Combined impact of healthy lifestyle factors on risk of atrial fibrillation: Prospective study in men and women.

Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Ortopedi (författare)

Combined impact of healthy lifestyle factors on risk of atrial fibrillation : Prospective study in men and women.

BACKGROUND: The combined impact of multiple lifestyle factors on risk of atrial fibrillation (AF) remains unclear. We investigated the joint association of four modifiable lifestyle factors on incidence of AF in a prospective study of men and women.METHODS: The study cohort comprised 39 300 men in the Cohort of Swedish Men and 33 090 women in the Swedish Mammography Cohort who were 45-83 years of age and free from atrial fibrillation at baseline. Healthy lifestyle was defined as body mass index <25 kg/m(2), regular exercise for ≥ 20 min/day, no or light-to-moderate alcohol consumption (≤ 2 drinks/day for men and ≤ 1 drink/day for women), and not smoking. Incident AF cases were identified through linkage with the Swedish National Inpatient Register.RESULTS: During a mean follow-up of 10.9 years, AF occurred in 4028 men and 2539 women. Compared with men and women with no healthy lifestyle factors, the multivariable relative risks (95% confidence interval) of AF were 0.83 (0.65-1.07) for one, 0.74 (0.58-0.94) for two, 0.62 (0.49-0.79) for three, and 0.50 (0.39-0.64) for four healthy lifestyle factors (P for trend <0.0001). The inverse association was similar in men and women.CONCLUSIONS: Four healthy lifestyle factors combined were associated with a halving of the risk of AF.

Drca, NikolaKarolinska Institutet (författare)
Jensen-Urstad, MatsKarolinska Institutet (författare)
Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi(Swepub:uu)alwol516 (författare)
Uppsala universitetOrtopedi (creator_code:org_t)

Ingår i:International Journal of Cardiology: Elsevier203, s. 46-90167-52731874-1754

Av författaren/redakt...: Larsson, Susanna ...; Drca, Nikola; Jensen-Urstad, M ...; Wolk, Alicja

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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