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- Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Ortopedi (författare)
Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer's Disease? A Systematic Review and Meta-Analysis.
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
- Stockholm :Karolinska Institutet, Institute of Environmental Medicine,2018
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-397251
- ISSN:1387-2877
- 10616/46419hdl
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397251URI
- https://doi.org/10.3233/JAD-180288DOI
- http://hdl.handle.net/10616/46419URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:138564944URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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Anmärkningar
- BACKGROUND: Epidemiological evidence has associated Alzheimer's disease (AD) with vascular risk factors (VRFs), but whether treatment of VRFs reduces the incidence of dementia and AD is uncertain.OBJECTIVE: To conduct a systematic review and meta-analysis to summarize available data on the impact of treatment of VRFs on dementia and AD incidence.METHODS: Pertinent studies published until 1 January 2018 were identified from PubMed. Both randomized controlled trials (RCT) and prospective studies that investigated the impact of treatment of VRFs on dementia or AD incidence were included.RESULTS: Eight RCTs and 52 prospective studies were identified. Antihypertensive treatment was associated with a non-significant reduced risk of dementia in RCTs (n = 5; relative risk [RR], 0.84; 95% confidence interval [CI], 0.69-1.02) and prospective studies (n = 3; RR, 0.77; 95% CI, 0.58-1.01) and with reduced AD risk in prospective studies (n = 5; RR = 0.78; 95% CI, 0.66-0.91). In prospective studies, treatment of hyperlipidemia with statins, but not nonstatin lipid-lowering agents, was associated with reduced risk of dementia (n = 17; RR, 0.77; 95% CI, 0.63-0.95) and AD (n = 13; RR, 0.86; 95% CI, 0.80-0.92). The single RCT on statins and dementia incidence showed no association. Data from one RCT and six prospective studies did not support a beneficial impact of antidiabetic drugs or insulin therapy on dementia risk.CONCLUSION: Current evidence indicates that antihypertensives and statins might reduce the incidence of dementia and AD. Further trials to determine the effect of VRF on AD are needed.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
- Alzheimer’s disease
- dementia
- meta-analysis
- prevention
- prospective studies
- randomized controlled trials
- risk factors
- systematic review
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Markus, Hugh S (författare)
- Uppsala universitetOrtopedi (creator_code:org_t)
- Karolinska Institutet
- Karolinska Institutet
Sammanhörande titlar
- Ingår i:Journal of Alzheimer's DiseaseStockholm : Karolinska Institutet, Institute of Environmental Medicine64:2, s. 657-6681387-28771875-8908
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