Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis

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Yi-Ting, LinUppsala universitet,Molekylär epidemiologi,Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan (author)

Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis

Article/chapterEnglish2019

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Elsevier BV,2019
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LIBRIS-ID:oai:DiVA.org:uu-392874
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392874URI
https://doi.org/10.1016/j.neuro.2019.02.019DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Patients receiving hemodialysis (HD) have a higher risk of cognitive impairment and dementia than the general population. The accumulation of uremic toxins in the brain causes uremic encephalopathy, however, limited data exists to elucidate the effect of protein-bound uremic toxins on cognitive function. Here we investigate the effect of indole-3 acetic acid (IAA) and hippuric acid (HA), two different protein-bound uremic toxins from amino acid derivatives, on cognitive function by Silico and in a clinical study. Prevalent HD patients were enrolled in two independent hospitals. Serum IAA and HA were measured using mass spectrometry. Cognitive performance was measured using Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Cognitive Abilities Screening Instrument (CASI) by trained psychologists. Using silico data to predict the effect of blood-brain barrier penetration was performed. The silico data demonstrated that IAA and HA had positive blood-brain barrier penetration ability. Amongst the 230 HD patients, serum IAA was associated with poor MMSE score (beta = -0.90, 95% CI -1.61 to -0.19) and poor CASI score (beta = -3.29, 95% CI -5.69 to -0.88) in stepwise multiple linear regression analysis. In logistic regression model, Serum IAA was also associated with cognitive impairment based on MMSE definition (OR, 1.96, 95% CI 1.10, 3.5) and CASI definition (OR, 2.09, 95% CI 1.21, 3.61). There was no correlation between Serum HA levels and cognitive function status. In conclusion, IAA, not HA, was associated with cognitive impairment in HD patients. Further large scale and prospective studies are needed to confirm our findings.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Indole-3 acetic acid
Cognitive function
Dementia
Chronic kidney disease
Hemodialysis

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Wu, Ping-HsunKaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan(Swepub:uu)pinwu324 (author)
Lee, Hei-HwaKaohsiung Med Univ Hosp, Dept Lab Med, Kaohsiung, Taiwan (author)
Mubanga, MwenyaUppsala universitet,Molekylär epidemiologi(Swepub:uu)mwemu876 (author)
Chen, Cheng-ShengKaohsiung Med Univ, Coll Med, Dept Psychiat, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Psychiat, Kaohsiung, Taiwan (author)
Kuo, Mei-ChuanKaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan (author)
Chiu, Yi-WenKaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan (author)
Kuo, Po-LinKaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan (author)
Hwang, Shang-JyhKaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan;Natl Hlth Res Inst, Inst Populat Sci, Miaoli, Taiwan (author)
Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

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In:Neurotoxicology: Elsevier BV73, s. 85-910161-813X1872-9711

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By the author/editor: Yi-Ting, Lin; Wu, Ping-Hsun; Lee, Hei-Hwa; Mubanga, Mwenya; Chen, Cheng-Shen ...; Kuo, Mei-Chuan; show more...; Chiu, Yi-Wen; Kuo, Po-Lin; Hwang, Shang-Jyh; show less...

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