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A clonal expression...
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Biswas, DhruvaUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;UCL, Inst Canc, Bill Lyons Informat Ctr, Paul OGorman Bldg, London, England;Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,Francis Crick Institute,University College London
(author)
A clonal expression biomarker associates with lung cancer mortality
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-10-07
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Springer Science and Business Media LLC,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-396656
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396656URI
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https://doi.org/10.1038/s41591-019-0595-zDOI
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https://lup.lub.lu.se/record/425ddb85-2351-4c76-859b-a2fc61ede68aURI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141988555URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage(1). Transcriptomic intratumor heterogeneity (RNA-ITH) has been shown to confound existing expression-based biomarkers across multiple cancer types(2-6). Here, we analyze multi-region whole-exome and RNA sequencing data for 156 tumor regions from 48 patients enrolled in the TRACERx study to explore and control for RNA-ITH in non-small cell lung cancer. We find that chromosomal instability is a major driver of RNA-ITH, and existing prognostic gene expression signatures are vulnerable to tumor sampling bias. To address this, we identify genes expressed homogeneously within individual tumors that encode expression modules of cancer cell proliferation and are often driven by DNA copy-number gains selected early in tumor evolution. Clonal transcriptomic biomarkers overcome tumor sampling bias, associate with survival independent of clinicopathological risk factors, and may provide a general strategy to refine biomarker design across cancer types.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Birkbak, Nicolai J.UCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England;Aarhus Univ, Dept Mol Med, Aarhus, Denmark;Aarhus Univ, Bioinformat Res Ctr, Aarhus, Denmark,Francis Crick Institute,Aarhus University,University College London
(author)
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Rosenthal, RachelUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;UCL, Inst Canc, Bill Lyons Informat Ctr, Paul OGorman Bldg, London, England;Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,University College London,Francis Crick Institute
(author)
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Hiley, Crispin T.UCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,University College London,Francis Crick Institute
(author)
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Lim, Emilia L.UCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,University College London,Francis Crick Institute
(author)
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Papp, KrisztianEotvos Lorand Univ, Dept Phys Complex Syst, Budapest, Hungary,Eötvös Loránd University
(author)
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Boeing, StefanFrancis Crick Inst, Bioinformat & Biostat, London, England,Francis Crick Institute
(author)
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Krzystanek, MarcinDanish Canc Soc, Res Ctr, Copenhagen, Denmark,Danish Cancer Society
(author)
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Djureinovic, DijanaUppsala University,Uppsala universitet,Klinisk och experimentell patologi(Swepub:uu)dijdj435
(author)
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La Fleur, LinneaUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Johan Botling(Swepub:uu)linla513
(author)
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Greco, MariaFrancis Crick Inst, Genom Equipment Pk, London, England,Francis Crick Institute
(author)
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Döme, BalázsSemmelweis Univ, Natl Koranyi Inst Pulmonol, Dept Tumor Biol, Budapest, Hungary;Med Univ Vienna, Ctr Comprehens Canc, Div Thorac Surg, Vienna, Austria;Semmelweis Univ, Natl Inst Oncol, Dept Thorac Surg, Budapest, Hungary,Semmelweis University,Medical University of Vienna(Swepub:lu)ba1464do
(author)
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Fillinger, JanosSemmelweis Univ, Natl Koranyi Inst Pulmonol, Dept Pathol, Budapest, Hungary;Natl Inst Oncol, Dept Pathol, Budapest, Hungary,National Institute of Oncology, Budapest,Semmelweis University
(author)
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Brunnström, HansLund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Region Skåne,Lund Univ, Lab Med Reg Skane, Dept Clin Sci Lund, Pathol, Lund, Sweden(Swepub:lu)med-hsb
(author)
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Wu, YinUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England,University College London
(author)
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Moore, David A.UCL Canc Inst, Dept Pathol, London, England,UCL Cancer Institute
(author)
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Skrzypski, MarcinUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;Med Univ Gdansk, Dept Oncol & Radiotherapy, Gdansk, Poland,Medical University of Gdansk,University College London
(author)
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Abbosh, ChristopherUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England,University College London
(author)
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Litchfield, KevinFrancis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,Francis Crick Institute(Swepub:lu)med-kl3
(author)
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Al Bakir, MaiseFrancis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,Francis Crick Institute
(author)
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Watkins, Thomas B. K.Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,Francis Crick Institute
(author)
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Veeriah, SelvarajuUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England,University College London
(author)
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Wilson, Gareth A.UCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,University College London,Francis Crick Institute
(author)
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Jamal-Hanjani, MariamUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England,University College London
(author)
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Moldvay, JuditSemmelweis Univ, Natl Koranyi Inst Pulmonol, Dept Tumor Biol, Budapest, Hungary;Semmelweis Univ, Dept Pathol 2, SE NAP Brain Metastasis Res Grp, Budapest, Hungary,Semmelweis University
(author)
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Botling, JohanUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Johan Botling(Swepub:uu)johanbot
(author)
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Chinnaiyan, Arul M.Univ Michigan, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA;Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA;Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA;Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA;Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA,University of Michigan
(author)
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Micke, PatrickUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke(Swepub:uu)patmi676
(author)
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Hackshaw, AllanUCL, Canc Res UK, London, England;UCL, Univ Coll London Canc Trials Ctr, London, England,University College London
(author)
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Bartek, JiriKarolinska Institutet,Karolinska Institute,Danish Cancer Society,Danish Canc Soc, Res Ctr, Copenhagen, Denmark;Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden
(author)
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Csabai, IstvanEotvos Lorand Univ, Dept Phys Complex Syst, Budapest, Hungary,Eötvös Loránd University
(author)
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Szallasi, ZoltanDanish Canc Soc, Res Ctr, Copenhagen, Denmark;Semmelweis Univ, Dept Pathol 2, SE NAP Brain Metastasis Res Grp, Budapest, Hungary;Harvard Med Sch, Boston Childrens Hosp, Computat Hlth Informat Program, Boston, MA 02115 USA,Harvard University,Semmelweis University,Boston Children's Hospital,Danish Cancer Society
(author)
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Herrero, JavierUCL, Inst Canc, Bill Lyons Informat Ctr, Paul OGorman Bldg, London, England,University College London
(author)
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McGranahan, NicholasUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;UCL, Univ Coll London Canc Inst, Canc Genome Evolut Res Grp, London, England,University College London
(author)
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Swanton, CharlesUCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England,University College London,Francis Crick Institute
(author)
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UCL, Inst Canc, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg, London, England;UCL, Inst Canc, Bill Lyons Informat Ctr, Paul OGorman Bldg, London, England;Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, EnglandFrancis Crick Institute
(creator_code:org_t)
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In:Nature Medicine: Springer Science and Business Media LLC25:10, s. 1540-15481078-89561546-170X
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Biswas, Dhruva
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Birkbak, Nicolai ...
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Rosenthal, Rache ...
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Hiley, Crispin T ...
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Lim, Emilia L.
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Papp, Krisztian
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Boeing, Stefan
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Krzystanek, Marc ...
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Djureinovic, Dij ...
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La Fleur, Linnea
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Greco, Maria
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Döme, Balázs
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Fillinger, Janos
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Brunnström, Hans
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Wu, Yin
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Moore, David A.
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Skrzypski, Marci ...
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Abbosh, Christop ...
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Litchfield, Kevi ...
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Al Bakir, Maise
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Watkins, Thomas ...
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Veeriah, Selvara ...
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Wilson, Gareth A ...
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Jamal-Hanjani, M ...
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Moldvay, Judit
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Botling, Johan
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Chinnaiyan, Arul ...
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Micke, Patrick
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Hackshaw, Allan
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Bartek, Jiri
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Csabai, Istvan
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Szallasi, Zoltan
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Herrero, Javier
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McGranahan, Nich ...
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Swanton, Charles
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