Germany
(author)
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Kaneva, RadkaMed Univ, Mol Med Ctr, Dept Med Chem & Biochem, Sofia, Bulgaria
(author)
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Usmani, NawaidUniv Alberta, Dept Oncol, Cross Canc Inst, Edmonton, AB, Canada;Cross Canc Inst, Div Radiat Oncol, Edmonton, AB, Canada
(author)
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Claessens, FrankKatholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, Leuven, Belgium
(author)
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Townsend, Paul A.Univ Manchester, Manchester Canc Res Ctr, Hlth Innovat Manchester,Fac Biol Med & Hlth,Div C, Manchester Acad Hlth Sci Ctr,NIHR Manchester Biom, Manchester, Lancs, England
(author)
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Gago Dominguez, ManuelaComplejo Hosp Univ Santiago, Genom Med Grp, Serv Galego Saude,Galician Fdn Genom Med,SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela, Spain;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
(author)
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Roobol, Monique J.Erasmus MC, Dept Urol, Rotterdam, Netherlands
(author)
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Menegaux, FlorenceUniv Paris Saclay, Univ Paris Sud, Canc & Environm Grp, Ctr Res Epidemiol & Populat Hlth CESP,INSERM, Villejuif, France
(author)
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Khaw, Kay-TeeUniv Cambridge, Clin Gerontol Unit, Cambridge, England
(author)
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Cannon-Albright, LisaUniv Utah, Sch Med, Dept Med, Div Genet Epidemiol, Salt Lake City, UT USA;Vet Affairs Med Ctr, George E Wahlen Dept, Salt Lake City, UT 84148 USA
(author)
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Thibodeau, Stephen N.Univ Surrey, Guildford, Surrey, England;Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
(author)
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Hunter, David J.Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Dept Epidemiol, Boston, MA USA
(author)
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Blot, William J.Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med, Nashville, TN 37203 USA;Int Epidemiol Inst, Rockville, MD USA
(author)
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Riboli, ElioImperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England
(author)
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Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA;Univ Hawaii Manoa, Canc Epidemiol Div, Populat Sci Pacific Program, Univ Hawaii Canc Ctr, Honolulu, HI 96822 USAVanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA;Fifth Peoples Hosp Shanghai, Dept Urol, Shanghai, Peoples R China
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In:Cancer Research: AMER ASSOC CANCER RESEARCH79:13, s. 3192-32040008-54721538-7445
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Wu, Lang
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Wang, Jifeng
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Cai, Qiuyin
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Cavazos, Taylor ...
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Emami, Nima C.
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Long, Jirong
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Shu, Xiao-Ou
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Lu, Yingchang
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Pasaniuc, Bogdan
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Penney, Kathryn ...
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Freedman, Matthe ...
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Kote-Jarai, Zsof ...
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Witte, John S.
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Haiman, Christop ...
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Eeles, Rosalind ...
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Zheng, Wei
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Benlloch, Sara
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Henderson, Brian ...
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Conti, David, V
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Schumacher, Fred ...
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Easton, Douglas
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Al Olama, Ali Am ...
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Muir, Kenneth
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Berndt, Sonja, I
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Chanock, Stephen
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Albanes, Demetri ...
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Weinstein, Steph ...
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Koutros, Stella
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Wildund, Fredrik
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Gronberg, Henrik
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Gapstur, Susan M ...
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Stevens, Victori ...
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Tangen, Catherin ...
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Batra, Jyotsna
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Clements, Judith
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Pashayan, Nora
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Schleutker, Joha ...
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Wolk, Alicja
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West, Catharine
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Mucci, Lorelei
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Cancel-Tassin, G ...
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Sorensen, Karina ...
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Grindedal, Eli M ...
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Neal, David E.
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Hamdy, Freddie C ...
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Donovan, Jenny L ...
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Travis, Ruth C.
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Hamilton, Robert ...
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Rosenstein, Bany ...
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Lu, Yong-Jie
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Giles, Graham G.
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Kibel, Adam S.
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Vega, Ana
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Kogevinas, Manol ...
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Park, Jong Y.
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Stanford, Janet ...
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Newcomb, Lisa F.
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Cybulski, Cezary
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Nordestgaard, Bo ...
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Brenner, Hermann
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Maier, Christian
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Kim, Jeri
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John, Esther M.
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Teixeira, Manuel ...
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Neuhausen, Susan ...
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De Ruyck, Kim
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Razack, Azad
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Gamulin, Marija
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Kaneva, Radka
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Usmani, Nawaid
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Claessens, Frank
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Townsend, Paul A ...
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Gago Dominguez, ...
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Roobol, Monique ...
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Menegaux, Floren ...
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Khaw, Kay-Tee
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Cannon-Albright, ...
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Thibodeau, Steph ...
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Hunter, David J.
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Blot, William J.
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Riboli, Elio
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Uppsala University
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