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Circulating secreto...
Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis
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- Brynildsen, Jon (author)
- Akershus Univ Hosp, Dept Cardiol, Div Med, Lorenskog, Norway;Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway
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- Myhre, Peder L. (author)
- Akershus Univ Hosp, Dept Cardiol, Div Med, Lorenskog, Norway;Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway
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- Lyngbakken, Magnus N. (author)
- Akershus Univ Hosp, Dept Cardiol, Div Med, Lorenskog, Norway;Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway
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- Klaeboe, Lars Gunnar (author)
- Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway;Oslo Univ Hosp, Rikshosp, Dept Cardiol, Oslo, Norway
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- Stridsberg, Mats (author)
- Uppsala universitet,Biokemisk endokrinologi
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- Christensen, Geir (author)
- Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway;Oslo Univ Hosp, Inst Expt Med Res, Ulleval, Norway
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- Edvardsen, Thor (author)
- Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway;Oslo Univ Hosp, Rikshosp, Dept Cardiol, Oslo, Norway
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- Omland, Torbjorn (author)
- Akershus Univ Hosp, Dept Cardiol, Div Med, Lorenskog, Norway;Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway
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- Rosjo, Helge (author)
- Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway;Akershus Univ Hosp, Div Res & Innovat, Sykehusveien 25, N-1478 Lorenskog, Norway
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(creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2019
- 2019
- English.
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In: Clinical Biochemistry. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0009-9120 .- 1873-2933. ; 71, s. 17-23
- Related links:
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https://www.duo.uio....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Secretoneurin (SN) concentrations provide important prognostic information in patients with myocardial dysfunction. Whether preoperative SN concentrations improve risk assessment in patients with moderate to severe aortic stenosis (AS) is unknown. Methods: We included 57 patients with moderate to severe AS referred for presurgical evaluation. All patients were examined with comprehensive echocardiography, electrocardiogram (ECG), and biochemical measurements and compared to 10 age- and sex-matched healthy subjects. Results: Median (quartile 1-3) SN concentrations were 141 (121-163) pmol/L in AS patients and 132 (106-148) pmol/L in control subjects (p = .17). Lower estimated creatinine clearance and use of diuretics, but not standard ECG or echocardiographic indices and cardiac biomarkers, were associated with increasing SN concentrations. Fifteen patients (26%) died during 3.5 years median follow-up. SN concentrations were higher in non-survivors than survivors: 156 (133-209) vs. 140 (116-155) pmol/L, p = .007. Higher SN concentrations were associated with increased risk of mortality also after adjustment for established risk indices, biomarkers, and status regarding valvular surgery: hazard ratio per lnSN 15.13 (95% CI 1.05-219.00); p = .046. Receiver operating characteristics area under the curve for SN to predict mortality was 0.74 (95% CI 0.60-0.88) compared to 0.73 (0.59-0.87) for high-sensitivity cardiac troponin T and 0.67 (0.51-0.82) for N-terminal pro-B-type natriuretic peptide. The previously identified cut-off of SN > 204 pmol/L in cardiac surgical patients predicted mortality also in this cohort. Conclusions: SN concentrations improve risk assessment in patients with moderate to severe AS by providing additional prognostic information to established risk indices such as echocardiography, ECG, and established cardiac biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Aortic stenosis
- Biomarkers
- Secretoneurin
- Cardiac surgery
- Echocardiography
Publication and Content Type
- ref (subject category)
- art (subject category)
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