Sökning: WFRF:(Herrmann Sandra)
> (2015-2019) >
Impact of a single ...
Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal
-
- Harding-Esch, Emma M. (författare)
- London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
-
- Holland, Martin J. (författare)
- London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England;MRC Labs, POB 273, Fajara, Banjul, Gambia
-
- Schemann, Jean-Francois (författare)
- IRD, Dakar, Senegal
-
visa fler...
-
- Sillah, Ansumana (författare)
- Minist Hlth & Social Welf, Natl Eye Hlth Programme, Kanifing, Gambia
-
- Sarr, Boubacar (författare)
- Minist Sante, Programme Natl Lutte Cecite, BP 3817, Dakar, Senegal
-
- Christerson, Linus (författare)
- Uppsala universitet,Klinisk mikrobiologi
-
- Pickering, Harry (författare)
- London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
-
- Molina-Gonzalez, Sandra (författare)
- London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
-
- Sarr, Isatou (författare)
- MRC Labs, POB 273, Fajara, Banjul, Gambia
-
- Andreasen, Aura A. (författare)
- London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
-
- Jeffries, David (författare)
- MRC Labs, POB 273, Fajara, Banjul, Gambia
-
- Grundy, Chris (författare)
- London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
-
- Mabey, David C. W. (författare)
- London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
-
- Herrmann, Björn, 1955- (författare)
- Uppsala universitet,Klinisk mikrobiologi
-
- Bailey, Robin L. (författare)
- London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
-
visa färre...
-
(creator_code:org_t)
- 2019-10-22
- 2019
- Engelska.
-
Ingår i: Parasites & Vectors. - : BMC. - 1756-3305. ; 12
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://parasitesand...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Mass drug administration (MDA) with azithromycin is a cornerstone of the trachoma elimination strategy. Although the global prevalence of active trachoma has declined considerably, prevalence persists or even increases in some communities and districts. To increase understanding of MDA impact, we investigated the prevalence of active trachoma and ocular C. trachomatis prevalence, organism load, and circulating strains at baseline and one-year post-MDA in The Gambia and Senegal.Methods: Pre- and one-year post-MDA, children aged 0-9 years were examined for clinical signs of trachoma in six Gambian and 12 Senegalese villages. Ocular swabs from each child's right conjunctiva were tested for evidence of ocular C. trachomatis infection and organism load (ompA copy number), and ompA and multi-locus sequence typing (MLST) was performed.Results: A total of 1171 children were examined at baseline and follow-up in The Gambia. Active trachoma prevalence decreased from 23.9% to 17.7%, whereas ocular C. trachomatis prevalence increased from 3.0% to 3.8%. In Senegal, 1613 and 1771 children were examined at baseline and follow-up, respectively. Active trachoma prevalence decreased from 14.9% to 8.0%, whereas ocular C. trachomatis prevalence increased from 1.8% to 3.6%. Higher organism load was associated with having active trachoma and severe inflammation. Sequence typing demonstrated that all Senegalese samples were genovar A, whereas Gambian samples were a mix of genovars A and B. MLST provided evidence of clustering at village and household levels and demonstrated differences of strain variant frequencies in Senegal, indicative of an "outbreak". MLST, including partial ompA typing, provided greater discriminatory power than complete ompA typing.Conclusions: We found that one round of MDA led to an overall decline in active trachoma prevalence but no impact on ocular C. trachomatis infection, with heterogeneity observed between villages studied. This could not be explained by MDA coverage or number of different circulating strains pre- and post-MDA. The poor correlation between active trachoma and infection prevalence supports the need for further work on alternative indicators to clinical signs for diagnosing ocular C. trachomatis infection. MLST typing has potential molecular epidemiology utility, including better understanding of transmission dynamics, although relationship to whole-genome sequence variability requires further exploration.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Active trachoma
- Chlamydia trachomatis
- Ocular
- Mass drug administration
- Azithromycin
- Prevalence
- Whole-genome sequence
- Organism load
- ompA
- Multi locus sequence typing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Harding-Esch, Em ...
-
Holland, Martin ...
-
Schemann, Jean-F ...
-
Sillah, Ansumana
-
Sarr, Boubacar
-
Christerson, Lin ...
-
visa fler...
-
Pickering, Harry
-
Molina-Gonzalez, ...
-
Sarr, Isatou
-
Andreasen, Aura ...
-
Jeffries, David
-
Grundy, Chris
-
Mabey, David C. ...
-
Herrmann, Björn, ...
-
Bailey, Robin L.
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Mikrobiologi
- Artiklar i publikationen
-
Parasites & Vect ...
- Av lärosätet
-
Uppsala universitet