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Treatment Outcomes ...
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Dickstein, YaakovMinist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel
(author)
Treatment Outcomes of Colistin- and Carbapenem-resistant Acinetobacter baumannii Infections : An Exploratory Subgroup Analysis of a Randomized Clinical Trial
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2018-11-20
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OXFORD UNIV PRESS INC,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-394059
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-394059URI
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https://doi.org/10.1093/cid/ciy988DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background We evaluated the association between mortality and colistin resistance in Acinetobacter baumannii infections and the interaction with antibiotic therapy. Methods This is a secondary analysis of a randomized controlled trial of patients with carbapenem-resistant gram-negative bacterial infections treated with colistin or colistin-meropenem combination. We evaluated patients with infection caused by carbapenem-resistant A. baumannii (CRAB) identified as colistin susceptible (CoS) at the time of treatment and compared patients in which the isolate was confirmed as CoS with those whose isolates were retrospectively identified as colistin resistant (CoR) when tested by broth microdilution (BMD). The primary outcome was 28-day mortality. Results Data were available for 266 patients (214 CoS and 52 CoR isolates). Patients with CoR isolates had higher baseline functional capacity and lower rates of mechanical ventilation than patients with CoS isolates. All-cause 28-day mortality was 42.3% (22/52) among patients with CoR strains and 52.8% (113/214) among patients with CoS isolates (P = .174). After adjusting for variables associated with mortality, the mortality rate was lower among patients with CoR isolates (odds ratio [OR], 0.285 [95% confidence interval {CI}, .118-.686]). This difference was associated with treatment arm: Mortality rates among patients with CoR isolates were higher in those randomized to colistin-meropenem combination therapy compared to colistin monotherapy (OR, 3.065 [95% CI, 1.021-9.202]). Conclusions Colistin resistance determined by BMD was associated with lower mortality among patients with severe CRAB infections. Among patients with CoR isolates, colistin monotherapy was associated with a better outcome compared to colistin-meropenem combination therapy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lellouche, JonathanMinist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Sourasky Med Ctr, Mol Epidemiol Lab, Tel Aviv, Israel
(author)
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Amar, Maayan Ben DalakMinist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Sourasky Med Ctr, Mol Epidemiol Lab, Tel Aviv, Israel
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Schwartz, DavidMinist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Sourasky Med Ctr, Mol Epidemiol Lab, Tel Aviv, Israel
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Nutman, AmirMinist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel
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Daitch, VeredTel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel;Beilinson Med Ctr, Rabin Med Ctr, Dept Med E, Petah Tiqwa, Israel
(author)
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Yahav, DafnaTel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel;Beilinson Med Ctr, Rabin Med Ctr, Unit Infect Dis, Petah Tiqwa, Israel
(author)
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Leibovici, LeonardTel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel;Beilinson Med Ctr, Rabin Med Ctr, Dept Med E, Petah Tiqwa, Israel
(author)
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Skiada, AnnaLaikon Gen Hosp, Dept Med 1, Athens, Greece;Univ Athens, Athens, Greece
(author)
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Antoniadou, AnastasiaUniv Athens, Athens, Greece;Attikon Univ Gen Hosp, Dept Med 4, Athens, Greece
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Daikos, George L.Laikon Gen Hosp, Dept Med 1, Athens, Greece;Univ Athens, Athens, Greece
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Andini, RobertoUniv Campania L Vanvitelli, Dept Precis Med, Naples, Italy;Azienda Osped Rilievo Nazl Colli Monaldi Hosp, Naples, Italy
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Zampino, RosaUniv Campania L Vanvitelli, Dept Precis Med, Naples, Italy;Azienda Osped Rilievo Nazl Colli Monaldi Hosp, Naples, Italy
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Durante-Mangoni, EmanueleUniv Campania L Vanvitelli, Dept Precis Med, Naples, Italy;Azienda Osped Rilievo Nazl Colli Monaldi Hosp, Naples, Italy
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Mouton, Johan W.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
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Friberg, LenaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)lenasimo
(author)
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Benattar, Yael DishonRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel;Univ Haifa, Cheryl Spencer Dept Nursing, Haifa, Israel
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Bitterman, RoniRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel
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Neuberger, AmiRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel
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Carmeli, YehudaMinist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Sourasky Med Ctr, Mol Epidemiol Lab, Tel Aviv, Israel;Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel
(author)
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Paul, MicalMinist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Rambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel;Technion Israel Inst Technol, Fac Med, Haifa, Israel
(author)
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Zayyad, Hiba
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Koppel, Fidi
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Zak-Doron, Yael
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Altunin, Sergey
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Andria, Nizar
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Stern, Anat
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Petersiel, Neta
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Raines, Marina
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Karban, Amir
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Eliakim-Raz, Noa
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Zusman, Oren
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Elbaz, Michal
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Atamna, Heyam
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Babich, Tanya
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Adler, Amos
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Levi, Inbar
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Pavleas, Ioannis
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Kotsaki, Antigoni
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Iossa, Domenico
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Bernardo, Mariano
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Cavezza, Giusi
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Bertolino, Lorenzo
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Giuffre, Giuseppe
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Giurazza, Roberto
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Cuccurullo, Susanna
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Galdo, Maria
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Murino, Patrizia
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Cristinziano, Adriano
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Corcione, Antonio
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Pafundi, Pia Clara
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Mouton, Johan
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Friberg, Lena
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Kristoffersson, Anders
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Theuretzbacher, Ursula
(author)
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Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, IsraelMinist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Sourasky Med Ctr, Mol Epidemiol Lab, Tel Aviv, Israel
(creator_code:org_t)
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In:Clinical Infectious Diseases: OXFORD UNIV PRESS INC69:5, s. 769-7761058-48381537-6591
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Dickstein, Yaako ...
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Lellouche, Jonat ...
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Amar, Maayan Ben ...
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Schwartz, David
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Nutman, Amir
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Daitch, Vered
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Yahav, Dafna
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Leibovici, Leona ...
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Skiada, Anna
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Antoniadou, Anas ...
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Daikos, George L ...
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Andini, Roberto
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Zampino, Rosa
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Durante-Mangoni, ...
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Mouton, Johan W.
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Friberg, Lena
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Benattar, Yael D ...
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Bitterman, Roni
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Neuberger, Ami
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Carmeli, Yehuda
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Paul, Mical
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Zayyad, Hiba
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Koppel, Fidi
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Zak-Doron, Yael
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Altunin, Sergey
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Andria, Nizar
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Stern, Anat
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Petersiel, Neta
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Raines, Marina
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Karban, Amir
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Eliakim-Raz, Noa
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Zusman, Oren
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Elbaz, Michal
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Atamna, Heyam
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Babich, Tanya
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Adler, Amos
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Levi, Inbar
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Pavleas, Ioannis
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Kotsaki, Antigon ...
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Iossa, Domenico
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Bernardo, Marian ...
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Cavezza, Giusi
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Bertolino, Loren ...
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Giuffre, Giusepp ...
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Giurazza, Robert ...
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Cuccurullo, Susa ...
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Galdo, Maria
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Murino, Patrizia
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Cristinziano, Ad ...
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Corcione, Antoni ...
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Pafundi, Pia Cla ...
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Mouton, Johan
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Kristoffersson, ...
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Theuretzbacher, ...
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