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Search: L773:1475 0961 > (2015-2019) > Microvascular capil...

  • Henriksson, PeterKarolinska Institutet (author)

Microvascular capillary assessment in relation to forearm blood flow

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-05-30
  • WILEY,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-393648
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-393648URI
  • https://doi.org/10.1111/cpf.12575DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141583500URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective To study whether vascular reactivity as assessed by the methods forearm blood flow (FBF) and postocclusive reactive hyperaemia (PRH) in the nail fold was related as a measure of endothelium-dependent vasodilation in the microcirculation. Methods Microvascular reactivity was assessed in forearm blood flow and in the nail fold by vital capillaroscopy of individual microvessels as postocclusive reactive hyperaemia. Vascular reactivity was assessed at baseline (n = 25) as well as after infusion of acetylcholine and of sodium nitroprusside (n = 13). We also performed a multivariate regression analysis to assess whether forearm blood flow or flow-mediated dilatation related to postocclusive reactive hyperaemia. Results This study showed a distinct microvascular response to both acetylcholine (endothelium-dependent vasodilation) and sodium nitroprusside (endothelium-independent vasodilation) during forearm blood flow assessment and postocclusive reactive hyperaemia assessment in the nail fold (n = 13). These changes were inversely related (r- = -0 center dot 57; P<0 center dot 05). Conclusions Forearm blood flow was inversely correlated to postocclusive reactive hyperaemia. Postocclusive reactive hyperaemia was shortened after infusion with both acetylcholine and sodium nitroprusside. This occurred in parallel with the expected increase in forearm blood flow, conceivably reflecting that both methods can be used to assess endothelium-dependent vasodilation in the microcirculation.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind (author)
  • Qing, LuKarolinska Univ Hosp, Div Clin Chem, Stockholm, Sweden (author)
  • Freyschuss, AnnaKarolinska Institutet (author)
  • Karolinska InstitutetKlinisk epidemiologi (creator_code:org_t)

Related titles

  • In:Clinical Physiology and Functional Imaging: WILEY39:5, s. 322-3261475-09611475-097X

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Henriksson, Pete ...
Lind, Lars
Qing, Lu
Freyschuss, Anna
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Physiology
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Clinical Physiol ...
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Uppsala University
Karolinska Institutet

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