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Aiming toWards Evid...
Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain-the WESTCOR study : study design
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- Tjora, Hilde L. (författare)
- Haukeland Hosp, Emergency Care Clin, Bergen, Norway
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- Steiro, Ole-Thomas (författare)
- Haukeland Hosp, Dept Heart Dis, Bergen, Norway
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- Langorgen, Jorund (författare)
- Haukeland Hosp, Dept Heart Dis, Bergen, Norway
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- Bjorneklett, Rune (författare)
- Haukeland Hosp, Emergency Care Clin, Bergen, Norway;Univ Bergen, Dept Clin Med, Bergen, Norway
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- Nygard, Ottar K. (författare)
- Haukeland Hosp, Dept Heart Dis, Bergen, Norway;Univ Bergen, Dept Clin Sci, Bergen, Norway
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- Renstrom, Renate (författare)
- Haukeland Hosp, Dept Med Biochem & Pharmacol, Bergen, Norway
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- Skadberg, Oyvind (författare)
- Stavanger Univ Hosp, Lab Med Biochem, Stavanger, Norway
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- Bonarjee, Vernon V. S. (författare)
- Stavanger Univ Hosp, Cardiol Dept, Stavanger, Norway
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- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Collinson, Paul (författare)
- St Georges Univ Hosp NHS Fdn Trust, Dept Clin Blood Sci, London, England;St Georges Univ Hosp NHS Fdn Trust, Dept Cardiol, London, England;St Georges Univ London, London, England
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- Omland, Torbjorn (författare)
- Akershus Univ Hosp, Div Med, Oslo, Norway;Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway
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- Vikenes, Kjell (författare)
- Haukeland Hosp, Dept Heart Dis, Bergen, Norway;Univ Bergen, Dept Clin Sci, Bergen, Norway
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- Aakre, Kristin M. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Med Biochem & Pharmacol, Bergen, Norway;Haukeland Hosp, Hormone Lab, Bergen, Norway
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(creator_code:org_t)
- 2019-07-01
- 2019
- Engelska.
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Ingår i: Scandinavian Cardiovascular Journal. - : TAYLOR & FRANCIS LTD. - 1401-7431 .- 1651-2006. ; 53:5, s. 280-285
- Relaterad länk:
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http://openaccess.sg...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives. The main aim of the Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain (WESTCOR-study) (Clinical Trials number NCT02620202) is to improve diagnostic pathways for patients presenting to the Emergency department (ED) with acute chest pain. Design. The WESTCOR-study is a two center, cross-sectional and prospective observational study recruiting unselected patients presenting to the ED with suspected non-ST elevation acute coronary syndrome (NSTE-ACS). Patient inclusion started September 2015 and we plan to include 2250 patients, finishing in 2019. The final diagnosis will be adjudicated by two independent cardiologists based on all available information including serial high sensitivity cardiac troponin measurements, coronary angiography, coronary CT angiography and echocardiography. The study includes one derivation cohort (N = 985) that will be used to develop rule out/rule in algorithms for NSTEMI and NSTE-ACS (if possible) using novel troponin assays, and to validate established NSTEMI algorithms, with and without clinical scoring systems. The study further includes one subcohort (n = 500) where all patients are examined with coronary CT angiography independent of biomarker status, aiming to assess the associations between biomarkers and the extent and severity of coronary atherosclerosis. Finally, an external validation cohort (N = 750) will be included at Stavanger University Hospital. Prospective studies will be based on the merged cohorts. Conclusion. The WESTCOR study will provide new diagnostic algorithms for early inclusion and exclusion of NSTE-ACS and insights in the associations between cardiovascular biomarkers, CT-angiographic findings and short and long-term clinical outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Chest pain
- acute coronary syndrome
- cardiovascular biomarkers
- rule in
- rule out algorithms
- troponin
- NSTEMI
- unstable angina pectoris
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Tjora, Hilde L.
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Steiro, Ole-Thom ...
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Langorgen, Jorun ...
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Bjorneklett, Run ...
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Nygard, Ottar K.
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Renstrom, Renate
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Skadberg, Oyvind
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Bonarjee, Vernon ...
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Lindahl, Bertil, ...
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Collinson, Paul
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Omland, Torbjorn
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Vikenes, Kjell
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Aakre, Kristin M ...
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