Investigating Maternal Brain Alterations in Preeclampsia: the Need for a Multidisciplinary Effort

Bergman, LinaUppsala universitet,Centrum för klinisk forskning Dalarna,Klinisk obstetrik (författare)

Investigating Maternal Brain Alterations in Preeclampsia : the Need for a Multidisciplinary Effort

PURPOSE OF REVIEW: To provide insight into the mechanisms underlying cerebral pathophysiology and to highlight possible methods for evaluation, screening, and surveillance of cerebral complications in preeclampsia.RECENT FINDINGS: The pathophysiology of eclampsia remains enigmatic. Animal studies show that the cerebral circulation in pregnancy and preeclampsia might be affected with increased permeability over the blood-brain barrier and altered cerebral blood flow due to impaired cerebral autoregulation. The increased blood pressure cannot be the only underlying cause of eclampsia and cerebral edema, since some cases of eclampsia arise without simultaneous hypertension. Findings from animal studies need to be confirmed in human tissues. Evaluation of brain alterations in preeclampsia and eclampsia is challenging and demands a multidisciplinary collaboration, since no single method can accurately and fully describe how preeclampsia affects the brain. Cerebral complications of preeclampsia are significant factors in maternal morbidity and mortality worldwide. No single method can accurately describe the full picture of how preeclampsia affects the brain vasculature and parenchyma. We recommend an international and multidisciplinary effort not only to overcome the issue of limited sample availability but also to optimize the quality of research.

Torres-Vergara, PabloUniv Concepcion, Fac Pharm, Pharm Dept, Concepcion, Chile ;Grp Res & Innovat Vasc Hlth GRIVAS Hlth, Chillan, Chile (författare)
Penny, JeffreyUniv Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Div Pharm & Optometry, Manchester, Lancs, England (författare)
Wikström, Johan,1964-Uppsala universitet,Radiologi(Swepub:uu)jwi06759 (författare)
Nelander, MariaUppsala universitet,Klinisk obstetrik(Swepub:uu)marne691 (författare)
Leon, JoseGrp Res & Innovat Vasc Hlth GRIVAS Hlth, Chillan, Chile ; Univ Bio Bio, Fac Sci, Grp Invest Tumor Angiogenesis LFV GIANT, Vasc Physiol Lab,Dept Basic Sci, Chillan, Chile (författare)
Tolcher, MaryUppsala universitet,Klinisk obstetrik (författare)
Roberts, James MUniv Pittsburgh, Magee Womens Res Inst, Dept Obstet Gynecol & Reprod Sci, Epidemiol & Clin & Translat Res, Pittsburgh, PA USA (författare)
Wikström, Anna-Karin,1965-Karolinska Institutet,Uppsala universitet,Klinisk obstetrik(Swepub:uu)annwi179 (författare)
Escudero, CarlosGrp Res & Innovat Vasc Hlth GRIVAS Hlth, Chillan, Chile ; Univ Bio Bio, Fac Sci, Grp Invest Tumor Angiogenesis LFV GIANT, Vasc Physiol Lab,Dept Basic Sci, Chillan, Chile (författare)
Uppsala universitetCentrum för klinisk forskning Dalarna (creator_code:org_t)

Ingår i:Current Hypertension Reports: Springer Science and Business Media LLC21:91522-64171534-3111

Av författaren/redakt...: Bergman, Lina; Torres-Vergara, ...; Penny, Jeffrey; Wikström, Johan, ...; Nelander, Maria; Leon, Jose; visa fler...; Tolcher, Mary; Roberts, James M; Wikström, Anna-K ...; Escudero, Carlos; visa färre...

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