SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Siljander Heli)
 

Sökning: WFRF:(Siljander Heli) > Early Detection of ...

Early Detection of Peripheral Blood Cell Signature in Children Developing beta-Cell Autoimmunity at a Young Age

Kallionpää, Henna (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
Somani, Juhi (författare)
Aalto Univ, Dept Comp Sci, Sch Sci, Espoo, Finland
Tuomela, Soile (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
visa fler...
Ullah, Ubaid (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
de Albuquerque, Rafael (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
Lönnberg, Tapio (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
Komsi, Elina (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
Siljander, Heli (författare)
Univ Helsinki, Childrens Hosp, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Res Programs Unit, Diabet & Obes, Helsinki, Finland
Honkanen, Jarno (författare)
Univ Helsinki, Childrens Hosp, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Res Programs Unit, Diabet & Obes, Helsinki, Finland
Härkönen, Taina (författare)
Univ Helsinki, Childrens Hosp, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Res Programs Unit, Diabet & Obes, Helsinki, Finland
Peet, Aleksandr (författare)
Univ Tartu, Dept Pediat, Tartu, Estonia; Tartu Univ Hosp, Childrens Clin Tartu, Tartu, Estonia
Tillmann, Vallo (författare)
Univ Tartu, Dept Pediat, Tartu, Estonia; Tartu Univ Hosp, Childrens Clin Tartu, Tartu, Estonia
Chandra, Vikash (författare)
Univ Helsinki, Childrens Hosp, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Fac Med, Mol Neurol & Biomed Stem Cell Ctr, Res Programs Unit, Helsinki, Finland
Anagandula, Mahesh Kumar, 1982- (författare)
Uppsala universitet,Klinisk immunologi
Frisk, Gun (författare)
Uppsala universitet,Klinisk immunologi
Otonkoski, Timo (författare)
Univ Helsinki, Childrens Hosp, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Fac Med, Mol Neurol & Biomed Stem Cell Ctr, Res Programs Unit, Helsinki, Finland
Rasool, Omid (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
Lund, Riikka (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
Lähdesmäki, Harri (författare)
Aalto Univ, Dept Comp Sci, Sch Sci, Espoo, Finland
Knip, Mikael (författare)
Univ Helsinki, Childrens Hosp, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Res Programs Unit, Diabet & Obes, Helsinki, Finland; Folkhälsan Res Ctr, Helsinki, Finland; Tampere Univ Hosp, Tampere Ctr Child Hlth Res, Tampere, Finland
Lahesmaa, Riitta (författare)
Univ Turku, Turku Biosci Ctr, Turku, Finland; Åbo Akad Univ, Turku, Finland
visa färre...
 (creator_code:org_t)
2019-07-16
2019
Engelska.
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 68:10, s. 2024-2034
Relaterad länk:
https://diabetes.dia...
visa fler...
https://urn.kb.se/re...
https://doi.org/10.2...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The appearance of type 1 diabetes (T1D)-associated autoantibodies is the first and only measurable parameter to predict progression toward T1D in genetically susceptible individuals. However, autoantibodies indicate an active autoimmune reaction, wherein the immune tolerance is already broken. Therefore, there is a clear and urgent need for new biomarkers that predict the onset of the autoimmune reaction preceding autoantibody positivity or reflect progressive beta-cell destruction. Here we report the mRNA sequencing-based analysis of 306 samples including fractionated samples of CD4(+) and CD8(+) T cells as well as CD4(-)CD8(-) cell fractions and unfractionated peripheral blood mononuclear cell samples longitudinally collected from seven children who developed beta-cell autoimmunity (case subjects) at a young age and matched control subjects. We identified transcripts, including interleukin 32 (IL32), that were upregulated before T1D-associated autoantibodies appeared. Single-cell RNA sequencing studies revealed that high IL32 in case samples was contributed mainly by activated T cells and NK cells. Further, we showed that IL32 expression can be induced by a virus and cytokines in pancreatic islets and beta-cells, respectively. The results provide a basis for early detection of aberrations in the immune system function before T1D and suggest a potential role for IL32 in the pathogenesis of T1D.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

  • Diabetes (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy