Search: WFRF:(Kilic A.) >
Systemic manifestat...
-
Retamozo, S.UNC, Consejo Nacl Invest Cient & Tecn CONICET, Inst Invest Ciencias Salud INICSA, Cordoba, Argentina;IUCBC, Cordoba, Argentina
(author)
Systemic manifestations of primary Sjogren's syndrome out of the ESSDAI classification : prevalence and clinical relevance in a large international, multi-ethnic cohort of patients
- Article/chapterEnglish2019
Publisher, publication year, extent ...
-
CLINICAL & EXPER RHEUMATOLOGY,2019
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-396444
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396444URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:141992299URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:142826741URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Objectives: To analyse the frequency and characterise the systemic presentation of primary Sjogren's syndrome (SS) out of the ESSDAI classification in a large international, multi-ethnic cohort of patients. Methods: The Big Data Sjogren Project Consortium is an international, multicentre registry based on world-wide data-sharing and cooperative merging of pre-existing clinical SS databases from leading centres in clinical research in SS from the five continents. A list of 26 organ-by-organ systemic features not currently included in the ESSDAI classification was defined according to previous studies; these features were retrospectively recorded. Results: Information about non-ESSDAI features was available in 6331 patients [5,917 female, mean age at diagnosis 52 years, mainly White (86.3%)]. A total of 1641 (26%) patients had at least one of the ESSDAI systemic features. Cardiovascular manifestations were the most frequent organ-specific group of non-ESSDAI features reported in our patients (17% of the total cohort), with Raynaud's phenomenon being reported in 15%. Patients with systemic disease due to non-ESSDAI features had a lower frequency of dry mouth (90.7% vs. 94.1%, p<0.001) and positive minor salivary gland biopsy (86.7% vs. 89%, p=0.033), a higher frequency of anti-Ro/SSA (74.7% vs. 68.7%, p<0.001), anti-La/SSB antibodies (44.5% vs. 40.4%, p=0.004), ANA (82.7% vs. 79.5%, p=0.006), low C3 levels (17.4% vs. 9.7%, p<0.001), low C4 levels (14.4% vs. 9.6%, p<0.001), and positive serum cryoglobulins (8.6% vs. 5.5%, p=0.001). Systemic activity measured by the ESSDAI, clinESSDAI and DAS was higher in patients with systemic disease out of the ESSDAI in comparison with those without these features (p<0.001 for all comparisons). Conclusions: More than a quarter of patients with primary SS may have systemic manifestations not currently included in the ESSDAI classification, with a wide variety of cardiovascular, digestive, pulmonary, neurological, ocular, ENT (ear, nose, and throat), cutaneous and urological features that increase the scope of the systemic phenotype of the disease. However, the individual frequency of each of these non-ESSDAI features was very low, except for Raynaud's phenomenon.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Acar-Denizli, N.Mimar Sinant Fine Arts Univ, Fac Sci & Letters, Dept Stat, Istanbul, Turkey
(author)
-
Rasmussen, A.Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Programme, 825 NE 13th St, Oklahoma City, OK 73104 USA
(author)
-
Horvath, I. F.Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary
(author)
-
Baldini, C.Univ Pisa, Rheumatol Unit, Pisa, Italy
(author)
-
Priori, R.Sapienza Univ Rome, Rheumatol Clin, Dept Internal Med & Med Specialties, Rome, Italy
(author)
-
Sandhya, P.Christian Med Coll & Hosp, Dept Clin Immunol & Rheumatol, Vellore, Tamil Nadu, India
(author)
-
Hernandez-Molina, G.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico
(author)
-
Armagan, B.Hacettepe Univ, Fac Med, Dept Internal Med, Ankara, Turkey
(author)
-
Praprotnik, S.Univ Med Ctr, Dept Rheumatol, Ljubljana, Slovenia
(author)
-
Kvarnstrom, M.Karolinska Institutet
(author)
-
Gerli, R.Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy
(author)
-
Sebastian, A.Wroclaw Med Univ, Dept Rheumatol & Internal Med, Wroclaw, Poland
(author)
-
Solans, R.Hosp Valle De Hebron, Dept Internal Med, Barcelona, Spain
(author)
-
Rischmueller, M.Queen Elizabeth Hosp, Dept Rheumatol, Adelaide, SA, Australia;Univ Adelaide, Adelaide, SA, Australia
(author)
-
Pasoto, S. G.Univ Sao Paulo, Fac Med, HCFMUSP, Hosp Clin,Rheumatol Div, Sao Paulo, Brazil
(author)
-
Valim, V.Univ Fed Espirito Santo, Dept Med, Vitoria, ES, Brazil
(author)
-
Nordmark, GunnelUppsala universitet,Reumatologi(Swepub:uu)gunnnord
(author)
-
Kruize, A. A.Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands
(author)
-
Nakamura, H.Nagasaki Univ, Grad Sch Biomed Sci, Div Adv Prevent Med Sci, Dept Immunol & Rheumatol, Nagasaka, Yamanashi, Japan
(author)
-
Hofauer, B.Univ Freiburg, Otorhinolaryngol Head & Neck Surg, Freiburg, Germany
(author)
-
Giacomelli, R.Univ Aquila, Sch Med, Clin Unit Rheumatol, Laquila, Italy
(author)
-
Fernandes Moca Trevisani, V.Univ Fed Sao Paulo, Sao Paulo, Brazil
(author)
-
Devauchelle-Pensec, V.Brest Univ Hosp, Rheumatol Dept, Paris, France
(author)
-
Atzeni, F.Univ Messina, Inst Milan, IRCCS Galeazzi Orthopaed, Messina, Italy;Univ Messina, Rheumatol Unit, Messina, Italy
(author)
-
Gheita, T. A.Cairo Univ, Kasr Al Amny Sch Med, Rheumatol Dept, Cairo, Egypt
(author)
-
Consani-Fernandez, S.Hosp Maciel, Internal Med, Montevideo, Uruguay;Univ Republ UdelaR, Montevideo, Uruguay
(author)
-
Szanto, A.Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary
(author)
-
Sivils, K.Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Programme, 825 NE 13th St, Oklahoma City, OK 73104 USA
(author)
-
Gattamelata, A.Sapienza Univ Rome, Rheumatol Clin, Dept Internal Med & Med Specialties, Rome, Italy
(author)
-
Danda, D.Christian Med Coll & Hosp, Dept Clin Immunol & Rheumatol, Vellore, Tamil Nadu, India
(author)
-
Kilic, L.Hacettepe Univ, Fac Med, Dept Internal Med, Ankara, Turkey
(author)
-
Bartoloni, E.
(author)
-
Bombardieri, S.
(author)
-
Sanchez-Guerrero, J.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico
(author)
-
Wahren-Herlenius, M.Karolinska Institutet
(author)
-
Mariette, X.Univ Paris Sud, Ctr Immunol Viral Infect & Autoimmune Dis, Hop Univ Paris Sud, AP HP,UMR1184,INSERM, Paris, France
(author)
-
Ramos-Casals, M.Univ Barcelona, Sjogrens Syndrome Res Grp AGAUR, Lab Autoimmune Dis Josep Font,Hosp Clin, IDIBAPS CELLEX,Dept Autoimmune Dis ICMiD, Barcelona, Spain
(author)
-
Brito-Zeron, P.Univ Barcelona, Sjogrens Syndrome Res Grp AGAUR, Lab Autoimmune Dis Josep Font,Hosp Clin, IDIBAPS CELLEX,Dept Autoimmune Dis ICMiD, Barcelona, Spain;Hosp CIMA Sanitas, Dept Med, Autoinmmne Dis Unit, Barcelona, Spain
(author)
-
Nakamura, T
(author)
-
UNC, Consejo Nacl Invest Cient & Tecn CONICET, Inst Invest Ciencias Salud INICSA, Cordoba, Argentina;IUCBC, Cordoba, ArgentinaMimar Sinant Fine Arts Univ, Fac Sci & Letters, Dept Stat, Istanbul, Turkey
(creator_code:org_t)
Related titles
-
In:Clinical and Experimental Rheumatology: CLINICAL & EXPER RHEUMATOLOGY710392-856X1593-098X
-
In:ARTHRITIS & RHEUMATOLOGY: CLINICAL & EXPER RHEUMATOLOGY712326-5191
Internet link
Find in a library
To the university's database
- By the author/editor
-
Retamozo, S.
-
Acar-Denizli, N.
-
Rasmussen, A.
-
Horvath, I. F.
-
Baldini, C.
-
Priori, R.
-
show more...
-
Sandhya, P.
-
Hernandez-Molina ...
-
Armagan, B.
-
Praprotnik, S.
-
Kvarnstrom, M.
-
Gerli, R.
-
Sebastian, A.
-
Solans, R.
-
Rischmueller, M.
-
Pasoto, S. G.
-
Valim, V.
-
Nordmark, Gunnel
-
Kruize, A. A.
-
Nakamura, H.
-
Hofauer, B.
-
Giacomelli, R.
-
Fernandes Moca T ...
-
Devauchelle-Pens ...
-
Atzeni, F.
-
Gheita, T. A.
-
Consani-Fernande ...
-
Szanto, A.
-
Sivils, K.
-
Gattamelata, A.
-
Danda, D.
-
Kilic, L.
-
Bartoloni, E.
-
Bombardieri, S.
-
Sanchez-Guerrero ...
-
Wahren-Herlenius ...
-
Mariette, X.
-
Ramos-Casals, M.
-
Brito-Zeron, P.
-
Nakamura, T
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Clinical and Exp ...
-
ARTHRITIS & RHEU ...
- By the university
-
Uppsala University
-
Karolinska Institutet