SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(He Xiaoxiang)
 

Sökning: WFRF:(He Xiaoxiang) > A Discovery of a Ge...

  • Li, JinxiuChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China;Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing, Peoples R China (författare)

A Discovery of a Genetic Mutation Causing Reduction of Atrogin-1 Expression in Broiler Chicken Muscle

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-08-15
  • FRONTIERS MEDIA SA,2019
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-393656
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-393656URI
  • https://doi.org/10.3389/fgene.2019.00716DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Chickens are bred all over the world and have significant economic value as one of the major agricultural animals. The growth rate of commercial broiler chickens is several times higher than its Red Jungle fowl (RJF) ancestor. To further improve the meat production of commercial chickens, it is quite important to decipher the genetic mechanism of chicken growth traits. In this study, we found that broiler chickens exhibited lower levels of E3 ubiquitin ligase muscle atrophy F-box (MAFbx or Atrogin-1) relative to its RJF ancestor. As a ubiquitin ligase, Atrogin-1 plays a crucial role in muscle development in which its up-regulation often indicates the activation of muscle atrophic pathways. Here, we showed that the Atrogin-1 expression variance partly affects chicken muscle growth rates among different breeds. Furthermore, we demonstrated that the reduced expression of Atrogin-1 in broiler chickens was ascribed to a single nucleotide polymorphism (SNP), which inhibited the binding of transcription regulators and attenuated the enhancer activity. The decreased Atrogin-1 in broiler chickens suppresses the catabolism of muscle protein and preserves muscle mass. Our study facilitates the understanding of the molecular mechanism of chicken muscle development and has a high translational impact in chicken breeding.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hu, YiqingChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Li, LiChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Wang, YuzheChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Li, QingheChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Feng, ChungangChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Lan, HeChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Gu, XiaorongChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Zhao, YiqiangChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Larsson, MårtenUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)mla24680 (författare)
  • Hu, XiaoxiangChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (författare)
  • Li, NingChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China;China Agr Univ, Natl Engn Lab Anim Breeding, Beijing, Peoples R China;Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming, Yunnan, Peoples R China (författare)
  • China Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China;Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing, Peoples R ChinaChina Agr Univ, Coll Biol Sci, State Key Labs Agrobiotechnol, Beijing, Peoples R China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Genetics: FRONTIERS MEDIA SA101664-8021

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy