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Isacson, DanielUppsala universitet,Kolorektalkirurgi,Centrum för klinisk forskning, Västerås
(författare)
Long-term follow-up of the AVOD randomized trial of antibiotic avoidance in uncomplicated diverticulitis
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-08-06
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WILEY,2019
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-396118
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396118URI
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https://doi.org/10.1002/bjs.11239DOI
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Språk:engelska
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Sammanfattning på:engelska
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Background: The aim of this study was to assess the long-term results in patients with uncomplicated diverticulitis who had participated in the Antibiotics in Acute Uncomplicated Diverticulitis (AVOD) RCT, which randomized patients with CT-verified left-sided acute uncomplicated diverticulitis to management without or with antibiotics.Methods: The medical records of patients who had participated in the AVOD trial were reviewed for long-term results such as recurrences, complications and surgery. Quality-of-life questionnaires (EQ-5D (TM)) were sent to patients, who were also contacted by telephone. Descriptive statistics were used for the analysis of clinical outcomes.Results: A total of 556 of the 623 patients (89 center dot 2 per cent) were followed up for a median of 11 years. There were no differences between the no-antibiotic and antibiotic group in recurrences (both 31 center dot 3 per cent; P = 0 center dot 986), complications (4 center dot 4 versus 5 center dot 0 per cent; P = 0 center dot 737), surgery for diverticulitis (6 center dot 2 versus 7 center dot 1 per cent; P = 0 center dot 719) or colorectal cancer (0 center dot 4 versus 2 center dot 1 per cent; P = 0 center dot 061). The response rate for the EQ-5D (TM) was 52 center dot 8 versus 45 center dot 2 per cent respectively (P = 0 center dot 030), and no differences were found between the two groups in any of the measured dimensions.Conclusion: Antibiotic avoidance for uncomplicated diverticulitis is safe in the long term.
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Smedh, KennetUppsala universitet,Centrum för klinisk forskning, Västerås,Kolorektalkirurgi(Swepub:uu)kensm722
(författare)
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Hosseinali Khani, Maziar,1975-Uppsala universitet,Centrum för klinisk forskning, Västerås,Kolorektalkirurgi(Swepub:uu)mazho292
(författare)
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Chabok, Abbas,1964-Uppsala universitet,Kolorektalkirurgi,Centrum för klinisk forskning, Västerås,Uppsala Univ, Vastmanlands Hosp Vasteras, Dept Surg, Colorectal Unit, S-72189 Vasteras, Sweden(Swepub:uu)abbch956
(författare)
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Uppsala universitetKolorektalkirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Surgery: WILEY106:11, s. 1542-15480007-13231365-2168
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