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Lowered anti-beta1 ...
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Ernst, DianaMed Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
(författare)
Lowered anti-beta1 adrenergic receptor antibody concentrations may have prognostic significance in acute coronary syndrome
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-10-10
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NATURE PUBLISHING GROUP,2019
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-396717
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396717URI
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https://doi.org/10.1038/s41598-019-51125-9DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Although several risk factors exist for acute coronary syndrome (ACS) no biomarkers for survival or risk of re-infarction have been validated. Previously, reduced serum concentrations of anti-beta(1)AR Ab have been implicated in poorer ACS outcomes. This study further evaluates the prognostic implications of anti-beta(1)AR-Ab levels at the time of ACS onset. Serum anti-beta(1)AR Ab concentrations were measured in randomly selected patients from within the PLATO cohort. Stratification was performed according to ACS event: ST-elevation myocardial infarct (STEMI) vs. non-ST elevation myocardial infarct (NSTEMI). Antibody concentrations at ACS presentation were compared to 12-month all-cause and cardiovascular mortality, as well as 12-month re-infarction. Sub-analysis, stratifying for age and the correlation between antibody concentration and conventional cardiac risk-factors was subsequently performed. Serum anti-beta(1)AR Ab concentrations were measured in 400/799 (50%) STEMI patients and 399 NSTEMI patients. Increasing anti-beta(1)AR Ab concentrations were associated with STEMI (p = 0.001). Across all ACS patients, no associations between anti-beta(1)AR Ab concentration and either all-cause cardiovascular death or myocardial re-infarction (p = 0.14) were evident. However among STEMI patients <60 years with anti-beta(1)AR Ab concentration median (14/198 (7.1%) vs. 2/190 (1.1%)); p = 0.01). Similarly, the same sub-group demonstrated greater risk of cardiovascular death in year 1, including re-infarction and stroke (22/198 (11.1%) vs. 10/190 (5.3%); p = 0.017). ACS Patients <= 60 years, exhibiting lower concentrations of beta(1)AR Ab carry a greater risk for early re-infarction and cardiovascular death. Large, prospective studies quantitatively assessing the prognostic relevance of Anti-beta(1)AR Ab levels should be considered.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Westerbergh, JohanUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)johwe257
(författare)
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Sogkas, GeorgiosMed Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
(författare)
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Jablonka, AlexandraMed Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
(författare)
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Ahrenstorf, GerritMed Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
(författare)
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Schmidt, Reinhold ErnstMed Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
(författare)
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Heidecke, HaraldCellTrend GmbH, Luckenwalde, Germany
(författare)
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Wallentin, Lars,1943-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall
(författare)
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Riemekasten, GabrielaUniv Schleswig Holstein, Dept Rheumatol, Lubeck, Germany
(författare)
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Witte, TorstenMed Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
(författare)
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Med Sch Hannover, Dept Immunol & Rheumatol, Hannover, GermanyUppsala kliniska forskningscentrum (UCR)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific Reports: NATURE PUBLISHING GROUP92045-2322
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Ernst, Diana
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Westerbergh, Joh ...
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Sogkas, Georgios
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Jablonka, Alexan ...
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Ahrenstorf, Gerr ...
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Schmidt, Reinhol ...
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Heidecke, Harald
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Wallentin, Lars, ...
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Riemekasten, Gab ...
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Witte, Torsten
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Uppsala universitet