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The Concentration o...
The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time
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- Prokopishyn, Nicole L. (författare)
- Univ Calgary, Dept Pathol & Lab Med, Calgary, AB, Canada
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- Logan, Brent R. (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA
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- Kiefer, Deidre M. (författare)
- Natl Marrow Donor Program Be Match, Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA
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visa fler...
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- Sees, Jennifer A. (författare)
- Natl Marrow Donor Program Be Match, Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA
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- Chitphakdithai, Pintip (författare)
- Natl Marrow Donor Program Be Match, Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA
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- Ahmed, Ibrahim A. (författare)
- Childrens Mercy Hosp & Clin, Dept Hematol Oncol & Bone Marrow Transplantat, Kansas City, MO USA
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- Anderlini, Paolo N. (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA
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- Beitinjaneh, Amer M. (författare)
- Univ Miami, Dept Hematol, Miami, FL USA
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- Bredeson, Christopher (författare)
- Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada;Ottawa Hosp Res Inst, Ottawa, ON, Canada
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- Cerny, Jan (författare)
- Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA
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- Chhabra, Saurabh (författare)
- Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA
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- Daly, Andrew (författare)
- Tom Baker Canc Clin, Calgary, AB, Canada
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- Angel Diaz, Miguel (författare)
- Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain
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- Farhadfar, Nosha (författare)
- Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA
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- Frangoul, Haydar A. (författare)
- TriStar Centennial, Childrens Hosp, Div Pediat Hematol & Oncol, Nashville, TN USA;Sarah Cannon Res Inst, Nashville, TN USA
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- Ganguly, Siddhartha (författare)
- Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA
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- Gastineau, Dennis A. (författare)
- Mayo Clin Rochester, Div Hematol, Rochester, MN USA
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- Gergis, Usama (författare)
- Weill Cornell Med Coll, New York Presbyterian Hosp, Dept Med Oncol, Hematolg Malignancies & Bone Marrow Transplant, New York, NY USA
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- Hale, Gregory A. (författare)
- Johns Hopkins All Childrens Hosp, Dept Hematol Oncol, St Petersburg, FL USA
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- Hematti, Peiman (författare)
- Univ Wisconsin Hosp & Clin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI 53792 USA
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- Kamble, Rammurti T. (författare)
- Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA
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- Kasow, Kimberly A. (författare)
- Univ N Carolina, Div Hematol Oncol, Dept Pediat, Chapel Hill, NC 27515 USA
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- Lazarus, Hillard M. (författare)
- Univ Hosp Cleveland, Med Ctr, Seidman Canc Ctr, Cleveland, OH 44106 USA
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- Liesveld, Jane L. (författare)
- Univ Rochester, Med Ctr, Strong Mem Hosp, Rochester, NY 14642 USA
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- Murthy, Hemant S. (författare)
- Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA
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- Norkin, Maxim (författare)
- Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA
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- Olsson, Richard (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden
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- Papari, Mona (författare)
- ITxM Clin Serv Cord Blood Lab, Rosemont, IL USA
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- Savani, Bipin N. (författare)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA
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- Szer, Jeffrey (författare)
- Peter MacCalluma Canc Ctr, Clin Haematol, Melbourne, Vic, Australia;Royal Melbourne Hosp, Parkville, Vic, Australia
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- Waller, Edmund K. (författare)
- Emory Univ Hosp, Dept Hematol & Meidcal Oncol, 1364 Clifton Rd NE, Atlanta, GA 30322 USA
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- Wirk, Baldeep (författare)
- Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA
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- Yared, Jean A. (författare)
- Univ Maryland, Greenebaum Canc Ctr, Blood & Marrow Transplantat Program, Div Hematol Oncol,Dept Med, Baltimore, MD 21201 USA
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- Pulsipher, Michael A. (författare)
- USC Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA USA
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- Shah, Nirali N. (författare)
- NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
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- Switzer, Galen E. (författare)
- Univ Pittsburgh, Dept Med, Pittsburgh, PA USA
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- O'Donnell, Paul V. (författare)
- Harvard Med Sch, Massachusetts Gen Hosp, Dept Hematol Oncol, Boston, MA 02115 USA
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- Confer, Dennis L. (författare)
- Natl Marrow Donor Program Be Match, Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA;Natl Marrow Donor Program Be Match, Minneapolis, MN USA
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- Shaw, Bronwen E. (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2019
- 2019
- Engelska.
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Ingår i: Biology of blood and marrow transplantation. - : ELSEVIER SCIENCE INC. - 1083-8791 .- 1523-6536. ; 25:7, s. 1325-1330
- Relaterad länk:
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http://www.bbmt.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Bone marrow (BM) is an essential source of hematopoietic stem cell grafts for many allogeneic hematopoietic cell transplant (HCT) recipients, including adult patients (for specific diseases and transplantation strategies) and the majority of pediatric recipient. However, since the advent of granulocyte colony-stimulating factor-mobilized peripheral blood stem cell (PBSC) grafts, there has been a significant decrease in the use of BM in HCT, thought to be due mainly to the increased logistical challenges in harvesting BM compared with PBSCs, as well as generally no significant survival advantage of BM over PBSCs. The decreased frequency of collection has the potential to impact the quality of BM harvests. In this study, we examined >15,000 BM donations collected at National Marrow Donor Program centers between 1994 and 2016 and found a significant decline in the quality of BM products, as defined by the concentration of total nucleated cells (TNCs). The mean TNC concentration in BM donations dropped from 21.8 x 10(6) cells/mL in the earliest era (1994 to 1996) to 18.7 x 10(6) cells/mL in the most recent era (2012 to 2016) (means ratio,.83; P < .001). This decline in BM quality was seen despite the selection of more donors perceived to be optimal (eg, younger and male). Multivariate regression analysis showed that higher volume centers (performing >30 collections per era) had better-quality harvests with higher concentrations of TNCs collected. In conclusion, we have identified a significant decrease in the quality of BM collections over time, and lower-volume collection centers had poorer-quality harvests. In this analysis, we could not elucidate the direct cause for this finding, suggesting the need for further studies to investigate the key factors responsible and to explore the impact on transplant recipients. (C) 2019 American Society for Blood and Marrow Transplantation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Unrelated donor
- Bone marrow
- Total nucleated cells
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Prokopishyn, Nic ...
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Logan, Brent R.
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Kiefer, Deidre M ...
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Sees, Jennifer A ...
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Chitphakdithai, ...
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Ahmed, Ibrahim A ...
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visa fler...
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Anderlini, Paolo ...
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Beitinjaneh, Ame ...
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Bredeson, Christ ...
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Cerny, Jan
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Chhabra, Saurabh
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Daly, Andrew
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Angel Diaz, Migu ...
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Farhadfar, Nosha
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Frangoul, Haydar ...
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Ganguly, Siddhar ...
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Gastineau, Denni ...
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Gergis, Usama
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Hale, Gregory A.
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Hematti, Peiman
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Kamble, Rammurti ...
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Kasow, Kimberly ...
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Lazarus, Hillard ...
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Liesveld, Jane L ...
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Murthy, Hemant S ...
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Norkin, Maxim
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Olsson, Richard
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Papari, Mona
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Savani, Bipin N.
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Szer, Jeffrey
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Waller, Edmund K ...
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Wirk, Baldeep
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Yared, Jean A.
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Pulsipher, Micha ...
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Shah, Nirali N.
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Switzer, Galen E ...
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O'Donnell, Paul ...
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Confer, Dennis L ...
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Shaw, Bronwen E.
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- MEDICIN OCH HÄLSOVETENSKAP
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och Hematologi
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Biology of blood ...
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Uppsala universitet
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Karolinska Institutet