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The Parkinson's Dis...
The Parkinson's Disease Genome-Wide Association Study Locus Browser
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- Grenn, Francis P. (författare)
- National Institutes of Health, United States
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- Kim, Jonggeol J. (författare)
- National Institutes of Health, United States
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- Makarious, Mary B. (författare)
- National Institutes of Health, United States
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visa fler...
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- Iwaki, Hirotaka (författare)
- Data Tecnica International,National Institutes of Health, United States
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- Illarionova, Anastasia (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Brolin, Kajsa (författare)
- Lund University,Lunds universitet,Translationell Neurogenetik,Forskargrupper vid Lunds universitet,Translational Neurogenetics,Lund University Research Groups
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- Kluss, Jillian H. (författare)
- National Institutes of Health, United States
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- Schumacher-Schuh, Artur F. (författare)
- Hospital de Clinicas de Porto Alegre
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- Leonard, Hampton (författare)
- National Institutes of Health, United States,Data Tecnica International
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- Faghri, Faraz (författare)
- National Institutes of Health, United States,Data Tecnica International
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- Billingsley, Kimberley (författare)
- National Institutes of Health, United States
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- Krohn, Lynne (författare)
- McGill University
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- Hall, Ashley (författare)
- University of Liverpool
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- Diez-Fairen, Monica (författare)
- Mutua De Terrassa Hospital
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- Periñán, Maria Teresa (författare)
- University Hospital Virgen del Rocío
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- Sandor, Cynthia (författare)
- Cardiff University
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- Webber, Caleb (författare)
- Cardiff University
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- Fiske, Brian K. (författare)
- The Michael J. Fox Foundation for Parkinson’s Research
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- Gibbs, J. Raphael (författare)
- National Institutes of Health, United States
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- Nalls, Mike A. (författare)
- National Institutes of Health, United States,Data Tecnica International
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- Singleton, Andrew B. (författare)
- National Institutes of Health, United States
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- Bandres-Ciga, Sara (författare)
- National Institutes of Health, United States
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- Reed, Xylena (författare)
- National Institutes of Health, United States
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- Blauwendraat, Cornelis (författare)
- National Institutes of Health, United States
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(creator_code:org_t)
- 2020-08-31
- 2020
- Engelska.
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Ingår i: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257.
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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https://movementdiso...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Parkinson's disease (PD) is a neurodegenerative disease with an often complex component identifiable by genome-wide association studies. The most recent large-scale PD genome-wide association studies have identified more than 90 independent risk variants for PD risk and progression across more than 80 genomic regions. One major challenge in current genomics is the identification of the causal gene(s) and variant(s) at each genome-wide association study locus. The objective of the current study was to create a tool that would display data for relevant PD risk loci and provide guidance with the prioritization of causal genes and potential mechanisms at each locus. Methods: We included all significant genome-wide signals from multiple recent PD genome-wide association studies including themost recent PD risk genome-wide association study, age-at-onset genome-wide association study, progression genome-wide association study, and Asian population PD risk genome-wide association study. We gathered data for all genes 1 Mb up and downstream of each variant to allow users to assess which gene(s) are most associated with the variant of interest based on a set of self-ranked criteria. Multiple databases were queried for each gene to collect additional causal data. Results: We created a PD genome-wide association study browser tool (https://pdgenetics.shinyapps.io/GWASBrowser/) to assist the PD research community with the prioritization of genes for follow-up functional studies to identify potential therapeutic targets. Conclusions: Our PD genome-wide association study browser tool provides users with a useful method of identifying potential causal genes at all known PD risk loci from large-scale PD genome-wide association studies. We plan to update this tool with new relevant data as sample sizes increase and new PD risk loci are discovered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- GWAS
- Parkinson's disease
- prioritization
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Grenn, Francis P ...
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Kim, Jonggeol J.
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Makarious, Mary ...
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Iwaki, Hirotaka
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Illarionova, Ana ...
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Brolin, Kajsa
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visa fler...
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Kluss, Jillian H ...
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Schumacher-Schuh ...
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Leonard, Hampton
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Faghri, Faraz
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Billingsley, Kim ...
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Krohn, Lynne
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Hall, Ashley
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Diez-Fairen, Mon ...
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Periñán, Maria T ...
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Sandor, Cynthia
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Webber, Caleb
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Fiske, Brian K.
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Gibbs, J. Raphae ...
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Nalls, Mike A.
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Singleton, Andre ...
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Bandres-Ciga, Sa ...
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Reed, Xylena
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Blauwendraat, Co ...
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